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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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3D epigenomics and 3D epigenopathies

  • Kyung-Hwan Lee (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ;
  • Jungyu Kim (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology) ;
  • Ji Hun Kim (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)
  • Received : 2023.12.04
  • Accepted : 2024.03.18
  • Published : 2024.05.31
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Abstract

Mammalian genomes are intricately compacted to form sophisticated 3-dimensional structures within the tiny nucleus, so called 3D genome folding. Despite their shapes reminiscent of an entangled yarn, the rapid development of molecular and next-generation sequencing technologies (NGS) has revealed that mammalian genomes are highly organized in a hierarchical order that delicately affects transcription activities. An increasing amount of evidence suggests that 3D genome folding is implicated in diseases, giving us a clue on how to identify novel therapeutic approaches. In this review, we will study what 3D genome folding means in epigenetics, what types of 3D genome structures there are, how they are formed, and how the technologies have developed to explore them. We will also discuss the pathological implications of 3D genome folding. Finally, we will discuss how to leverage 3D genome folding and engineering for future studies.

Keywords

Acknowledgement

This study was supported by the KAIST UP Program, and a Medical Scientist Training Program, and the National Research Foundation of Korea (NRF) grant from the Ministry of Science & ICT of Korea (RS-2024-00334460).

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