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A Case Study on the Effectiveness of tDCS to Reduce Cyber-Sickness in Subjects with Dizziness

  • Chang Ju Kim (Department of Physical Therapy, College of Health Science, Cheongju University) ;
  • Yoon Tae Hwang (Department of Physical Therapy, Gangneung Yeongdong University) ;
  • Yu Min Ko (Department of Physical Therapy, Gangneung Yeongdong University) ;
  • Seong Ho Yun (Department of Health, Graduate School, Dankook University) ;
  • Sang Seok Yeo (Department of Physical Therapy, College of Health Sciences, Dankook University)
  • 투고 : 2024.02.08
  • 심사 : 2024.02.27
  • 발행 : 2024.02.28

초록

Purpose: Cybersickness is a type of motion sickness induced by virtual reality (VR) or augmented reality (AR) environments that presents symptoms including nausea, dizziness, and headaches. This study aimed to investigate how cathodal transcranial direct current stimulation (tDCS) alleviates motion sickness symptoms and modulates brain activity in individuals experiencing cybersickness after exposure to a VR environment. Methods: This study was performed on two groups of healthy adults with cybersickness symptoms. Subjects were randomly assigned to receive either cathodal tDCS intervention or sham tDCS intervention. Brain activity during VR stimulation was measured by 38-channel functional near-infrared spectroscopy (fNIRS). tDCS was administered to the right temporoparietal junction (TPJ) for 20 minutes at an intensity of 2mA, and the severity of cybersickness was assessed pre- and post-intervention using a simulator sickness questionnaire (SSQ). Result: Following the experiment, cybersickness symptoms in subjects who received cathodal tDCS intervention were reduced based on SSQ scores, whereas those who received sham tDCS showed no significant change. fNIRS analysis revealed that tDCS significantly diminished cortical activity in subjects with high activity in temporal and parietal lobes, whereas high cortical activity was maintained in these regions after intervention in subjects who received sham tDCS. Conclusion: These findings suggest that cathodal tDCS applied to the right TPJ region in young adults experiencing cybersickness effectively reduces motion sickness induced by VR environments.

키워드

과제정보

본 연구는 한국정부가 지원하는 한국연구재단의 연구비 지원을 받은 연구임(2021R1G1A1095407).

참고문헌

  1. Keshavarz B, Golding JF. Motion sickness: current concepts and management. Curr Opin Neurol. 2022;35(1):107-12. 
  2. Mittelstaedt JM. Individual predictors of the susceptibility for motion-related sickness: a systematic review. J Vestib Research. 2020;30(3):165-93. 
  3. Fabre M, Beullier L, Sutter C et al. Cortical facilitation of somatosensory inputs using gravity-related tactile information in humans with vestibular hypofunction. J Neurophysiol. 2023;130(1):155-67. 
  4. Wibble T, Pansell T. Clinical characteristics of visual motion hypersensitivity: a systematic review. Exp Brain Res. 2023;241:1-13. 
  5. Buchheit B, Schneider E, Alayan M et al. Motion sickness related route profiling for evaluation of the sensory conflict in real-driving studies. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). 2022:816-9. 
  6. Chung W, Barnett-Cowan M. Influence of sensory conflict on perceived timing of passive rotation in virtual reality. Multisensory Res. 2022;35(5):367-89. 
  7. Drazich BF, McPherson R, Gorman EF et al. In too deep? A systematic literature review of fully-immersive virtual reality and cybersickness among older adults. J Am Geriatr Soc. 2023;71(12):3906-15. 
  8. Weech S, Kenny S, Barnett-Cowan M. Presence and cybersickness in virtual reality are negatively related: a review. Front Psychol. 2019;10:158. 
  9. Lundin RM, Yeap Y, Menkes DB. Adverse effects of virtual and augmented reality interventions in psychiatry: systematic review. JMIR Mental Health. 2023;10:e43240. 
  10. Yeo SS, Kwon JW, Park SY. EEG-based analysis of various sensory stimulation effects to reduce visually induced motion sickness in virtual reality. Sci Rep. 2022;12(1):18043. 
  11. Ang S, Quarles J. Reduction of cybersickness in head mounted displays use: a systematic review and taxonomy of current strategies. Front Virtual Real. 2023;4:1027552. 
  12. Chang E, Billinghurst M, Yoo B. Brain activity during cybersickness: a scoping review. Virtual Real. 2023;27:2073-97. 
  13. Park WD, Jang SW, Kim YH et al. A study on cyber sickness reduction by oculo-motor exercise performed immediately prior to viewing virtual reality (VR) content on head mounted display (HMD). Vib Proced. 2017;14:260-4. 
  14. Benelli A, Neri F, Cinti A et al. Frequency-dependent reduction of cybersickness in virtual reality by transcranial oscillatory stimulation of the vestibular cortex. Neurotherapeutics. 2023;20(6):1796-807. 
  15. Huang W, Wang H, Hu N et al. Efficacy of noninvasive brain stimulation in treating general psychopathology symptoms in schizophrenia: a meta-analysis. J Integr Neurosci. 2024;23(1):7. 
  16. Bormann NL, Oesterle TS, Arndt S et al. Systematic review and meta-analysis: combining transcranial magnetic stimulation or direct current stimulation with pharmacotherapy for treatment of substance use disorders. Am J Addict. 2024. 
  17. Halakoo S, Ehsani F, Hosnian M et al. The comparative effects of anodal and cathodal trans-cranial direct current stimulation on balance and posture: a systematic review of literature and meta-analysis. J Clin Neurosci. 2023;107:68-76. 
  18. Kennedy RS, Lane NE, Berbaum KS et al. Simulator sickness questionnaire: an enhanced method for quantifying simulator sickness. Int J Aviat Psychol. 1993;3(3):203-20. 
  19. Frank SM, Greenlee MW. The parieto-insular vestibular cortex in humans: more than a single area? J neurophysiol. 2018;120(3):1438-50. 
  20. Zhang D, Zhou Y, Yuan J. Speech prosodies of different emotional categories activate different brain regions in adult cortex: an fNIRS study. Scientific Reports. 2018;8(1):218. 
  21. Baker WB, Parthasarathy AB, Busch DR et al. Modified beer-lambert law for blood flow. Biomed Opt Express. 2014;5(11):4053-75. 
  22. Takeuchi N, Mori T, Suzukamo Y et al. Modulation of excitability in the temporoparietal junction relieves virtual reality sickness. Cyberpsychol Behav Soc Netw. 2018;21(6):381-7. 
  23. Kyriakareli A, Cousins S, Pettorossi VE et al. Effect of transcranial direct current stimulation on vestibular-ocular and vestibulo-perceptual thresholds. Neuroreport. 2013;24(14):808-12. 
  24. Koganemaru S, Goto F, Arai M et al. Effects of vestibular rehabilitation combined with transcranial cerebellar direct current stimulation in patients with chronic dizziness: an exploratory study. Brain Stimulation. 2017;10(3):576-8. 
  25. Nguyen NT, Takakura H, Nishijo H et al. Cerebral hemodynamic responses to the sensory conflict between visual and rotary vestibular stimuli: an analysis with a multichannel near-infrared spectroscopy (NIRS) system. Front Hum Neurosci. 2020;14:125.