Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Anti-Melanogenic Activity of Undecylprodigiosin, a Red Pigment Isolated from a Marine Streptomyces sp. SNA-077

  • Chaeyoung Lee (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Jung Min Park (Department of Beauty and Cosmetic Science, Eulji University) ;
  • Prima F. Hillman (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Minyi Yoo (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Hye Yeon Kim (Department of Beauty and Cosmetic Science, Eulji University) ;
  • Chang-Seok Lee (Department of Beauty and Cosmetic Science, Eulji University) ;
  • Sang-Jip Nam (Department of Chemistry and Nanoscience, Ewha Womans University)
  • Received : 2023.11.28
  • Accepted : 2024.02.14
  • Published : 2024.07.01
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Abstract

Bioassay and HPLC-UV guided fractionations of the crude extract of marine-derived Streptomyces sp. SNA-077 have led to the isolation of a red pigment, undecylprodigiosin (1). The chemical structure of undecylprodigiosin (1) was revealed by the interpretation of NMR and mass spectroscopic (MS) data. Further, anti-melanogenic effects of undecylprodigiosin (1) were investigated. First, the melanin contents of undecylprodigiosin (1)-treated B16 cells were evaluated. Furthermore, undecylprodigiosin (1) significantly inhibited the key enzymes involved in melanogenesis, including tyrosinase, tyrosinase related protein-1 (TYRP-1), and dopachrome tautomerase (DCT). The mRNA and protein expression levels of Microphthalmia-associated transcriptian factor (MiTF), a critical transcription factor for tyrosinase gene expression, were also suppressed by undecylprodigiosin (1) treatment in B16 analyses. Collectively, our results suggest for the first time that undecylprodigiosin (1), a potent component isolated from an extract of marine Streptomyces sp. SNA-077, critically exerts the anti-melanogenic ability for melanin synthesis.

Keywords

Acknowledgement

This research was funded by the National Research Foundation of Korea grant funded by the Korean Government (Ministry of Science and ICT; no. 2021R1A4A2001251 to S.-J.N.), and also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF-2022R1A2C1011848).

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