Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of prior cesarean delivery on the outcomes of intracytoplasmic sperm injection

  • Received : 2023.05.17
  • Accepted : 2023.08.28
  • Published : 2024.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer. Methods: This prospective observational study included 140 patients experiencing secondary infertility. Of these, 70 patients had a previous cesarean delivery (CD), while the remaining 70 patients had a previous normal vaginal delivery (NVD). The primary outcome was the implantation rate. The secondary outcomes included rates of clinical pregnancy, chemical pregnancy, miscarriage, and ectopic pregnancy. Results: The comparison of all fertility outcomes between the two groups revealed no statistically significant differences. The implantation rate was 40.4% in the CD group and 41.7% in the NVD group (p=0.842). The clinical pregnancy rate was 50% in the CD group and 49.3% in the NVD group (p=0.932), while the chemical pregnancy rate was 14.6% in the CD group and 19% in the NVD group (p=0.591). The miscarriage rates in the CD and NVD groups were 20% and 17.6%, respectively (p=0.803). One case of tubal ectopic pregnancy occurred in the NVD group (1.4%). Conclusion: The mode of prior delivery did not significantly impact pregnancy outcomes following frozen-thawed embryo transfer.

Keywords

Acknowledgement

The authors wish to extend their gratitude to the staff and embryologists at the intracytoplasmic sperm injection center at which the study took place, for their assistance in data collection.

References

  1. Betran AP, Ye J, Moller AB, Souza JP, Zhang J. Trends and projections of caesarean section rates: global and regional estimates. BMJ Glob Health 2021;6:e005671. 
  2. D'Antonio F, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteagudo A, Buca D, Forlani F, et al. First-trimester detection of abnormally invasive placenta in high-risk women: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018;51:176-83. 
  3. O'Neill SM, Kearney PM, Kenny LC, Henriksen TB, Lutomski JE, Greene RA, et al. Caesarean delivery and subsequent pregnancy interval: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2013;13:165. 
  4. Tollanes MC, Melve KK, Irgens LM, Skjaerven R. Reduced fertility after cesarean delivery: a maternal choice. Obstet Gynecol 2007;110:1256-63. 
  5. Murphy DJ, Stirrat GM, Heron J; ALSPAC Study Team. The relationship between caesarean section and subfertility in a population-based sample of 14 541 pregnancies. Hum Reprod 2002;17:1914-7. 
  6. Vissers J, Hehenkamp W, Lambalk CB, Huirne JA. Post-caesarean section niche-related impaired fertility: hypothetical mechanisms. Hum Reprod 2020;35:1484-94. 
  7. Zhao J, Hao J, Xu B, Wang Y, Li Y. Impact of previous caesarean section on reproductive outcomes after assisted reproductive technology: systematic review and meta-analyses. Reprod Biomed Online 2021;43:197-204. 
  8. Diao J, Gao G, Zhang Y, Wang X, Zhang Y, Han Y, et al. Caesarean section defects may affect pregnancy outcomes after in vitro fertilization-embryo transfer: a retrospective study. BMC Pregnancy Childbirth 2021;21:487. 
  9. Patounakis G, Ozcan MC, Chason RJ, Norian JM, Payson M, DeCherney AH, et al. Impact of a prior cesarean delivery on embryo transfer: a prospective study. Fertil Steril 2016;106:311-6. 
  10. Zhang N, Chen H, Xu Z, Wang B, Sun H, Hu Y. Pregnancy, delivery, and neonatal outcomes of in vitro fertilization-embryo transfer in patient with previous cesarean scar. Med Sci Monit 2016;22:3288-95. 
  11. Riemma G, De Franciscis P, Torella M, Narciso G, La Verde M, Morlando M, et al. Reproductive and pregnancy outcomes following embryo transfer in women with previous cesarean section: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2021;100:1949-60. 
  12. Wang L, Yao W, Tang X, Yao H, Wei S, Huang J, et al. Fertility outcomes of IVF/ICSI after caesarean section: a cohort study. Reprod Biomed Online 2020;40:719-28. 
  13. van den Tweel MM, Klijn NF, Diaz de Pool JDN, van der Westerlaken LAJ, Louwe LA. Previous caesarean section is associated with lower subsequent in vitro fertilization live birth rates. Hum Fertil (Camb) 2022;25:93-8. 
  14. Grimes DA, Schulz KF. Determining sample size and power in clinical trials: the forgotten essential. Semin Reprod Endocrinol 1996;14:125-31. 
  15. Ciray HN, Aksoy T, Yaramanci K, Karayaka I, Bahceci M. In vitro culture under physiologic oxygen concentration improves blastocyst yield and quality: a prospective randomized survey on sibling oocytes. Fertil Steril 2009;91(4 Suppl):1459-61. 
  16. Kotz S, Read CB, Balakrishnan N, Vidakovic B, Johnson NL. Encyclopedia of statistical sciences. Wily; 2006. 
  17. Kirkpatrick LA, Feeney BC. A simple guide to IBM SPSS statistics: version 23.0. 14th ed. Cengage Learning; 2015. 
  18. Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, et al. Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts. Hum Reprod 2014;29:1173-81. 
  19. Ye J, Zhang J, Mikolajczyk R, Torloni MR, Gulmezoglu AM, Betran AP. Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. BJOG 2016;123:745-53. 
  20. Hinterleitner L, Kiss H, Ott J. The impact of cesarean section on female fertility: a narrative review. Clin Exp Obstet Gynecol 2021;48:781-6. 
  21. Gurol-Urganci I, Bou-Antoun S, Lim CP, Cromwell DA, Mahmood TA, Templeton A, et al. Impact of caesarean section on subsequent fertility: a systematic review and meta-analysis. Hum Reprod 2013;28:1943-52. 
  22. Kjerulff KH, Paul IM, Weisman CS, Hillemeier MM, Wang M, Legro RS, et al. Association between mode of first delivery and subsequent fecundity and fertility. JAMA Netw Open 2020;3:e203076. 
  23. Bayram A, Elkhatib I, Abdala A, Nogueira D, Melado L, Fatemi HM, et al. ART outcome after euploid frozen embryo transfer is not affected by previous cesarean section delivery in the absence of intracavitary fluid. J Assist Reprod Genet 2022;39:2529-37. 
  24. Ben-Nagi J, Walker A, Jurkovic D, Yazbek J, Aplin JD. Effect of cesarean delivery on the endometrium. Int J Gynaecol Obstet 2009;106:30-4. 
  25. Huang J, Lin J, Cai R, Lu X, Song N, Gao H, et al. Effect of a prior cesarean delivery on pregnancy outcomes of frozen-thawed embryo transfer: a retrospective cohort study in a freeze-all setting. Acta Obstet Gynecol Scand 2020;99:1303-10. 
  26. Cai M, Pan X, Xia W, Liang X, Yang X. Intra-cavitary fluid resulted from caesarean section but not isthmocele compromised clinical pregnancy after IVF/ICSI treatment. Arch Gynecol Obstet 2022;306:229-37. 
  27. Yang XJ, Sun SS. Comparison of maternal and fetal complications in elective and emergency cesarean section: a systematic review and meta-analysis. Arch Gynecol Obstet 2017;296:503-12.