통합자연과학논문집 (Journal of Integrative Natural Science)

조선대학교 기초과학연구원 (The Basic Science Institute Chosun University)
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Maqui Berry Extract Activates Dendritic Cells Maturation by Increasing the Levels of Co-stimulatory Molecules and IL-12 Production

  • Ye Eun Lim (Department of Life Science, Immunology Research Lab, Institute of Well-Aging Medicare & CSU G-LAMP Project Group, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University) ;
  • Inae Jung (Department of Life Science, Immunology Research Lab, Institute of Well-Aging Medicare & CSU G-LAMP Project Group, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University) ;
  • Mi Eun Kim (Department of Life Science, Immunology Research Lab, Institute of Well-Aging Medicare & CSU G-LAMP Project Group, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University) ;
  • Jun Sik Lee (Department of Life Science, Immunology Research Lab, Institute of Well-Aging Medicare & CSU G-LAMP Project Group, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University)
  • 투고 : 2024.06.10
  • 심사 : 2024.06.12
  • 발행 : 2024.06.28
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초록

Dendritic cells play a very important role in the immune response as antigen-presenting cells that are critical for initiating both innate and acquired immunity. They recognize, process and present foreign antigens to other key immune cells to trigger and regulate the immune response. The ability to activate these dendritic cells can be used as a treatment for various immune diseases. Maqui berry has been reported to have anticancer, antibacterial and anti-inflammatory properties. However, its effect on the activity of dendritic cells has not been studied. In this study, we investigated the efficacy of maqui berry extract in modulating dendritic cell activity. Treatment of dendritic cells with maqui berry extract induced the costimulatory molecules CD80, CD86, and MHC class I and II in a concentration-dependent manner. Furthermore, the antigen-presenting capacity of dendritic cells was inhibited, which confirms their ability to present antigens, and the production of Interleukin (IL)-12, which is important for dendritic cell activity, was increased. These results indicated that Maqui berry extract activates dendritic cells maturation by inducing the production of co-stimulatory molecules and IL-12. These results suggest that maqui berry extract may act as an effective adjuvant to enhance dendritic cell-based immune responses.

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