한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제41권2호
  • /
  • Pages.447-458
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  • 2024
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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Antioxidant activity of 3,5-dicaffeoyl-epi-quinic acid (DEQA) from the halophyte Atriplex gmelinii

  • Hojun Kim (Division of Convergence on Marine Science, Korea Maritime & Ocean University) ;
  • Chang-Suk Kong (Department of Food and Nutrition, College of Medical and Life Sciences, Silla University) ;
  • Youngwan Seo (Division of Convergence on Marine Science, Korea Maritime & Ocean University)
  • 투고 : 2024.03.25
  • 심사 : 2024.04.26
  • 발행 : 2024.04.30
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초록

In this study, the antioxidizing effect of 2,3-dicaffeoyl-epi-quinic acid (DEQA) was investigated. The antioxidant activity was evaluated by measuring the scavenging effect on DPPH radical and peroxynitrite and the reducing power on ferric ion. DEQA showed a scavenging effect and reducing power comparable to vitamin C used as a positive control. Also, DEQA effectively inhibited production of intracellular reactive oxygen species (ROS) in HT-1080 cells, showing the scavenging ratio of 43.8% even at 10 µM concentration of DEQA after 2 hours in HT-1080 treated with H2O2. In addition to this, DEQA inhibited the production of nitric oxide (NO) very effectively in Raw 264.7 cells. The above results suggest that DEQA has the potential to be developed as a natural antioxidant.

키워드

과제정보

This study is outcome of the Basic Science Research Program (No. 2019R1F1A1059325 and 2022R1F1A1065328) conducted with the support of the National Research Foundation of Korea, funded by the Ministry of Science and ICT.

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