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Incidence and Risk Factors of Acute Ischemic Cholecystitis after Transarterial Chemoembolization: Correlation with Cone Beam CT Findings

간동맥 화학 색전술 후 발생한 급성 담낭염의 발생률과 위험인자: Cone Beam CT 소견과의 상관관계

  • Jong Yeong Kim (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jung Suk Oh (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Ho Jong Chun (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Su Ho Kim (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 김종영 (가톨릭대학교 의과대학 서울성모병원 영상의학과) ;
  • 오정석 (가톨릭대학교 의과대학 서울성모병원 영상의학과) ;
  • 천호종 (가톨릭대학교 의과대학 서울성모병원 영상의학과) ;
  • 김수호 (가톨릭대학교 의과대학 서울성모병원 영상의학과)
  • Received : 2023.07.10
  • Accepted : 2023.09.08
  • Published : 2024.03.01

Abstract

Purpose Acute cholecystitis is a complication of transarterial chemoembolization (TACE) that occasionally requires surgical intervention. We aimed to analyze the incidence and risk factors of cholecystitis requiring surgical intervention in patients with embolic material uptake on cone beam CT (CBCT) performed immediately after various TACE procedures. Materials and Methods After a retrospective review of 2633 TACE procedures performed over a 6-year period, 120 patients with embolic material retention in the gallbladder wall on CBCT immediately after TACE were selected. We analyzed the incidence of and risk factors for acute cholecystitis. Results The overall incidence of acute cholecystitis requiring surgical intervention was 0.45% (12 of 2633 TACE procedures); however, it was present in 10% (12 of 120) of procedures that showed high-density embolic material retention in the gallbladder wall on CBCT performed immediately after TACE. Acute cholecystitis requiring surgical intervention occurred in eight patients (66.7%) who underwent direct cystic arterial embolization. Surgical intervention was performed 15 days (mean) after TACE. Conclusion Most unintended chemolipiodol deposits in the gallbladder wall resolved without intervention or surgery. However, superselective direct cystic arterial chemoembolization was associated with a high incidence of acute cholecystitis requiring surgery, and patients who undergo this procedure should be closely monitored.

목적 급성 담낭염은 간동맥 화학 색전술 후에 발생하는 비교적 드물지 않게 발생하는 합병증이며, 대부분 수술적 혹은 중재적 치료 없이 호전된다. 간동맥 화학 색전술 직후에 촬영한 cone beam CT 소견을 이용하여, 수술적 혹은 중재적 치료를 필요로 하는 담낭염의 발생률과 위험인자를 분석하고자 하였다. 대상과 방법 본 연구에서는 6년 동안 시행된 2633건의 간동맥 화학 색전술에 대해 후향적으로 분석하였다. 그중 시술 직후에 촬영한 cone beam CT에서 담낭에 색전 물질이 남아 있는 120명을 선택하여 급성 담낭염의 발생률과 위험인자에 대해 분석하였다. 결과 수술적 혹은 중재적 치료를 필요로 하는 담낭염의 전체 발생률은 0.45%였다. 색전 물질이 남아 있는 환자들 중에서는 10%에서 담낭염이 발생했다. 담낭염이 발생한 12명 중 8명은 담낭동맥의 색전술을 받은 환자들이었다. 결론 대부분의 담낭의 색전물질 침적은 추가적인 치료를 필요로 하지 않고 호전되지만, 담낭동맥의 색전술을 받은 경우에는 담낭염의 발생률이 높아 면밀한 모니터링이 필요하다.

Keywords

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