Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Effect of a Mixture of Centella asiatica and Rosamarinus officinalis Leaf Extracts on Delayed Cortisol-induced Keratinocyte Migration

병풀과 로즈마리 잎 추출 혼합물의 코티솔로 유도된 각질형성세포 이동지연에 미치는 영향

  • WonTae Jo (Biospectrum Life Science Institute) ;
  • Miji Yeom (Biospectrum Life Science Institute) ;
  • ShinHwan Cho (Skincure Life Science Institute) ;
  • Eunae Cho (Biospectrum Life Science Institute) ;
  • Deokhoon Park (Biospectrum Life Science Institute) ;
  • Eunsun Jung (Biospectrum Life Science Institute)
  • 조원태 (바이오스펙트럼(주) 생명과학연구소) ;
  • 염미지 (바이오스펙트럼(주) 생명과학연구소) ;
  • 조신환 (스킨큐어(주) 생명과학연구소) ;
  • 조은애 (바이오스펙트럼(주) 생명과학연구소) ;
  • 박덕훈 (바이오스펙트럼(주) 생명과학연구소) ;
  • 정은선 (바이오스펙트럼(주) 생명과학연구소)
  • Received : 2024.05.23
  • Accepted : 2024.06.04
  • Published : 2024.06.30
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Abstract

A key component of wound healing is epithelialization, which involves the proliferation and migration of epidermal keratinocytes surrounding the wound. Increasing cortisol, a stress hormone, is known to slow the healing process by inhibiting cell proliferation and migration. This study aims to develop an ingredient that can promote delayed wound healing by cortisol through a combination of Centella asiatica (C. asiatica), known for its excellent wound healing effect, and Rosamarinus officinalis (R. officinalis) leaf known for their antipsychotic effect. R. officinalis leaf extract was found to inhibit the activity of 11β-HSD1, an enzyme involved in the production of cortisol. A combination of C. asiatica and R. officinalis leaf extracts (AlfaCalm) was found to enhance cortisol induced delayed keratinocyte migration to a greater extent than C. asiatica extract. AlfaCalm enhanced the expression of CDC42 and the formation of filopodia, which are crucial for the relaxation of the actin skeleton. These results suggest that AlfaCalm can be used as an effective wound healing material in stress condition.

각질형성세포의 증식과 이동에 의한 상피화 과정은 빠른 상처 치유에 중요하다. 스트레스 호르몬인 코티솔의 증가는 세포 증식과 이동을 억제하여 치유 과정을 늦추는 것으로 알려져 있다. 본 연구는 뛰어난 상처치유 효능으로 알려진 병풀과 항스트레스성 식물로 알려진 로즈마리와의 복합물을 통해 코티솔에 의해서 지연된 상처치유를 촉진할 수 있는 원료를 개발하고자 한다. 항스트레스성 식물인 로즈마리 잎 추출물은 코티솔의 생산에 관여하는 효소인 11β-HSD1의 활성을 억제함을 확인하였다. 병풀과 로즈마리 잎 추출 혼합물(AlfaCalm)은 병풀 추출물보다 코티솔에 의해 지연된 각질형성세포의 이동을 우수하게 촉진시켰다. AlfaCalm는 actin skeleton의 이완에 중요한 인자인 CDC42 발현과 필로포디아(filopodia)를 증가시켰다. 이 결과를 통해, AlfaCalm이 스트레스 상황에서 상처를 효과적으로 치료하는 소재로 활용될 수 있음을 제시한다.

Keywords

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