DOI QR코드

DOI QR Code

뇌졸중 환자에 대한 레이저 치료의 효과: 체계적 문헌고찰 및 메타분석

The Effect of Laser Therapy for Stroke Patients : A Systematic Review and Meta-analysis

  • 안다영 (상지대학교 한의과대학 내과학교실) ;
  • 선승호 (상지대학교 한의과대학 내과학교실)
  • Da-young An (Department of Internal Korean Medicine, College of Korean Medicine, Sangji University) ;
  • Seung-ho Sun (Department of Internal Korean Medicine, College of Korean Medicine, Sangji University)
  • 투고 : 2023.11.17
  • 심사 : 2024.02.16
  • 발행 : 2024.03.01

초록

Objectives: This study is purposed to investigate the effect and safety of laser therapy for stroke patients by systematic review and meta-analysis of the randomized controlled trials (RCTs). Methods: RCTs on the treatment of laser therapy for stroke patients were selected among the literature published from January 2000 to June 2022 in twelve domestic and foreign databases. The quality of the literature was evaluated using the Cochrane's Risk of Bias tool and RevMan 5.4 was used for the synthesis of results. Results: Total 2,598 patients with stroke were finally selected from 18 RCTs. Meta-analysis showed that laser therapy was effective in significantly improving activities of daily living (MBI), motor function (effective rate), upper motor function (FMA-UE), shoulder pain related factors (CGRP, ET-1, BK). Overall, the risk of bias was uncertain or low in the quality assessment of the literature. Conclusions: Although it is unclear that laser therapy is more effective than sham laser, laser therapy might be more effective in improving symptoms than conventional rehabilitation alone. Furthermore, no serious adverse events were founded in laser therapy studies. However, the quality of the selected literature was generally low. Therefore, further studies with high methodological quality on laser therapy for stroke patients would be required in the future.

키워드

참고문헌

  1. Korean stroke society. Textbook of stroke. 2nd ed. Seoul: PanMun education. 2015, p. 3, 57-63, 389, 527, 550. 
  2. Mercier L, Audet T, Hebert R, Rochette A, Dubois M-F. Impact of motor, cognitive, and perceptual disorders on ability to perform activities of daily living after stroke. Stroke. 2001; 32(11):2602-8. http://doi.org/10.1161/hs1101.098154 
  3. Hong KS, Bang OY, Kang DW, Yu KH, Bae HJ, Lee JS, et al. Stroke statistics in Korea: part I. Epidemiology and risk factors: a report from the korean stroke society and clinical research center for stroke. J Stroke. 2013;15(1):2-20. http://doi.org/10.5853/jos.2013.15.1.2 
  4. Opara JA, Jaracz K. Quality of life of post-stroke patients and their caregivers. J Med Life. 2010;3(3):216-20. Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018998/ 
  5. Lee KG, Shin JH, Lee KJ, Sun SH, Jang IS. Review on Laser or LED Therapy for the Photobiomodulation of Diseases of the Cerebral Nervous System. J. Int. Korean Med. 2014:35(4)546-55. Available from https://www.jikm.or.kr/journal/view.php?number=1777 
  6. Kim HH, Nam DW, Lee SH. Fundamentals and Research Trend of Laser Acupuncture. J Korean Acupunct Moxib Soc. 2009;26(6):21-30. Available from https://koreascience.kr/article/JAKO200921147395853.page 
  7. Tuner J, Hode L. Laser Therapy. Seoul: JeongDam. 2011, p. 8-9, 104-7. 
  8. Han HJ, Kang KW, Kang SY, Kim LH, Jang IS. The Clinical Indication of Low-Level Laser Therapy Using ICD-10. J Int Korean Med. 2018;36(4):561-9. Available from https://www.jikm.or.kr/m/journal/view.php?number=1881 
  9. Howard BC, Roberta TC, Michael RH, James C. The Use of Low Level Laser Therapy(LLLT) For Musculoskeletal Pain. MOJ Orthop Rheumatol. 2015;2(5):00068. http://doi.org/10.15406/mojor.2015.02.00068 
  10. Moskvin SV, Khadartsev AA. Methods of effective low-level laser therapy in the treatment of patients with bronchial asthma (literature review). Biomedicine(Taipei). 2020;10(1):1-20. http://doi.org/10.37796/2211-8039.1000 
  11. Gottschling S, Meyer S, Gribova I, Distler L, Berrang J, Gortner L, et al. Laser acupuncture in children with headache : A double-blind, randomized, bicenter, placebocontrolled trial. Pain. 2008;137:405-12. http://doi.org/10.1016/j.pain.2007.10.004 
  12. Yi WJ, Zhang L, Wang ZZ,Chu XH,Chen J. Research progress of laser therapy in rehabilitation of stroke patients. LASER JOURNAL. 2021(9);42(9):198-201. 
  13. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Ver 5.1.0 [updated Mar 2011]. The Cochrane Collaboration. 2011. Available from http://handbook.cochrane.org 
  14. Higgins JPT, Green S. Analyzing and presenting results. Cochrane handbook for systematic reviews of interventions 4.2.6. Chichester, UK: John Wiley&Sons Inc. 2008:79-165. 
  15. Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH, Son HJ, et al. NECA's guidance for undertaking systematic reviews and meta-analyses for intervention. National Evidence-based Healthcare Collaborating Agency; 2011. [in Korean]. 
  16. Lampl Y, Zivin J, Fisher M, Lew R, Welin L, Dahlof B, et al. Infrared laser therapy for ischemic stroke: a new treatment strategy. Results of the NeuroThera effectiveness and safety trial-1(NEST-1). Stroke. 2007;38:1843-9. http://doi.org/10.1161/STROKEAHA.106.478230 
  17. Zivin J, Albers G, Bornstein N, Chippendale T, Dahlof B, Devlin T, et al. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009;40(4):1359-64. http://doi.org/10.1161/STROKEAHA.109.547547 
  18. Hacke W, Schellinger PD, Albers GW, Bornstein NM, Dahlof BL, Fulton R, et al. Transcranial Laser Therapy in Acute Stroke Treatment results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial. Stroke. 2014;45(11):3187-93. http://doi.org/10.1161/STROKEAHA.114.005795 
  19. Jiang GF, Zong LQ, Yin YJ, Xuan ZW. Effects of Laser therapy on Dysphagia after Acute Stroke(激光血疗对急性脑卒中后吞咽功能障碍的疗效评价). Modern Rehabilitation. 2001;5(9):62. 
  20. Luo YW, Luo WH, Hwang BY. Analysis of the Results of Exercise Function after Stroke by Laser Therapy(超激光疼痛治疗仪对脑卒中后运动功能干预结果分析). Modern Rehabilitation. 2001;5(2):88. http://doi.org/10.3321/j.issn:1673-8225.2001.02.069 
  21. Pan CH, Pu SX. Effects of Early Intravascular Laser Blood Irradiation and Rehabilitation on Motor Function of Upper and Lower Extremities and Activities of Daily Living in the Patients with Acute Stroke. Chinese Journal of Rehabilitation. 2003;18(6):363-4. 
  22. Liu QS, Wu JX, Liu HL, Li Hong. Effects of He-Ne laser intravascular irradiation on hemorheology and blood lipid of acute cerebral infarction patients. Chinese Journal of Clinical Rehabilitation. 2005;9(1):66-9. 
  23. Azra K, Suada KD, Farid L. Laser therapy of painful shoulder and shoulder-hand syndrome in treatment of patients after the stroke. Bosn J Basic Med Sci. 2009;9(1):59-65. http://doi.org/10.17305/bjbms.2009.2858 
  24. Feng YM, Cheng ZP, Sun H, Shi D. Laser acupuncture treatment in stroke patients with hemiplegia Applications. LASER JOURNAL. 2013;34(6):70-1. 
  25. Hu YL, Xiao YH, Liu AM, Hua YP, Huang Y. Effectiveness of Low Level Laser Combined with Shoulder Control Training in the Treatment of Shoulder Pain in Elderly Hemiplegic Patients with Cerebral Hemiplegia (低强度激光结合肩部控制训练治疗老年脑卒中偏瘫病人肩痛的疗效观察). Practical Geriatrics. 2017;31(2):175-7. 
  26. Jan F, Naeem A, Malik AN, Amjad I, Malik T. Comparison of low level laser therapy and interferential current on post stroke shoulder pain. J Pak Med Assoc. 2017;67(5):788-9. 
  27. Yu HX, Yang CS, Jia J, He L, Wu GY, Zhang R, et al. Effects of laser radiation at acupoint and hand projection areas of brain on hand and upper extremity function of early stroke patients. Chinese Journal of Reha⁃bilitation Medicine. 2018;33(3):315-8. http://doi.org/10.3969/j.issn.1001-1242.2018.03.012 
  28. Sun L, Shen XY, Ye W, Yan S. Curative effectiveness of laser irradiation in nasal cavity for patients with cognitive impairment after stroke. Chinese Journal of Rehabilitation. 2018;33(4):272-4. http://doi.org/10.3870/zgkf.2018.04.002 
  29. Zhang NJ, Jin XS, Ji PP. Curative Effect of High Intensity Laser Therapy Combined with Upper Limb Intelligent Feedback Training System on Patients with Complex Regional Pain Syndrome Type I in after Ischemic Stroke. Journal of practical cardiocerebral pulmonary vasculopathy. 2020;28(7):120-4. http://doi.org/10.3969/j.issn.1008-5971.2020.07.022 
  30. Zhao XK, Zhou JJ, Zhang QQ. Efficacy of high-energy laser in the treatment of early stroke patients with shoulder-hand syndrome. Acta Medicinae Sinica. 2021;34(4)132-6. http://doi.org/10.19296/j.cnki.1008-2409.2021-04-034 
  31. Qi L, Zhen QX, Liu C, Yan HJ, Liu AX. Effect of semiconductor laser acupoint irradiation combined with intelligent rehabilitation robot on stroke hemiplegia and BBS and FMA scores. Journal of Clinical and Experimental Medicine. 2022;21(5)539-42. http://doi.org/10.3969/j.issn.1671-4695.2022.05.025 
  32. He BJ, Xia HT, Liang JQ, Zeng DY, Liang YC, Wang ZQ. Evaluation of the effect of super laser irradiation on stellate ganglion combined with pregabalin in the treatment of central neuralgia after stroke. Journal of China Prescription Drug. 2022;20(3):110-2. http://doi.org/10.3969/j.issn.1671-945X.2022.03.044 
  33. Korkmaz N, Gurcay E, Demir Y, Tezen O, Korkmaz I, Atar M O, et al. The effectiveness of high-intensity laser therapy in the treatment of post-stroke patients with hemiplegic shoulder pain: a prospective randomized controlled study. Lasers Med Sci. 2022;37(1):645-53. http://doi.org/10.1007/s10103-021-03316-y 
  34. Park SU, Cho SY, Park JM, Ko CN, Park HJ, Walls B, et al. Integrative treatment modalities for stroke victims in Korea. Complementary Therapies in Clinical Practice. 2014;20(1):37-41. http://doi.org/10.1016/j.ctcp.2013.10.007 
  35. Yamashita H, Tsukayama H, Tanno Y, Nishijo K. Adverse events in acupuncture and moxibustion treatment: a six-year survey at a national clinic in Japan. J Altern Complement Med. 1999 Jun;5(3):229-36. http://doi.org/10.1089/acm.1999.5.229 
  36. Siedentopf CM, Koppelstaetter F, Haala IA, Haid V, Rhomberg P, Ischebeck A, et al. Laser acupuncture induced specific cerebral cortical and subcortical activations in humans. Lasers Med Sci. 2005;20(2):68-73. http://doi.org/10.1007/s10103-005-0340-3 
  37. Lv J, Shi CH, Deng YJ, Lou WT, Hu j, Shi L, et al. The brain effects of laser acupuncture at thirteen ghost acupoints in healthy individuals: A resting-state functional MRI investigation. Computerized Medical Imaging and Graphics. 2016(12);54:48-54. http://doi.org/10.1016/j.compmedimag.2016.08.003