Advances in nano research

Techno-Press (테크노프레스)
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Screening of nanoemulgels for physicochemical stability and antifungal efficacy

  • Andleeb Fatima (Faculty of Pharmaceutical Sciences, Government College University Faisalabad) ;
  • Muhammad Naeem Aamir (Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur) ;
  • Shahiq-Uz-Zaman (Riphah Institute of Pharmaceutical Sciences, Riphah International University) ;
  • Masood-Ur-Rehman (Riphah Institute of Pharmaceutical Sciences, Riphah International University) ;
  • Zeeshan Javaid (Department of Pharmacy, Mirpur University of Science and Technology) ;
  • Keng Wooi Ng (School of Pharmacy, Faculty of Medical Sciences, Newcastle University) ;
  • Hina Hussain (Institute of Biopharmacy and Pharmaceutical Technology, Martin-Luther University) ;
  • Muhammad Asif (Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur)
  • Received : 2019.10.17
  • Accepted : 2024.04.25
  • Published : 2024.06.25
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Abstract

The nanoemulgel was prepared to induce a synergistic effect along with higher efficacy. Nine sets of macroemulsion were made in which liquid paraffin was stabilized by the two non-ionic surfactants, Tween® 80 and Span® 80. Comparative stability analysis of the macroemulsions was used to determine the effective surfactant concentrations that gave the most stable systems (NE 2, NE3, NE4, NE5). High-speed homogenization was then applied. The final formulation was evaluated for globule size and polydispersablity index, physical properties (color, homogeneity, consistency, syneresis), pH, viscosity, spreadability with 200 g and 500 g weight, conductivity, drug content, stability, skin irritation, antifungal efficacy. Zeta size analysis confirmed the nanosize of the droplets in NE2 (284.8 nm), NE3 (79.89 nm), NE4 (194 nm) but not NE5 (632.8 nm), which was outside the nanoemulsion range. The antifungal assay exhibited zone of inhibition for NE3 (43±1.0 mm) and NE4 (42±1.7 mm), a marketed cream (33±1 mm), fluconazole alone (35±1 mm) and terbinafine alone (35.0±1.7 mm). The zone of inhibition of nanoemulgels increased compared with the drugs when used individually and when compared a placebo.

Keywords

References

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