Acknowledgement
This research was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (NRF-2022R1F1A1071248) and the Chung-Ang University Research Scholarship Grants in 2021.
References
- Biehl JK and Russell B (2009) Introduction to stem cell therapy. J Cardiovasc Nurs 24, 98-103 https://doi.org/10.1097/JCN.0b013e318197a6a5
- Macrin D, Joseph JP, Pillai AA and Devi A (2017) Eminent sources of adult mesenchymal stem cells and their therapeutic imminence. Stem Cell Rev Rep 13, 741-756 https://doi.org/10.1007/s12015-017-9759-8
- Si Z, Wang X, Sun C et al (2019) Adipose-derived stem cells: sources, potency, and implications for regenerative therapies. Biomed Pharmacother 114, 108765
- Zuk PA, Zhu M, Mizuno H et al (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7, 211-228 https://doi.org/10.1089/107632701300062859
- Fraser JK, Wulur I, Alfonso Z and Hedrick MH (2006) Fat tissue: an underappreciated source of stem cells for biotechnology. Trends Biotechnol 24, 150-154 https://doi.org/10.1016/j.tibtech.2006.01.010
- Kasir R, Vernekar VN and Laurencin CT (2015) Regenerative engineering of cartilage using adipose-derived stem cells. Regen Eng Transl Med 1, 42-49 https://doi.org/10.1007/s40883-015-0005-0
- Pak J, Lee JH, Pak N et al (2018) Cartilage regeneration in humans with adipose tissue-derived stem cells and adipose stromal vascular fraction cells: updated status. Int J Mol Sci 19, 2146
- Meng HY, Lu V and Khan W (2021) Adipose tissue-derived mesenchymal stem cells as a potential restorative treatment for cartilage defects: a PRISMA review and meta-analysis. Pharmaceuticals (Basel) 14, 1280
- Varghese J, Griffin M, Mosahebi A and Butler P (2017) Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy. Stem Cell Res Ther 8, 45
- Bunnell BA (2021) Adipose tissue-derived mesenchymal stem cells. Cells 10, 3433
- Liu X, Xiang Q, Xu F et al (2019) Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells. Sci Data 6, 190031
- Yang S, Cho Y and Jang J (2021) Single cell heterogeneity in human pluripotent stem cells. BMB Rep 54, 505-515 https://doi.org/10.5483/BMBRep.2021.54.10.094
- Ziegenhain C, Vieth B, Parekh S et al (2017) Comparative analysis of single-cell RNA sequencing methods. Mol Cell 65, 631-643 https://doi.org/10.1016/j.molcel.2017.01.023
- Zhou WM, Yan YY, Guo QR et al (2021) Microfluidics applications for high-throughput single cell sequencing. J Nanobiotechnology 19, 312
- Macosko EZ, Basu A, Satija R et al (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 https://doi.org/10.1016/j.cell.2015.05.002
- Stromps JP, Paul NE, Rath B, Nourbakhsh M, Bernhagen J and Pallua N (2014) Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management? Biomed Res Int 2014, 740926
- Xu J, Wang W, Ludeman M et al (2008) Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels. Tissue Eng Part A 14, 667-680 https://doi.org/10.1089/tea.2007.0272
- Ilicic T, Kim JK, Kolodziejczyk AA et al (2016) Classification of low quality cells from single-cell RNA-seq data. Genome Biol 17, 29
- Bock FJ and Tait SWG (2020) Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol 21, 85-100 https://doi.org/10.1038/s41580-019-0173-8
- Singh AM (2015) Cell cycle-driven heterogeneity: on the road to demystifying the transitions between "poised" and "restricted" pluripotent cell states. Stem Cells Int 2015, 219514
- Tirosh I, Izar B, Prakadan SM et al (2016) Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189-196 https://doi.org/10.1126/science.aad0501
- Hou W, Duan L, Huang C et al (2021) Cross-tissue characterization of heterogeneities of mesenchymal stem cells and their differentiation potentials. Front Cell Dev Biol 9, 781021
- Leung VY, Gao B, Leung KK et al (2011) SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet 7, e1002356
- Ruijtenberg S and van den Heuvel S (2016) Coordinating cell proliferation and differentiation: antagonism between cell cycle regulators and cell type-specific gene expression. Cell Cycle 15, 196-212 https://doi.org/10.1080/15384101.2015.1120925
- Gabut M, Bourdelais F and Durand S (2020) Ribosome and translational control in stem cells. Cells 9, 497
- Yan W, Diao S and Fan Z (2021) The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells. Stem Cell Res Ther 12, 140
- Nolfi-Donegan D, Braganza A and Shiva S (2020) Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement. Redox Biol 37, 101674
- Zhang Y, Marsboom G, Toth PT and Rehman J (2013) Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells. PLoS One 8, e77077
- Shum LC, White NS, Mills BN, Bentley KL and Eliseev RA (2016) Energy metabolism in mesenchymal stem cells during osteogenic differentiation. Stem Cells Dev 25, 114-122 https://doi.org/10.1089/scd.2015.0193