대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제50권2호
  • /
  • Pages.143-151
  • /
  • 2024
  • /
  • 1226-2587(pISSN)
  • /
  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
권호 표지
DOI QR코드

DOI QR Code

제형별 오존 free 플라즈마 안정도 검토

Stability Review of Formulations Produced with Ozone Free Plasma

  • 천유연 (아주대학교 생명과학과) ;
  • 조하현 (아주대학교 생명과학과) ;
  • 백문기 (아주대학교 화장품학과) ;
  • 박선주 (아주대학교 생명과학과) ;
  • ;
  • 빈범호 (아주대학교 생명과학과)
  • You-Yeon Chun (Department of Biological Science, Ajou University) ;
  • Ha Hyeon Jo (Department of Biological Science, Ajou University) ;
  • Moonki Baek (Department of Cosmetology, Ajou University) ;
  • Sun Ju Park (Department of Biological Science, Ajou University) ;
  • Sofia Brito (Department of New Materials, Sungkyunkwan University) ;
  • Bum-Ho Bin (Department of Biological Science, Ajou University)
  • 투고 : 2024.05.14
  • 심사 : 2024.06.18
  • 발행 : 2024.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

오존은 무색의 독성 가스로, 질소 산화물과 탄화수소가 태양 광선에 의해 광화학 산화 반응이 일어나면서 생성된다. 낮은 농도여도 호흡기 기관에 영향을 주고, 기침 또는 인체에 해롭다. 화장품 원료 중 질소 플라즈마에서 오존이 생성되는 것을 확인하였고, 1 day 후부터 오존의 농도가 낮아짐을 알 수 있었다. 반면 아르곤 가스로 발생된 오존 free 플라즈마는 오존이 검출되지 않았다. 따라서 오존 free 플라즈마를 활용하여 오존 free 화장품의 제조를 목표로 하였다. 효율적인 플라즈마 처리를 위해 non-sinking 법을 활용하여 층분리 미스트, 토너와 앰플에 주입하고, 안정도를 관찰하였다. 층분리 미스트에서 플라즈마의 주입 성공량이 두 제형보다 많았으나, 토너와 앰플에 비해 급격히 감소함을 확인할 수 있었다. 사용된 오존 free 플라즈마는 저온(4 ℃), RT (25 ℃), 고온(37 ℃, 50 ℃) 조건에서 층분리 미스트, 토너와 앰플의 안정도에 영향이 미치지 않는 것을 확인하였다. 따라서, 본 연구는 오존 free 플라즈마의 제형별 화장품 가능성과 안정성의 중요성을 시사하고 있다.

Ozone is a colorless, toxic gas that is produced when nitrogen oxides and hydrocarbons undergo a photochemical oxidation reaction in the sun's rays. Even at low concentrations, it affects the respiratory system, causing coughing and other harmful effects. It was confirmed that ozone was generated from nitrogen plasma among cosmetic raw materials, and it was found that the concentration of ozone decreased after 1 day. On the other hand, ozone was not detected in ozone-free plasma generated with argon gas. Therefore, we aimed to produce ozone-free cosmetics by utilizing ozone-free plasma. For efficient plasma processing, the non-sinking method was utilized to inject the plasma into layer separation mists, toners, and ampoules, and the stability was observed. It was found that the successful injection of plasma in the layer separation mist was higher than the other two formulations, but decreased sharply compared to the toner and ampoule. It was found that the ozone-free plasma used did not affect the stability of the layer separation mist, toner, and ampoule under low temperature (4 ℃), room temperature (25 ℃), and high temperature (37 ℃, 50 ℃) conditions. Therefore, this study suggests the importance of ozone-free plasma for cosmetic potential and stability of each formulation.

키워드

참고문헌

  1. D. Park, Trends in low temperature plasma applications, KIC News, 25(1), 3 (2022). 
  2. J. H. Park, S. N. Yun, and Y. B. Ham, R&D trends in plasma technologies, J. Dirve Control, 5(3), 23 (2008). 
  3. K. Y. Kim, J. Yi, M. K. Nam., E. H. Choi, and H. Rhim, Effects of DBD-bio-plasma on the HSP70 of fibroblasts: A new approach on change of molecular level by heat shock in the cell, KSBB Journal, 30(1), 21 (2015). 
  4. S. R. Park, J. W. Hong, H. J. Lee, and G. C. Kim, Plasma medicine: How can nonthermal atmospheric plasma be applied to medicine, J. Life Sci., 23(6), 838 (2013).
  5. C. Bergemann, C. Hoppe, M. Karmazyna, M. Hontsch, M. Eggert, T. Gerling, and B. Nebe, Plasma Science and Technology-Progress in Physical States and Chemical Reactions, ed. Tetus Mieno, 156, Intech, London (2016). 
  6. M. Park, Master's Thesis dissertation, KAIST., Seoul, Korea (2007). 
  7. S. Iseni, S. Zhang, A. F. H. Van Gessel, S. Hofmann, B. T. J. Van Ham, S. Reuter, and P. J. Bruggeman, Nitric oxide density distributions in the effluent of an RF argon APPJ: effect of gas flow rate and substrate, New J. Phys., 16(12), 123011 (2014). 
  8. S. Iordanova and I. Koleva, Optical emission spectroscopy diagnostics of inductively-driven plasmas in argon gas at low pressures, Spectrochimica Acta Part B: Atomic Spectroscopy, 62(4), 344 (2007). 
  9. A. Chatterjee and J. D. Catravas, Endothelial nitric oxide (NO) and its pathophysiologic regulation, Vascular pharmacology, 49(4-6), 134 (2008). 
  10. M. Lippmann, Health effects of ozone a critical review. JAPCA, 39(5), 672 (1989). 
  11. V. Bocci, E. Borrelli, V. Travagli, and I. Zanardi, The ozone paradox: ozone is a strong oxidant as well as a medical drug, Med. Res. Rev., 29(4), 646 (2009). 
  12. J. Y. Chung and H. Kim, Effect of ozone on daily mortality focused on nonlinearity and interaction with temperature, J. Health Info Stat., 26(1), 3 (2001). 
  13. S. M. Lee, S. Y. Jung, B. Sofia, H. Heo, B. Cha, Lei. L, S. H. Lee, M. G. Lee, B. H. Bin, and B. M. Kwak, Evaluation of the potenial of nitrogen plasma to cosmetics, J. Soc. Cosmet. Sci. Korea, 48(3), 189 (2022). 
  14. Y. S. Lee, Role of nitric oxide in the TRPV1-mediated melanogenesis, Yakhak Hoeji, 64(5), 387 (2020). 
  15. H. Moshage, B. Kok, J. R. Huizenga, and P. L. Jansen, Nitrite and nitrate determinations in plasma: a critical evaluation, Clin. Chem., 41(6), 892 (1995). 
  16. B. J. Lee, Generation of low temperature plasma and its application, Trans. Korean. Inst. Elec t. Eng., 51(9), 413 (2002). 
  17. S. Y. Cho, Effect of surface ozone on vegetation in korea preliminary study on early foliage of robinia pseudoacacia, J. Korean Soc. Atmos. Environ., 23(1), 29 (2007). 
  18. M. Q. Man, J. S. Wakefield, T. M. Mauro, and P. M. Elias, Role of nitric oxide in regulating epidermal permeability barrier function, Exp. Dermatol., 31(3), 290 (2022). 
  19. M. M. Cals-Grierson and A. D. Ormerod, Nitric oxide function in the skin, Nitric Oxide, 10(4), 179 (2004). 
  20. D. B. Graves, The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology, J.Phys.D:Appl.Phys., 45(26), 263001 (2012). 
  21. Z. Chen, Y. E. Krasik, S. Cousens, A. T. Ambujakshan, C. Corr, and X. J. Dai, Generation of un derwater discharges inside gas bubbles using a 30-needles-to-plate electrode, J. Appl. Phys., 122(15), 153303 (2017). 
  22. I. Han, Plasma devices for cosmetic and aesthetic treatment, In Plasma Biosciences and Medicine, Singapore: Springer Nature Singapore, 229 (2023). 
  23. B. G. Daniela, R. Thomas, and V. Kolb-Bachofen, Nitric oxide in human skin: current status and future prospects, J Invest Dermatol., 110(1), 1 (1998). 
  24. V. Vijayarangan, S. Dozias, C. Heusele, O. Jeanneton, C. Nizard, C. Pichon, and E. Robert, Boost of cosmetic active ingredient penetration triggered and controlled by the delivery of kHz plasma jet on human skin explants, Front. Phys., 11, 1173349 (2023).