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Usage of Korean Herbal Medicine Banhabaekchulcheonmatang-Analysis of Korean Clinical Studies

반하백출천마탕을 사용한 국내 임상연구 분석

  • Nokwon Kim (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Minjung Bae (Department of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Youngju Yun (Department of Integrative Medicine, School of Korean Medicine, Pusan National University)
  • 김녹원 (부산대학교 한의학전문대학원 한의학과) ;
  • 배민정 (부산대학교 한의학전문대학원 한의학과) ;
  • 윤영주 (부산대학교 한의학전문대학원 동서협진의학)
  • Received : 2024.03.06
  • Accepted : 2024.04.14
  • Published : 2024.04.30

Abstract

Objectives : To investigate the clinical usage of Banhabaekchulcheonmatang (BBCT), this study reviewed clinical studies conducted in Korea. Method : Literature search was performed on four Korean database; OASIS, RISS, KTKP and NDSL. Studies published before July 2023 were categorized and analyzed according to the target disease. Results : Fifty-four studies including 36 single case reports and 18 case series were included in this review and the total number of case patients was 79. There were 24 patients with peripheral vertigo such as benign paraoxysmal positional vertigo and Meniere's disease, 17 with central vertigo such as cerebellar infarction, 15 with vertigo accompanied by digestive symptoms, 13 with headache, and 10 with other diseases. Vertigo treatment accounted for more than 70% of the total case and there was no cases of hypertension and dementia. The BBCT formulation used was decoction in 69 patients (87.3%), powder in 7 patients (8.9%), and combination of decoction and powder in 3 patients (3.8%). Conclusion : Clinical research should be accumulated to expand the use of BBCT in the treatment of hypertension and dementia. In order to increase the use of insurance-covered extract preparation, it is necessary to make an effort to include the various diseases actually treated with BBCT in the indications.

Keywords

References

  1. National institute for Korean Medicine Development, Gallup Korea. 2022 National survey on Herbal Medicine Consumption Survey. 2022.
  2. Hwang DY. Bangyakhappyeon. 1st ed. Seoul: Youngrimsa. 2002:235
  3. Guo Z. The effect of chinese herbal medicine Banxia Baizhu Tianma Decoction for the treatment of vertebrobasilar insufficiency vertigo: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 2017:31:27-38
  4. Lin J, Wang Q., Xu, S, Zhou S, Zhang X, Yao K. Banxia baizhu tianma decoction, a Chinese herbal formula, for hypertension: Integrating meta-analysis and network pharmacology. Frontiers in Pharmacology. 2022:13:94-111
  5. Miwa T, Kanemaru SI. Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study. World Journal of Clinical Cases. 2022:10(20):6811-6824 https://doi.org/10.12998/wjcc.v10.i20.6811
  6. Okayasu T, Mitani K, Kitahara T. Reviewing Kampo medicine (Traditional Japanese Herbal Medicine) for otology/neurotology diseases. Auris Nasus Larynx. 2024:51(1):25-30
  7. Lee HJ, Seong YJ, Moon KJ, Kim JB, Kim GW, Shin HM. Enhanced Vasorelaxation of BanhabackchulChunma-Tang and Involved Mechanism. Journal of Physiology & Pathology in Korean Medicine. 2005:19(5):1311-1316
  8. Kim SY, Won HY, Choi CW, Kim KS, Kim KO, Lee DW. The effects of Banhabaekchulchunma-Tang (BCT) on Dementia induced by focal brain ischemic injury in rats. Journal of Oriental Neuropsychiatry. 2006:17(2):61-73
  9. Shin IS, Jeon WY, Shin HK, Cha SW, Lee MY. Banhabaekchulchunma-tang, a traditional herbal formula attenuates absolute ethanol-induced gastric injury by enhancing the antioxidant status. BMC Complementary and Alternative Medicine. 2013:13(1):1-8 https://doi.org/10.1186/1472-6882-13-1
  10. Kim GL, Hong CH, Lee KY. Banhabaeckchulchunma-tang for Benign Paroxysmal Positional Vertigo: A Systematic Review and Metaanalysis. Journal of Korean Med Ophthalmol Otolaryngol Dermatol. 2021:34(4):71-89
  11. Gwon GH, Oh SH, Park ES, Kim MH, Hong SH, Song GJ, Park EY. The Effect of Banhabaekchulcheonma-tang on Benign Paroxysmal Positional Vertigo: A Systematic Review Using the CNKI Database. The Journal of Internal Korean Medicine. 2021:42(4):572-589 https://doi.org/10.22246/jikm.2021.42.4.572
  12. Oh HJ, Shin SW, Lee EJ, Chung WS. Chinese Herbal Medicine for Cervicogenic Dizziness: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2022:1-32
  13. Cheong SS, Kang SY, Yoon JW, Ryu HH, Yoon JC, Kim JM, Lee SK, Sung KK. Three Cases treated with Banhabackchulchunma-tanggami and Backchul-tanggami on patients showing BPPV-like-symptom. The Korean Journal of Joongpoong. 2003:4(1):85-91.
  14. Lee SG, Lee JH, Kim YE. Four Cases of Benign Paroxysmal Positional Vertigo Diagnosed as Damhun. Journal of Physiology & Pathology in Korean Medicine. 2009:23(3):734-739.
  15. Choi YY, Byun JA, Kim SY, Hwang ML, Ahn JH, Jung HA. Three Cases of Acute Benign Paroxysmal Positional Vertigo Improved after Korean Medicine Treatment. Journal of Korean Med Ophthalmol Otolaryngol Dermatol. 2021:34(4):134-145.
  16. Ahn SH, Choi JS, Cho CS, Kim CJ. Five Case Report of Peripheral Vertigo Diagnosed Dam Hun with Oriental Medcal Treatment-Banhabaeckchulchunma-tang gagam-. Journal of Physiology & Pathology in Korean Medicine. 2009:23(1):263-268.
  17. Lee SY, Kim MY, Kim YJ, Choi WW, Min IK, Park JY, Jung WS, Moon SK, Cho KH, Kim YS. One Case of Meniere's Disease. The Korean Journal of Joongpoong. 2008:9(1):40-45.
  18. Lee SE, Kim JH, kim YB. Oriental medical treatment in Meniere's disease. The Journal of Korean Acupunture & Moxibustion Society. 2004:21(6):269-279
  19. Kim KS, Kim YB, Kim HS, Park OS, Kim HJ. Two Clinical Cases of Vertigo. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology 2005:18(3):148-157
  20. Lee KJ, Nam HJ, Kim YB. Two cases of Meniere's disease. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 2005:18(3):158-164.
  21. Park YH, Yu MK, Choi JH, Kim JH, Park SY. A Case of Vestibulopathy With Vertigo. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 2005:18(2):93-98.
  22. Yi GH, Hong SU. A case of improved Wegener's granulomatosis with Oriental- Western Medicine Treatment. The Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology. 2016:29(4):206-217. https://doi.org/10.6114/jkood.2016.29.4.206
  23. Kim MH, Heo GY, Kang HK, Nam IR, Kim M, Lee I, Kwon JN, Kim SY, Yun YJ, Choi JY, Han CW, Park SJ, Hong JW. A Case Report of Persistent Postural-Perceptual Dizziness Treated with Korean Medicine. The Journal of Internal Korean Medicine. 2022:43(4):769-778. https://doi.org/10.22246/jikm.2022.43.4.769
  24. Han SH, Nam HS, Kim MK, Han IS, Sun SH. Four Cases of Dizziness Alleviated by Korean Medicine Treatment with Gami-banhabakchulchunma-tang. The Journal of Internal Korean Medicine. 2019:40(5):967-973.
  25. Kim SM, Sun JJ, Jung JH, Choi CM, Sin WJ, Rhee JW, Jung WS, Moon SK, Cho KH, Kim YS, Bae HS. A case of vertigo patient after cerebellar infarction improved by oriental medical treatment. The Korean Oriental Chronic Disease. 2005:10(1):62-68
  26. Choi KS, Lee HH, Shin YS, Kim JS, Kim YS, Han YH, Im MK. Case Studies of Central Vertigo Patients Diagnosed as Cerebellar infarction. Journal of Physiology & Pathology in Korean Medicine. 2008:22(6):):1589-1593.
  27. Cho YY, Shin JH, Baik TH, Park HM, Sun SH. A Case Study of a Patient with a Cerebellar Infarction, Dizziness, and Ataxia Who Was Treated with Traditional Korean Medicine. The Journal of Internal Korean Medicine. 2017:38(2):270-275
  28. Kim SY, Jung ES, Cha JY, Seol IC, Kim YS, Jo HK, Yoo HR. A Case of Cerebellar Infarction Patient with Vertigo, Nausea, and Vomiting. The Journal of Internal Korean Medicine. 2018:39(5):853-862.
  29. Shin JE, Kang JY, Yang JH, Won SY, Yoo HR, Kim YS, Seol IC. Korean Medicine Treatment for Anterior Inferior Cerebellar Artery Infarction: A Case Report. The Journal of Internal Korean Medicine. 2022:43(2):166-174. https://doi.org/10.22246/jikm.2022.43.2.166
  30. Lim MA, Lee HJ, Seo HS, Kim PK, Kim JW. Two Case Reports about Traditional Korean Medicine Treatment in Patients with Central Dizziness and Cerebellar Ataxia. The Journal of Internal Korean Medicine. 2017:38(5):744-752. https://doi.org/10.22246/jikm.2017.38.5.744
  31. Shim MK, Chun CY, Park JH. A case of Wallenberg's Syndrome. The Journal of Internal Korean Medicine. 2000:21(3):521-524.
  32. Jang HH, Yang HD, Min YK, Son IH, Suk SH, Min SJ, Kang HW, Lyu YS, Lee GM. The case of study of Wallenberg's Syndrome the oriental & occidental cooperative therapeutic model. The Journal of Oriental Neuropsychiatry. 2001:12(1):219-229
  33. Yang JH, Kang JY, Choi IW, Ryu JY, Yoo HR, Kim Ys, Seol IC. A Case Report of Korean Medicine Treatment of Lateral Medullary Infarction with Central Dizziness and Hypoesthesia. The Journal of Internal Korean Medicine. 2021:42(5):982-990. https://doi.org/10.22246/jikm.2021.42.5.982
  34. Kim YD, Han SW. Effecf of Banhabaechoolcheunma-tang on the patient of cerebellar hemorrhage: A case report. The Journal of Oriental Rebabilitation Medicine. 2001:12(4):217-224
  35. Park SW, Yun JM, Lee MG, Lee SW, Kang BG, Lee SE, Kim YJ, Son JW, Lee I, Moon BS. Case of the Pulmonary Thromboembolism in a Patient withLacunar Cerebral Infarction by the Integrated Therapy of Korean and Western Medicine. Journal of Physiology & Pathology in Korean Medicine. 2005:19(6):1676-1680.
  36. Shim SS, Lee HS, Ahn JY, Chae HN, Yun JM, Moon BS. A Case Report of a Patient with Wernicke's Encephalopathy Complaining of Quadriplegia, Ataxia, and Impaired Cognition Improved by Korean Medicine Treatment. The Journal of Internal Korean Medicine. 2020:41(5):777-786. https://doi.org/10.22246/jikm.2020.41.5.777
  37. Yim TB, Jeon GR, Kim SY, Jeong HS, Cho SY, Park SU, Park JM, Ko CN. A Case of Korean Medical Treatment on Multiple System Atrophy with Gait Disturbance. The Journal of Internal Korean Medicine. 2020:41(5):821-829. https://doi.org/10.22246/jikm.2020.41.5.821
  38. Kim JH, Kim HY, Won SY, Ryu JY, Jung ES, Yoo HR, Seol IC, Kim IS. A Case Report on Treating Post-stroke Visual Impairment with Gami-banhabakchulchunma-tang and Acupuncture. The Journal of Internal Korean Medicine. 2021:42(5):1045-1053.
  39. Heo M, Kim IS, Seol IC. A clinical study of one patients suffering headache after administering banhabakchulchunma-tang. The journal of Daejeon university Research Institute of Korean Medicine: 2005:14(2):127-131
  40. Seo BI. A clinical study of banhabakchulcheonmatang on a patient with headache due to retention of phlegm. The Korea Journal of Herbology. 2007:22(2):79-82.
  41. Lee GD, Han SS, An CJ, Seo JE. Two cases of patients with migraine recovered by trigger point treatment. The Journal of Internal Korean Medicine. 2001:22(3):443-452.
  42. Lee SH, Lee JS, Jung HS, Choi WC, Kim KS. A Case Report of Non-small Cell Lung Cancer with Brain Metastasis Patient Treated with Banhabaekchulchoenma-tang Gagambang. The Journal of Korean Traditional Oncology. 2009:14(1):45-52.
  43. Kim MG, Cho HB, Kim GW, Koo BS. Korean Medicine Treatment for a Patient with Cluster Headache: A Case Report. The journal of Oriental Neuropsychiatry. 2022:33(2):215-225.
  44. Shin JH, Cho YY, Baik TH, Park HM, Sun SH. Four Clinical Cases of Tension-Type Headache Patients Treated with Different Types of Korean Medicine, including Gunoe-tang. The Journal of Internal Korean Medicine. 2017:38(2):195-200. https://doi.org/10.22246/jikm.2017.38.2.195
  45. Cha HJ, Lee CW, Chu CN, Kim HJ, Seo YM, Park SJ. A case report of a panic disorder patient suffering from a chronic headache. The journal of Oriental Neuropsychiatry. 2008:19(2):279-288
  46. Kim HK. A Clinical Report of severe Phlegmsyncope Type Headache patient due to Deficiency Syndrome of Spleen and Stomach Treated with Banhabaekchulchoenma-tang. The journal of Korean Hyungsang medicine. 2009:10(1):282-283
  47. Baek IK, Yoo HR, Cho HK, Seol IC, Kim YS. Clinical Report of Phlegm-syncope Type Headache Patient Treated with Oriental Medicine. Journal of Physiology & Pathology in Korean Medicine. 2013:27(1):139-141.
  48. Jeong DU. A Clinical Report of Headache Treated with Banhabaekchulchoenma-tang. The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology. 1989:2(1):77-78.
  49. Ku EJ, Lee JW. A case report of autonomic seizure with recurrent vomiting, abdominal pain and headache. Journal of Korean Medicine, 1996:17(2):394-404.
  50. Kim TS, Go SK. Case study on one case of hepatoma. The Journal of Internal Korean Medicine. 1998:19(1):73-81
  51. Won JH, Moon YH, Kim HJ, Yoon JC, Kim TG, Bae NG, Lee JB. A Case of Psychogenic Vomiting Improved with Banhabakchulchunma-tang. Journal of Physiology & Pathology in Korean Medicine. 2001:15(6):1022-1024.
  52. Choi BT, Kim HJ. Clinical Case of the Phlegmretention Type Patient with Urticaria, Headache-Vertigo Symptoms. Journal of Physiology & Pathology in Korean Medicine. 2008:22(1):252-255.
  53. Lee HW, Chang YJ, Hong SU. A Case of Globus Hystericus caused by psychological, digestive disorder. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology. 2013:26(2):88-97 https://doi.org/10.6114/jkood.2013.26.2.088
  54. Jung DH, Shin WS, Park WH, Cha YY, Choi WJ. A Case Report for an Eating Disorders with Banhabaeckchulchunma-tang and Acupuncture Treatment. Journal of Korean Medicine for Obesity Research. 2015:15(1):45-50. https://doi.org/10.15429/jkomor.2015.15.1.45
  55. Chu HM, Moon YJ, Kim Ch, Park KT, Won JH. A Case of Hyperthyroidism in a Patient with Improved FT4 Levels Following Treatment with Traditional Korean Medicine. The Journal of Internal Korean Medicine. 2017:38(4):501-508. https://doi.org/10.22246/jikm.2017.38.4.501
  56. Han AR, Lee HJ, Cho YJ, Keum CY, Yoon CR, Choi SH, Ha NY, Kim JS. A Case Study of Korean Medical Treatment for Indigestion and Abdominal Pain after Gastrectomy. The Journal of Internal Korean Medicine. 2022:43(2):201-211. https://doi.org/10.22246/jikm.2022.43.2.201
  57. Park SK, Kim JS, Hong JH, Hong SS, Lim JH, Han SY, Kim JS, Yoon SH, Ryu BH, Ryu KW. An evaluation & Clinical report on three cases of functional Dyspepsia. The Journal of Internal Korean Medicine. 2002:23(2):244-252.
  58. Koo JS, Kim BH, Seo BI. A clinical study of two patients on vertigo with Banhabaekchulcheonma-tang gamibang. The Korea Journal of Herbology. 2015:30(5):1-6.
  59. Park JS, Kil BH, Kim DW, Jung DH, Jo HM, Kim CW, Hong WK, Jeong YK. Two Case Reports of Anxiety Disorder Patients with Gastrointestinal Symptoms Treated with Traditional Korean Medicine. The Journal of Internal Korean Medicine. 2020:41(2):177-185. https://doi.org/10.22246/jikm.2020.41.2.177
  60. Kim JE, Yang SJ, Cho SH, Yeo EJ, Park KM, Kim KO. A Case Report of Conversion Disorder with Climacteric Symptoms. The Journal of Oriental Obstetrics & Gynecology. 2012:25(4):144-153.
  61. Kim NY, Yoon MJ, Cho NK, Choi HS, Kim SM, Kim KS. Treatment of Dizziness with Polycythemia Vera by Korean Medicine: Case Report. The Journal of Internal Korean Medicine. 2020:41(6):1265-1273. https://doi.org/10.22246/jikm.2020.41.6.1265
  62. Kim JU, Choi SY, Hwang WJ, Lee SH, Yoo IS. Clinical studies on Ossification of ligaments within spinal canal - 3 cases of OPLL and 3 cases of OLF -. Journal of Acupuncture Research. 2004:21(6):127-150
  63. Lee DJ, Lee ME, Kwon K, Seo HS. A Case Report of Diabetic Retinopathy Vitreous Hemorrhage. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology. 2018:31(2):152-159.
  64. Kim KJ. A Clinical Case of Lymphadenopathy and Hearing Loss after Covid-19 Vaccination. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology. 2022: 35(3):95-106
  65. Lee JH, Yu SA, Lee SY. Five Case Reports on Peripheral Facial Palsy in Children. The Journal of Pediatrics of Korean Medicine. 2013:27(3):20-28 https://doi.org/10.7778/JPKM.2013.27.3.020
  66. Shim SS, Park IH, Park CE, Chung WS. Korean Medicine Treatment (Banhabakchulchunma-tang) for an Obese Patient With Hypothyroidism: Two Case Reports. Journal of Korean Medicine for Obesity Research. 2023:23(1):42-50.
  67. Yeun GY. Oriental Clinical Prescription Medicine. Seoul: Myungbo publisher. 1973:103, 69.
  68. Xiong XJ, Yang XC, Liu W, Feng B, Ma JH, DU XL, Wang PQ, Chu FY, Li J, Wang J. Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2012:1-12
  69. Lu Y, Li J, Xu H, Wang CD. Oral traditional Chinese medicine for vestibular Migraine: A systematic review and meta-analysis. Journal of Clinical Neuroscience. 2023:110:100-108
  70. Chang YY, Tsai YT, Lai JN, Yeh CH, Lin SK. The traditional Chinese medicine prescription patterns for migraine patients in Taiwan: A population-based study. Journal of Ethnopharmacology. 2014:151(3):1209-1217. https://doi.org/10.1016/j.jep.2013.12.040
  71. Ministry of health, labour and welfare, The 8th NDB open data. Usage status of National health insurance herbal prescription in Japan. Available from: https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000177221_00012.html.
  72. Kyungbang Pharmacy. 2021 Disease code list.
  73. Need to create a virtuous cycle structure to revitalize herbal medicines. Available from: https://www.akomnews.com/bbs/board.php?bo_table=news&wr_id=36790
  74. Health Insurance Review and Assessment Service. Claim trends of 2022 National health insurance herbal prescription.
  75. Lim DW, Ahn JY, Yu GR, Kim JE, Park WH. Study on the distribution in major disease category and frequency of clinical usage of national health insurance herbal prescription based on analysis on KCD8 disease code of indications. Journal of Korean Medicine. 2023:44(1):1-15