Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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Inorganic Compound and Cycloserine Composite Particles for Improved Stability

안정성 개선을 위한 무기화합물과 사이클로세린 복합 입자

  • Dongwon Kim (Department of Pharmaceutical Engineering, Dankook University) ;
  • Heeseo Kim (Department of Pharmaceutical Engineering, Dankook University) ;
  • Hongjun Yoon (Department of Innovative Drug Discovery and Development, College of Pharmacy, Keimyung University) ;
  • Hyuk Jun Cho (Department of Innovative Drug Discovery and Development, College of Pharmacy, Keimyung University) ;
  • Sung Giu Jin (Department of Pharmaceutical Engineering, Dankook University)
  • 김동원 (단국대학교 제약공학과) ;
  • 김희서 (단국대학교 제약공학과) ;
  • 윤홍준 (계명대학교 혁신신약학과) ;
  • 조혁준 (계명대학교 혁신신약학과) ;
  • 진성규 (단국대학교 제약공학과)
  • Received : 2024.02.12
  • Accepted : 2024.04.20
  • Published : 2024.04.28
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Abstract

The aim of this study was to improve the chemical stability of cycloserine containing organic and inorganic compounds. Composite particles were manufactured with a 1:1 weight ratio of organic/inorganic compounds and cycloserine. The influence of organic/inorganic compounds on the stability of cycloserine was investigated under accelerated stress conditions at 60℃/75% RH for 24 hours. In addition, the properties of the composite particles were evaluated using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and the dissolution of the drug was assessed by preparing it as a hard capsule. Among the organic and inorganic compounds investigated, calcium hydroxide most improved the stability of cycloserine under accelerated stress conditions (53.3 ± 2.2% vs 1.7 ± 0.2%). DSC results confirmed the compatibility between calcium hydroxide and the cycloserine, and SEM results confirmed that it was evenly distributed around the cycloserine. Calcium hydroxide also showed more than 90% cycloserine dissolution within 15 minutes. Therefore, the calcium hydroxide and cycloserine composite particles may be candidates for cycloserine oral pharmaceuticals with enhanced drug stability.

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