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Review on Weight Loss Interventions that Can Prevent Muscle Mass Loss in Sarcopenic Obesity

근감소성 비만에 대하여 근육량을 보존할 수 있는 체중 감량 중재에 대한 고찰

  • Received : 2023.11.24
  • Accepted : 2024.02.16
  • Published : 2024.03.01

Abstract

Objectives: The objective of this study was to review clinical studies conducted over the last ten years that investigated weight or fat loss interventions that can preserve muscle or fat-free mass in Sarcopenic obesity Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Research Information Sharing Service (RISS) and Korea Studies Information Service (KISS) were searched for Randomized clinical trials that had investigated all-type of interventions on the management of sarcopenic obesity from October 2013 to September 2023. Results: A total of 14 studies met all the inclusion criteria. Interventions that increase muscle mass while reducing body fat at the same time included resistance training (including using elastic bands) and whole-body electromyostimulation(WB-EMS) in exercise intervention and Hypocaloric high-protein diet in nutritional intervention, exercise and nutritional combined intervention, and combination intervention of electrical acupuncture and amino acid supplementation. Among them, the most positive method of changing the body composition in sarcopenic obesity was the electric acupuncture and amino acid supplements. Conclusion: Varying diagnostic criteria and management interventions for sarcopenic obesity in the included studies made it hard to maintain homogeneity across the studies. Well-defined criteria for diagnostic sarcopenic obesity should be considered. In addition, since all of the interventions examined did not show sufficient clinical effectiveness, follow-up studies are needed to confirm effective interventions for sarcopenic obesity patients in the future.

Keywords

References

  1. Cruz-Jentoft, A. J., & Sayer, A. A. (2019). Sarcopenia. Lancet, 393, 2636-2646. https://doi.org/10.1016/S0140-6736(19)31138-9 
  2. Baek, J. Y., Lee, E., Jung, H. W., & Jang, I. Y. (2021). Geriatrics fact sheet in Korea. Ann Geriatr Med Res, 25, 65-71. https://doi.org/10.4235/agmr.21.0063 
  3. Donini, L.M., Busetto, L., Bischoff, S.C., Tommy, C., Maria, D.B., John, A.B., ... & Rocco, B. (2022). Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement. Obes Fact, 15(3), 321-335. https://doi.org/10.1159/000521241 
  4. Hong, S. H., & Choi, K. M. (2020). Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. Int J Mol Sci, 21(2), 494. https://doi.org/10.3390/ijms21020494 
  5. Zhang, X., Xie, X., Dou, Q., Liu, C., Zhang, W., Yang, Y., ... & Andy, S. K. (2019). Association of sarcopenic obesity with the risk of all-cause mortality among adult over a broad range of different settings: a updated meta-analysis. BMC Geriatr, 19(1), 183. https://doi.org/10.1186/s12877-019-1195-y 
  6. Chaoran, L., Pui, Y. W., Yik, L. C., Simon, K. C., Wing, H. C., Sheung, W. L., ... & Ronald, M. Y. (2023). Deciphering the "obesity pardox" in the elderly: A systematic review and meta-analysis of sarcopenic obesity. Obes Rev, 24(2), e13534. https://doi.org/10.1111/obr.13534 
  7. Goisser, S., Kemmler, W., Porzel, S., Volkert, D., Sieber, C.C., Bollheimer, L.C., & Freiberger, E. (2015) Sarcopenic obesity and complex interventions with nutrition and exercise incommunity-dwelling older persons-a narrative review. Clin Interv Aging, 10, 1267. https://doi.org/10.2147/CIA.S82454 
  8. Poggiogalle, E., Migliaccio, S., Lenzi, A., & Donini, L. (2014). Treatment of body composition changes in obese and overweight older adults: insight into the phenotype of sarcopenic obesity. Endocrine, 47(3), 699-716. https://doi.org/10.1007/s12020-014-0315-x 
  9. Hit-contreras, F. H., Bueno-Notivol, J., Martinez-Amat, A., Cruz-Diaz, D., Hernadez, A. V., & Perez-Lopez, F. R. (2018). Effect of exercise alone or combined with dietary supplements on anthropometric and physical performance measures in community-dwelling elderly people with sarcopenic obesity: a meta-analysis of randomized controlled trials. Maturitas, 116, 24-35. https://doi.org/10.1016/j.maturitas.2018.07.007 
  10. Eglseer, D., Traxler, M., Schoufour, J. D., Weijs, P. J., Voortman, T., Boirie, Y., ... & Bouer, S; SO-NUT Consortium. (2023). Nutritional and exercise interventions in individuals with sarcopenic obesity around retirement age: a systematic review and meta-analysis. Nutr Rev, 81(9), 1077-1090. https://doi.org/10.1093/nutrit/nuad007 
  11. Bosy, W. A., & Muller, M. J. (2014). Measuring the impact of weight cycling on body composition: a methodological challenge. Curr Opin Clin Nutr Metab Care, 17, 396-400. https://doi.org/10.1097/MCO.0000000000000092 
  12. Balachandran, A., Krawczyk, S. N., Potiaumpai, M., & Signorile, J. F. (2014). High-speed circuit training vs hypertrophy training to improve physical function in sarcopenic obese adults: a randomized controlled trial. Exp Gerontol, 60, 64-71. https://doi.org/10.1016/j.exger.2014.09.016 
  13. Gadelha, A. B., Paiva, F. M., Gauche, R., de Oliveira, R. J., & Lima, R. M. (2016). Effects of resistance training on sarcopenic obesity index in older women: a randomized controlled trial. Arch Gerontol Geriatr, 65, 168-173. https://doi.org/10.1016/j.archger.2016.03.017. 
  14. Chen, H. T., Chung, Y. C., Chen, Y. J., Ho, S. Y., & Wu, H. J. (2017). Effects of different types of exercise on body composition, muscle strength, and IGF-1 in the elderly with sarcopenic obesity. J. Am. Geriatr. Soc, 65(4), 827832. https://doi.org/10.1111/jgs.14722 
  15. Park, J., Kwon, Y., & Park, H. (2017). Effects of 24-week aerobic and resistance training on carotid artery intima-media thickness and flow velocity in elderly women with sarcopenic obesity. J. Atheroscler. Thromb, 24 (11), 1117-1124. https://doi.org/10.5551/jat.39065 
  16. Huang, S. W., Ku, J. W., Lin, L. F., Liao, C. D., Chou, L. C., & Liou, T. H. (2017). Body composition influenced by progressive elastic band resistance exercise of sarcopenic obesity elderly women: a pilot randomized controlled trial. European Journal of Physical and Rehabilitation Medicine, 53(4), 556-563. https://doi.org/10.23736/S1973-9087.17.04443-4 
  17. Liao, C. D., Tsauo, J. Y., Lin, L. F., Huang, S. W., Ku, J. W., Chou, L. C., & Liou, T. H. (2017). Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity: a CONSORT-compliant prospective randomized controlled trial. Medicine, 96, 23. https://doi.org/10.1097/MD.0000000000007115. 
  18. Muscariello, E., Nasti, G., Siervo, M., Di Maro, M., Lapi, D., D'Addio, G., & Colantuoni, A. (2016). Dietary protein intake in sarcopenic obese older women.(ORIGINAL RESEARCH). Clin. Interv. Aging, 11, 133. https://doi.org/10.2147/CIA.S96017 
  19. Sammarco, R., Marra, M., Di Guglielmo, M., Naccarato, M., Contaldo, F., Poggiogalle, E., & Pasanisi, F. (2017). Evaluation of hypocaloric diet with protein supplementation in middle -aged sarcopenic obese women: a pilot study. Obes. Facts, 10(3), 160-167. https://doi.org/10.1159/000468153 
  20. Yin, Y. H., Liu J. Y., & Valimaki, M. (2023). Dietary behaviour change intervention for managing sarcopenic obesity among community -dwelling older people: a pilot randomised controlled trial. BMC Geriatrics, 23, 597. https://doi.org/10.1186/s12877-023-04327-w 
  21. Kemmler, W., Teschler, M., Weissenfels, A., Bebenek, M., Stengel, S., Kohl, M., & Engelke, K. (2016). Whole-body electromyostimulation to fight sarcopenic obesity in community -dwelling older women at risk. Results of the randomized controlled FORMOsA-sarcopenic obesity study. Osteoporos. Int, 27(11), 3261-3270. https://doi.org/10.1007/s00198-016-3662-z 
  22. Kemmler, W., Weissenfels, A., Teschler, M., Willert, S., Bebenek, M., Shojaa, M., & vonStengel, S. (2017). Whole-body electromyostimulation and protein supplementation favorably affect sarcopenic obesity in community-dwelling older men at risk: the randomized controlled FranSO study. (ORIGINAL RESEARCH) (Report). Clin Interv Aging, 12, 1503. https://doi.org/10.2147/CIA.S137987 
  23. Kim, H., Kim, M., Kojima, N., Fujino, K., Hosoi, E., Kobayashi, H., & Yoshida, H. (2016). Exercise and nutritional supplementation on community-dwelling elderly Japanese women with sarcopenic obesity: a randomized controlled trial. J Am Med Dir Assoc, 17 (11), 1011-1019. https://doi.org/10.1016/j.jamda.2016.06.016 
  24. Nabuco, H. C., Tomeleri, C. M., Fernandes, R. R., Junior, P. S., Cavalcante, E. F., Cunha, P. M., & Barbosa, D. S. (2019). Effect of whey protein supplementation combined with resistance training on body composition, muscular strength, functional capacity, and plasma-metabolism biomarkers in older women with sarcopenic obesity: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition ESPEN, 32, 88-95. https://doi.org/10.1016/j.clnesp.2019.04.007 
  25. Zhou, X., Xing, B., He, G., Lyu, X., & Zeng, Y. (2018). The effects of electrical acupuncture and essential amino acid supplementation on sarcopenic obesity in male older adults: a randomized control study. Obes. Facts. 11(4), 327-334. https://doi.org/10.1159/000491797 
  26. Cruz-Jentoft, A. J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T., Landi, F., ... & Zamboni, M.; European Working Group on Sarcopenia in Older People. (2010). Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing, 39, 412-423. https://doi.org/10.1093/ageing/afq034 
  27. Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., ... & Harris, T. B.; Health ABC Study Inverstigators. (2003). Sarcopenia: alternative definitions and associations with lower extremity function. Journal of the American Geriatrics Society, 51, 1602-1609. https://doi.org/10.1046/j.1532-5415.2003.51534.x 
  28. Chung, J. Y., Kang, H. T., Lee, D. C., Lee, H. R., & Lee, Y. J. (2013). Body composition and its association with cardiometabolic risk factors in the elderly: A focus on sarcopenic obesity. Arch Gerontol Geriatr, 56, 270-278. https://doi.org/10.1016/j.archger.2012.09.007 
  29. Lim, S., Kim, J. H., Yonn, J. W., kang, S. M., Choi, S. H., Park, Y. J., ... & Jang, H. C. (2010). Sarcopenic obesity: Prevalence and association with metabolic syndrome in the Korean longitudinal study on health and aging(klosha). Diabetes Care, 33, 1652-1654. https://doi.org/10.2337/dc10-0107 
  30. Janssen, I., Heymsfield, S. B., & Ross, R. (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc, 50, 889-896. https://doi.org/10.1046/j.1532-5415.2002.50216.x 
  31. Chen, L. K., Woo, J., Assantachai, P., Auyeung, T. W., Chou, M. Y., Iijima, K., ... & Arai, H. (2020). Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 21, 300-307.e2. https://doi.org/10.1016/j.jamda.2019.12.012 
  32. Studenski, S. A., Peters, K. W., Alley, D. E., Cawthon, P. M., McLean, R. R., Harris, T. B., ... & Vassileva, M. T. (2014). The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci, 69, 547-558. https://doi.org/10.1093/gerona/glu010 
  33. Chen, L. K., Liu, L. K., Woo, J., Assantachai, P., Auyeung, T. W., Bahyah, K. S., ... & Arai, H. (2014). Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 15, 95-101. https://doi.org/10.1016/j.jamda.2013.11.025 
  34. Ling, C. H., de Craen, A. J., Slagboom, P. E., Gunn, D.A., Stokkel, M.P., Westendorp, R.G., & Maier, A. B. (2011). Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. Clin Nutr, 30, 610-615. https://doi.org/10.1016/j.clnu.2011.04.001 
  35. Ji Yeon Baek, J. Y., Jung, H. W., Kim, K. M., Kim, M., Park Y. C., Lee, K. P., ... & Lim, J. Y. (2023). Korean Working Group on Sarcopenia Guideline: Expert Consensus on Sarcopenia Screening and Diagnosis by the Korean Society of Sarcopenia, the Korean Society for Bone and Mineral Research, and the Korean Geriatrics Society, Ann Geriatr Med Res, 27(1), 9-21. https://doi.org/10.4235/agmr.23.0009 
  36. Kim, K. K., Haam, J. H., Kim, B. T., Kim, E. M., Park, J. H., Rhee, S. Y., ... & Lee, C. B.; Committee of Clinical Parctice guidelines, Korean Society for the Study of Obestiy (KSSO). (2023). Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity. J Obes Metab Syndr, 32(1), 1-24. https://doi.org/10.7570/jomes23016 
  37. Ryan, D. H., & Yockey, S. R. (2017). Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over. Curr Obes Rep, 6, 187-194. https://doi.org/10.1007/s13679-017-0262-y 
  38. Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I. M., ... & Swain, D. P.; American College of Sports Medicine. (2011). American college of sports medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise. Med Sci Sports Exerc, 43, 1334-1359. https://doi.org/10.1249/MSS.0b013e318213fefb 
  39. Schulte, J. N., & Yarasheski, K. E. (2001). Effects of resistance training on the rate of muscle protein synthesis in frail elderly people. Int J Sport Nutr Exerc Metab, 11(Suppl), S111-118. https://doi.org/10.1123/ijsnem.11.s1.s111 
  40. Fry, A. C. (2004). The role of resistance exercise intensity on muscle fibre adaptations. Sports Med, 34, 663-79. https://doi.org/10.2165/00007256-200434100-00004 
  41. Hunter, G. R., Wetztein, C. J., Mclafferty, C. L. Jr., Zuckerman, P. A., Landers, K. A., & Bamman, M. M. (2001). High-resistance versus variable-resistance training in older adults. Med Sci Sports Exerc, 33, 1759-1764. https://doi.org/10.1097/00005768-200110000-00022 
  42. Guang, J. W., Hossein, A. M., & Wei, B. Z. (2010). Meridian studies in China: a systematic review. J Acupunct Meridian Stud, 3, 1-9. https://doi.org/10.1016/S2005-2901(10)60001-5 
  43. Cho, J. K., Kang, H. S., & Yoon, J. H. (2013). Increased Dietary intake of proteins for the prevention and Treatment of sarcopenic obesity in the Elderly. Korean J obes, 22, 77-82. https://doi.org/10.7570/kjo.2013.22.2.77 
  44. Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., ... & Phillips, S. M. (2017). A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med, 52(6), 376-384. https://doi.org/10.1136/bjsports-2017-097608 
  45. Sandberg, M., Lundeberg, T., Lindberg, L. G., & Gerdle, B. (2003). Effects of acupuncture on skin and muscle blood flow in healthy subjects. Eur J Appl Physiol, 90, 114-119. https://doi.org/10.1007/s00421-003-0825-3 
  46. Shinbara, H., Okubo, M., Kimura, K., Mizunuma, K., & Sumiya, E. (2015). Contributions of nitric oxide and prostaglandins to the local increase in muscle blood flow following manual acupuncture in rats. Acupunct Med, 33, 65-71. https://doi.org/10.1136/acupmed-2014-010634 
  47. Zamboni, M., Mazzali, G., Zoico, E., Harris, T. B., Meigs, J. B., Di Francesco, V., ... & Bosello, O. (2005). Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond), 29(9), 1011-1029. https://doi.org/10.1038/sj.ijo.0803005