Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The relationship between anthropometric and metabolic risk factors and testicular function in healthy young men

  • Hakki Uzun (Department of Urology, Recep Tayyip Erdogan University School of Medicine) ;
  • Merve Huner (Department of Biochemistry, Recep Tayyip Erdogan University School of Medicine) ;
  • Mehmet Kivrak (Department of Biostatistics, Recep Tayyip Erdogan University School of Medicine) ;
  • Ertan Zengin (Department of Radiology, Recep Tayyip Erdogan University School of Medicine) ;
  • Yusuf Onder Ozsagir (Department of Urology, Recep Tayyip Erdogan University School of Medicine) ;
  • Berat Sonmez (Department of Urology, Recep Tayyip Erdogan University School of Medicine) ;
  • Gorkem Akca (Department of Urology, Recep Tayyip Erdogan University School of Medicine)
  • Received : 2023.05.09
  • Accepted : 2023.08.07
  • Published : 2024.03.31
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Abstract

Objective: This study investigated the relationship of anthropometric and metabolic risk factors with seminal and sex steroidal hormone parameters in a screened population of healthy males. Methods: The participants were healthy young men without chronic or congenital diseases. The body composition parameters that we investigated were measured weight, height, and waist circumference (WC), as well as bioelectrical impedance analysis. Semen samples were analyzed for semen volume, sperm concentration, sperm motility and morphology, seminal pH, and liquefaction time. Biochemistry analysis, including glucose and lipid metabolism parameters, was conducted on fasting blood samples. Testicular volume was calculated separately for each testis using ultrasonography. Results: Body mass index exhibited an inverse association with total sperm count. WC showed negative correlations with numerous seminal parameters, including sperm concentration, total sperm count, sperm morphology, and follicle-stimulating hormone levels. The basal metabolic rate was associated with seminal pH, liquefaction time, and sperm motility. WC, fat mass percentage, and triglyceride levels exhibited negative correlations with sex hormone binding globulin. The measures of glucose metabolism were associated with a greater number of seminal parameters than the measures of cholesterol metabolism. C-reactive protein levels were inversely associated with sperm concentration and total sperm count. Conclusion: Anthropometric and metabolic risk factors were found to predict semen quality and alterations in sex steroidal hormone levels.

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References

  1. Levine H, Jorgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update 2017;23:646-59. 
  2. Li CJ, Tzeng CR, Chen RY, Han BC, Yeh CY, Chien LC. Decline in semen quality in men in northern Taiwan between 2001 and 2010. Chin J Physiol 2016;59:355-65. 
  3. Sengupta P, Nwagha U, Dutta S, Krajewska-Kulak E, Izuka E. Evidence for decreasing sperm count in African population from 1965 to 2015. Afr Health Sci 2017;17:418-27. 
  4. Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E. Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol 2018;37:247-55. 
  5. Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, et al. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 2016;96:55-97. 
  6. Eisenberg ML, Li S, Cullen MR, Baker LC. Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data. Fertil Steril 2016;105:629-36. 
  7. Latif T, Kold Jensen T, Mehlsen J, Holmboe SA, Brinth L, Pors K, et al. Semen quality as a predictor of subsequent morbidity: a Danish cohort study of 4,712 men with long-term follow-up. Am J Epidemiol 2017;186:910-7. 
  8. Eisenberg ML, Li S, Behr B, Cullen MR, Galusha D, Lamb DJ, et al. Semen quality, infertility and mortality in the USA. Hum Reprod 2014;29:1567-74. 
  9. Jensen TK, Jacobsen R, Christensen K, Nielsen NC, Bostofte E. Good semen quality and life expectancy: a cohort study of 43,277 men. Am J Epidemiol 2009;170:559-65. 
  10. Walsh TJ, Schembri M, Turek PJ, Chan JM, Carroll PR, Smith JF, et al. Increased risk of high-grade prostate cancer among infertile men. Cancer 2010;116:2140-7. 
  11. Hart RJ, Doherty DA, Mori TA, Adams LA, Huang RC, Minaee N, et al. Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age. Hum Reprod 2019;34:389-402. 
  12. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome: a new worldwide definition: a consensus statement from the International Diabetes Federation. Diabet Med 2006;23:469-80. 
  13. Ferlin A, Garolla A, Ghezzi M, Selice R, Palego P, Caretta N, et al. Sperm count and hypogonadism as markers of general male health. Eur Urol Focus 2021;7:205-13. 
  14. Ventimiglia E, Capogrosso P, Colicchia M, Boeri L, Serino A, Castagna G, et al. Metabolic syndrome in white European men presenting for primary couple's infertility: investigation of the clinical and reproductive burden. Andrology 2016;4:944-51. 
  15. Rosenblatt F. Two theorems of statistical separability in the perceptron. United States Department of Commerce, Office of Technical Services; 1958.
  16. Ma J, Wu L, Zhou Y, Zhang H, Xiong C, Peng Z, et al. Association between BMI and semen quality: an observational study of 3966 sperm donors. Hum Reprod 2019;34:155-62. 
  17. Eisenberg ML, Kim S, Chen Z, Sundaram R, Schisterman EF, Louis GM. The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. Hum Reprod 2015;30:493-4. 
  18. Fejes I, Koloszar S, Szollosi J, Zavaczki Z, Pal A. Is semen quality affected by male body fat distribution? Andrologia 2005;37:155-9. 
  19. Hammiche F, Laven JS, Twigt JM, Boellaard WP, Steegers EA, Steegers-Theunissen RP. Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Hum Reprod 2012;27:2365-72. 
  20. Tsao CW, Liu CY, Chou YC, Cha TL, Chen SC, Hsu CY. Exploration of the association between obesity and semen quality in a 7630 male population. PLoS One 2015;10:e0119458. 
  21. Ehala-Aleksejev K, Punab M. The different surrogate measures of adiposity in relation to semen quality and serum reproductive hormone levels among Estonian fertile men. Andrology 2015;3:225-34.
  22. Wan CS, Ward LC, Halim J, Gow ML, Ho M, Briody JN, et al. Bioelectrical impedance analysis to estimate body composition, and change in adiposity, in overweight and obese adolescents: comparison with dual-energy X-ray absorptiometry. BMC Pediatr 2014;14:249. 
  23. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 2005;366:1640-9. 
  24. Gundmi S, Maiya AG, Bhat AK, Hande MH, Kumar AS. Screening for basal metabolic rate and visceral fat among postmenopausal osteoporosis with type 2 diabetes mellitus. Diabetes Metab Syndr 2019;13:981-4. 
  25. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, et al. Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab 1998;83:1886-92. 
  26. Vasquez-Alvarez S, Bustamante-Villagomez SK, Vazquez-Marroquin G, Porchia LM, Perez-Fuentes R, Torres-Rasgado E, et al. Metabolic age, an index based on basal metabolic rate, can predict individuals that are high risk of developing metabolic syndrome. High Blood Press Cardiovasc Prev 2021;28:263-70. 
  27. Manini TM. Energy expenditure and aging. Ageing Res Rev 2010;9:1-11. 
  28. Palmer NO, Bakos HW, Fullston T, Lane M. Impact of obesity on male fertility, sperm function and molecular composition. Spermatogenesis 2012;2:253-63. 
  29. Marchiani S, Vignozzi L, Filippi S, Gurrieri B, Comeglio P, Morelli A, et al. Metabolic syndrome-associated sperm alterations in an experimental rabbit model: relation with metabolic profile, testis and epididymis gene expression and effect of tamoxifen treatment. Mol Cell Endocrinol 2015;401:12-24. 
  30. Goldstajn MS, Toljan K, Grgic F, Jurkovic I, Baldani DP. Sex hormone binding globulin (SHBG) as a marker of clinical disorders. Coll Antropol 2016;40:211-8. 
  31. Hammoud AO, Gibson M, Peterson CM, Meikle AW, Carrell DT. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril 2008;90:897-904.
  32. Morgante G, Tosti C, Orvieto R, Musacchio MC, Piomboni P, De Leo V. Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome. Fertil Steril 2011;95:2150-2. 
  33. Liu CY, Chang TC, Lin SH, Wu ST, Cha TL, Tsao CW. Metformin ameliorates testicular function and spermatogenesis in male mice with high-fat and high-cholesterol diet-induced obesity. Nutrients 2020;12:1932. 
  34. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005;111:1448-54. 
  35. Bakos HW, Mitchell M, Setchell BP, Lane M. The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. Int J Androl 2011;34(5 Pt 1):402-10. 
  36. Leisegang K, Bouic PJ, Henkel RR. Metabolic syndrome is associated with increased seminal inflammatory cytokines and reproductive dysfunction in a case-controlled male cohort. Am J Reprod Immunol 2016;76:155-63. 
  37. Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, et al. One semen sample or 2?: insights from a study of fertile men. J Androl 2007;28:638-43.