Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction

  • Bada Lee (Department of Biomedicinal and Pharmaceutical Sciences, Graduate School, Kyung Hee University) ;
  • Soo Min Lee (Department of Biomedicinal and Pharmaceutical Sciences, Graduate School, Kyung Hee University) ;
  • Jae Won Song (Department of Regulatory Science, Graduate School, Kyung Hee University) ;
  • Jin Woo Choi (Department of Biomedicinal and Pharmaceutical Sciences, Graduate School, Kyung Hee University)
  • Received : 2024.01.10
  • Accepted : 2024.05.25
  • Published : 2024.07.01
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Abstract

The human gastrointestinal (GI) tract houses a diverse microbial community, known as the gut microbiome comprising bacteria, viruses, fungi, and protozoa. The gut microbiome plays a crucial role in maintaining the body's equilibrium and has recently been discovered to influence the functioning of the central nervous system (CNS). The communication between the nervous system and the GI tract occurs through a two-way network called the gut-brain axis. The nervous system and the GI tract can modulate each other through activated neuronal cells, the immune system, and metabolites produced by the gut microbiome. Extensive research both in preclinical and clinical realms, has highlighted the complex relationship between the gut and diseases associated with the CNS, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. This review aims to delineate receptor and target enzymes linked with gut microbiota metabolites and explore their specific roles within the brain, particularly their impact on CNS-related diseases.

Keywords

Acknowledgement

This research was supported by Medical Research Center Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF2017R1A5A2014768), grant (21153MFDS601) from Ministry of Food and Drug Safety in 2024, and National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) NRF-2022R1A2C2009281.

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