대한융합한의학회지 (Journal of Convergence Korean Medicine)

대한융합한의학회 (Academy of Convergence Korean Medicine)
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캐롭 추출물을 활용한 경옥고의 항산화, 항염증 효과 증진

Improvement of Antioxidant and Anti-inflammatory Effects of Gyeongokgo Using Carop Extract

  • 이성진 (경희대학교 동서의학대학원 동서의학과) ;
  • 인창식 (경희대학교 한의과대학 한의교육학교실)
  • Sungjin Lee (East-west Medicine Graduate School of East-west Medical Science Kyung Hee University) ;
  • Chang Shik Yin (Department of Medical Education, College of Korean Medicine, Kyung Hee University)
  • 발행 : 2024.06.30
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초록

Objectives: Gyeongokgo is a traditional medicine typically used for individuals with wasting disorders and decreased immunity. Carop is well-known for its exceptional antioxidant effects. The objective of this study was to determine whether the antioxidant and anti-inflammatory properties of Gyeongokgo may be enhanced by the addition of carob. Methods: Cytotoxicity was confirmed using an MTT assay. Free radical scavenging activity ability was evaluated using DPPH assay. The amount of produced nitrogen oxide, TNF-α, and IL-6 were measured using an ELISA reader. Results: The Gyeongokgo with carob showed no cytotoxicity and a synergistic effect on antioxidant activity, when compared with the Gyeongokgo without carob. In addition, the inhibitory effect on nitric oxide production was higher for the Gyeongokgo with carob when compared with the Gyeongokgo without carob. The anti-inflammatory response of the Gyeongokgo with carob was possibly through the suppression of the production of TNF-α and IL-6. Conclusion: The addition of carob to Gyeongokgo may be an effective measure to enhance the antioxidant and anti-inflammatory effects.

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