동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제38권1호
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  • Pages.1-9
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  • 2024
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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인지예비능의 신경적 기질에 대한 서술적 문헌고찰 연구 : 휴지기 기능적 자기공명영상 연구를 중심으로

A Narrative Literature Review on the Neural Substrates of Cognitive Reserve: Focusing on the Resting-state Functional Magnetic Resonance Imaging Studies

  • 신현상 (상지대학교 한의과대학 해부학교실 ) ;
  • 성우현 (상지대학교 한의과대학 해부학교실 ) ;
  • 권보인 (상지대학교 한의과대학 병리학교실) ;
  • 우연주 (상지대학교 한의과대학 생리학교실) ;
  • 김주희 (상지대학교 한의과대학 침구의학교실) ;
  • 이동혁 (상지대학교 한의과대학 해부학교실)
  • Hyeonsang Shin (Department of Anatomy, College of Korean Medicine, Sangji University) ;
  • Woohyun Seong (Department of Anatomy, College of Korean Medicine, Sangji University) ;
  • Bo-in Kwon (Department of Pathology, College of Korean Medicine, Sangji University) ;
  • Yeonju Woo (Department of Physiology, College of Korean Medicine, Sangji University) ;
  • Joo-Hee Kim (Department of Acupuncture & Moxibustion, College of Korean Medicine, Sangji University) ;
  • Dong Hyuk Lee (Department of Anatomy, College of Korean Medicine, Sangji University)
  • 투고 : 2023.11.16
  • 심사 : 2024.01.17
  • 발행 : 2024.02.25
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초록

Cognitive reserve (CR) is a concept that can explain the discrepancies between the pathologic burden of the disease and clinical manifestations. It refers to the individual susceptibility to age-related brain changes and pathologies related to Alzheimer's disease, thus recognized as a factor affecting the trajectories of the disease. The purpose of this study was to explore the current states of clinical studies on neural substrates of CR in Alzheimer's disease using functional magnetic resonance imaging. We searched for clinical studies on CR using fMRI in the Pubmed, Cochrane library, RISS, KISS and ScienceON on August 14, 2023. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of CR. Total thirty-four studies were included in this study. As surrogate markers of CR, not only education and occupational complexity, but also composite score and questionnaire-based method, which cover various areas of life, were mainly used. The most utilized methods in resting-state fMRI were independent component analysis, seed-based analysis, and graph theory analysis. Through the analysis, we demonstrated that neuroimaging techniques could capture the neural substrates associated with cognitive reserve. Moreover, functional connectivity of brain regions centered on prefrontal and parietal cortex and network areas such as default mode network showed a significant correlation with CR, which indicated a significant association with cognitive performance. CR may induce differential effects according to the disease status. We hope that this perspective on cognitive reserve would be helpful when conducting clinical researches on the mechanisms of traditional Korean medicine for Alzheimer's disease in the future.

키워드

과제정보

이 성과는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구입니다(No. NRF-2022R1F1A1061004). 또한 2023년도 교육부의 재원으로 한국연구재단의 지원을 받아 수행된 지자체-대학 협력 기반 지역혁신사업의 결과입니다(2022RIS-005).

참고문헌

  1. Elahi FM, Miller BL. A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol. 2017 Aug;13(8):457-76.  https://doi.org/10.1038/nrneurol.2017.96
  2. Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-62.  https://doi.org/10.1016/j.jalz.2018.02.018
  3. Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012 Nov;11(11):1006-12.  https://doi.org/10.1016/S1474-4422(12)70191-6
  4. Ko K, Yi D, Byun MS, Lee JH, Jeon SY, Kim WJ, et al. Cognitive reserve proxies, Alzheimer pathologies, and cognition. Neurobiol Aging. 2022 Feb;110:88-95  https://doi.org/10.1016/j.neurobiolaging.2021.10.005
  5. Li X, Cai L, Jiang X, Liu X, Wang J, Yang T, et al. Resting-State fMRI in Studies of Acupuncture. Evid Based Complement Alternat Med. 2021 Mar 23;2021:6616060. 
  6. Soldan A, Moghekar A, Walker KA, Pettigrew C, Hou X, Lu H, et al. Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults. Front Aging Neurosci. 2019 Jun 7;11:132. 
  7. Soldan A, Pettigrew C, Zhu Y, Wang MC, Bilgel M, Hou X, et al. Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults. Cereb Cortex. 2021 Oct 22;31(12):5637-51.  https://doi.org/10.1093/cercor/bhab187
  8. Soldan A, Alfini A, Pettigrew C, Faria A, Hou X, Lim C, et al. Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults. Neurobiol Aging. 2022 Aug;116:32-40.  https://doi.org/10.1016/j.neurobiolaging.2022.04.006
  9. Pietzuch M, Bindoff A, Jamadar S, Vickers JC. Interactive effects of the APOE and BDNF polymorphisms on functional brain connectivity: the Tasmanian Healthy Brain Project. Sci Rep. 2021 Jul 15;11(1):14514. 
  10. Nucci M, Mapelli D, Mondini S. Cognitive Reserve Index questionnaire (CRIq): a new instrument for measuring cognitive reserve. Aging Clin Exp Res. 2012 Jun;24(3):218-26.  https://doi.org/10.1007/BF03654795
  11. Ersoezlue E, Rauchmann BS, Schneider-Axmann T, Wagner M, Ballarini T, Tato M, et al. Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease. Neurobiol Aging. 2023 Feb;122:33-44.  https://doi.org/10.1016/j.neurobiolaging.2022.05.015
  12. Benson G, Hildebrandt A, Lange C, Schwarz C, Kobe T, Sommer W, et al. Functional connectivity in cognitive control networks mitigates the impact of white matter lesions in the elderly. Alzheimers Res Ther. 2018 Oct 27;10(1):109. 
  13. Marin-Marin L, Palomar-Garcia MA, Miro-Padilla A, Adrian-Ventura J, Aguirre N, Villar-Rodriguez E, et al. Bilingualism's Effects on Resting-State Functional Connectivity in Mild Cognitive Impairment. Brain Connect. 2021 Feb;11(1):30-7.  https://doi.org/10.1089/brain.2020.0877
  14. Martijn P. van den Heuvel, Hilleke E. Hulshoff Pol. Exploring the brain network: A review on resting-state fMRI functional connectivity, European Neuropsychopharmacology, Volume 20, Issue 8, 2010, Pages 519-34.  https://doi.org/10.1016/j.euroneuro.2010.03.008
  15. Smitha KA, Akhil Raja K, Arun KM, Rajesh PG, Thomas B, Kapilamoorthy TR, et al. Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks. Neuroradiol J. 2017 Aug;30(4):305-17.  https://doi.org/10.1177/1971400917697342
  16. Jiang J, Liu T, Crawford JD, Kochan NA, Brodaty H, Sachdev PS, et al. Stronger bilateral functional connectivity of the frontoparietal control network in near-centenarians and centenarians without dementia. Neuroimage. 2020 Jul 15;215:116855. 
  17. Zhu W, Li X, Li X, Wang H, Li M, Gao Z, et al. The protective impact of education on brain structure and function in Alzheimer's disease. BMC Neurol. 2021 Oct 30;21(1):423. 
  18. Liu Y, Wang K, Yu C, He Y, Zhou Y, Liang M, et al. Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: a review of resting-state fMRI studies. Neuropsychologia. 2008;46(6):1648-56.  https://doi.org/10.1016/j.neuropsychologia.2008.01.027
  19. Saxe GN, Calderone D, Morales LJ. Brain entropy and human intelligence: A resting-state fMRI study. PLoS One. 2018 Feb 12;13(2):e0191582. 
  20. Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, et al. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain. 2021 Aug 17;144(7):2176-85. 
  21. Caldwell JZK, Zhuang X, Leavitt MJ, Banks SJ, Cummings J, Cordes D, et al. Sex Moderates Amyloid and Apolipoprotein ε4 Effects on Default Mode Network Connectivity at Rest. Front Neurol. 2019 Aug 20;10:900. 
  22. Li X, Zhou S, Zhu W, Li X, Gao Z, Li M, et al. Sex Difference in Network Topology and Education Correlated With Sex Difference in Cognition During the Disease Process of Alzheimer. Front Aging Neurosci. 2021 Jun 3;13:639529. 
  23. Du W, Ding C, Jiang J, Han Y. Women Exhibit Lower Global Left Frontal Cortex Connectivity Among Cognitively Unimpaired Elderly Individuals: A Pilot Study from SILCODE. J Alzheimers Dis. 2021;83(2):653-63.  https://doi.org/10.3233/JAD-210376
  24. Li T, Wang B, Gao Y, Wang X, Yan T, Xiang J, et al. APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum. Brain Imaging Behav. 2021 Apr;15(2):758-71.  https://doi.org/10.1007/s11682-020-00283-w
  25. Bozzali M, Dowling C, Serra L, Spano B, Torso M, Marra C, et al. The impact of cognitive reserve on brain functional connectivity in Alzheimer's disease. J Alzheimers Dis. 2015;44(1):243-50.  https://doi.org/10.3233/JAD-141824
  26. Franzmeier N, Gottler J, Grimmer T, Drzezga A, Araque-Caballero MA, Simon-Vermot L, et al. Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment. Front Aging Neurosci. 2017 Aug 7;9:264. 
  27. Ye Q, Zhu H, Chen H, Liu R, Huang L, Chen H, et al. Effects of cognitive reserve proxies on cognitive function and frontoparietal control network in subjects with white matter hyperintensities: A cross-sectional functional magnetic resonance imaging study. CNS Neurosci Ther. 2022 Jun;28(6):932-41.  https://doi.org/10.1111/cns.13824
  28. Weiler M, Casseb RF, de Campos BM, de Ligo Teixeira CV, Carletti-Cassani AFMK, Vicentini JE, et al. Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease. Front Aging Neurosci. 2018 Aug 21;10:255. 
  29. Kim Y, Kim SW, Seo SW, Jang H, Kim KW, Cho SH, et al. Effect of education on functional network edge efficiency in Alzheimer's disease. Sci Rep. 2021 Aug 26;11(1):17255. 
  30. Wang Z; Alzheimer's Disease Neuroimaging Initiative. Brain Entropy Mapping in Healthy Aging and Alzheimer's Disease. Front Aging Neurosci. 2020 Nov 10;12:596122. 
  31. Serra L, Mancini M, Cercignani M, Di Domenico C, Spano B, Giulietti G, et al. Network-Based Substrate of Cognitive Reserve in Alzheimer's Disease. J Alzheimers Dis. 2017;55(1):421-30. 
  32. Franzmeier N, Buerger K, Teipel S, Stern Y, Dichgans M, Ewers M, et al. Cognitive reserve moderates the association between functional network anti-correlations and memory in MCI. Neurobiol Aging. 2017 Feb;50:152-62.  https://doi.org/10.1016/j.neurobiolaging.2016.11.013
  33. Dautricourt S, Gonneaud J, Landeau B, Calhoun VD, de Flores R, Poisnel G, et al. Dynamic functional connectivity patterns associated with dementia risk. Alzheimers Res Ther. 2022 May 23;14(1):72. 
  34. Franzmeier N, Caballero MAA, Taylor ANW, Simon-Vermot L, Buerger K, Ertl-Wagner B, et al. Resting-state global functional connectivity as a biomarker of cognitive reserve in mild cognitive impairment. Brain Imaging Behav. 2017 Apr;11(2):368-82.  https://doi.org/10.1007/s11682-016-9599-1
  35. Franzmeier N, Duering M, Weiner M, Dichgans M, Ewers M; Alzheimer's Disease Neuroimaging Initiative (ADNI). Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease. Neurology. 2017 Mar 14;88(11):1054-61.  https://doi.org/10.1212/WNL.0000000000003711
  36. Franzmeier N, Duzel E, Jessen F, Buerger K, Levin J, Duering M, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain. 2018 Apr 1;141(4):1186-200.  https://doi.org/10.1093/brain/awy008
  37. Neitzel J, Franzmeier N, Rubinski A, Ewers M; Alzheimer's Disease Neuroimaging Initiative (ADNI). Left frontal connectivity attenuates the adverse effect of entorhinal tau pathology on memory. Neurology. 2019 Jul 23;93(4):e347-57. 
  38. Chen H, Zhu H, Huang L, Chen H, Liu R, Qin R, et al. The flexibility of cognitive reserve in regulating the frontoparietal control network and cognitive function in subjects with white matter hyperintensities. Behav Brain Res. 2022 May 3;425:113831. 
  39. Chirles TJ, Reiter K, Weiss LR, Alfini AJ, Nielson KA, Smith JC. Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders. J Alzheimers Dis. 2017;57(3):845-56.  https://doi.org/10.3233/JAD-161151
  40. Liu T, Spector A, Mograbi DC, Cheung G, Wong GHY. Changes in Default Mode Network Connectivity in Resting-State fMRI in People with Mild Dementia Receiving Cognitive Stimulation Therapy. Brain Sci. 2021 Aug 27;11(9):1137. 
  41. Lv T, You S, Qin R, Hu Z, Ke Z, Yao W, et al. Distinct reserve capacity impacts on default-mode network in response to left angular gyrus-navigated repetitive transcranial magnetic stimulation in the prodromal Alzheimer disease. Behav Brain Res. 2023 Feb 15;439:114226. 
  42. Breijyeh Z, Karaman R. Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules. 2020 Dec 8;25(24):5789. doi: 10.3390/molecules25245789. 
  43. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, et al. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Annals of Neurology. 1988;23:138-44  https://doi.org/10.1002/ana.410230206
  44. Serrano-Pozo A, Das S, Hyman BT. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. Lancet Neurol. 2021 Jan;20(1):68-80.  https://doi.org/10.1016/S1474-4422(20)30412-9
  45. Preventive Korean Medicine Textbook Compilation Committee. Preventive Korean Medicine. 3rd edition. Seoul:Gyechuk Munwhasa;2012:578-82.