The Korean Journal of Nuclear Medicine Technology (핵의학기술)

The Korean Society of Nuclear Medicine Technology (대한핵의학기술학회)
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The Effect of Contrast Agent on the Change of Hepatic Uptake of 99mTc-Mebrofenin in Patients with Liver Transplantation

  • Seung-Hun Yeom (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Sang-Hyeong Kil (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Yeong-Hyeon Lim (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Gwang-Yeol Park (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Gyeong-Nam Cho (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Seong-Muk Cho (Department of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Ji-Ho Seong (Department of Nuclear Medicine, Pusan National University Yangsan Hospital)
  • Received : 2024.03.25
  • Accepted : 2024.05.08
  • Published : 2024.05.30
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Abstract

Purpose: 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) is an important and clinically useful diagnostic imaging study for detecting complications after liver transplantation. CT contrast agents due to their high atomic numbers, lead to a decrease in gamma ray count rates. This study investigated the impact of CT contrast agents on the uptake of 99mTc-mebrofenin in the liver. Materials and Methods: The quantitative HBS was performed on sixty-two liver transplantation patients (male:female=36:26), with a mean age of 59.4±6.4 years. Statistical comparison of hepatic uptake reduction ratio (HURR%) before and after the injection of CT contrast agents was performed using a paired t-test. Results: Hepatic uptake of the reduction ratio was 94.47±3.65% for the pre-CT contrast agents and 92.17±4.00% for the post-CT contrast agents. HURR% after CT contrast agent injection showed a statistically significant difference compared to before the injection (t=11.09, P<0.001). Conclusion: It will be necessary to pay attention when examining the HBS of patients with liver transplantation after the injection of CT contrast medium. It is advisable to schedule the examination on a different day to prevent residual contrast medium in the body from interfering with the quantitative evaluation of the nuclear medicine examination.

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