Journal of Korean society of Dental Hygiene (한국치위생학회지)

Korean Society of Dental Hygiene (한국치위생학회)
권호 표지
DOI QR코드

DOI QR Code

Changes in periodontal pathogens and chronic disease indicators through adjunctive probiotic supplementation : a case report

보조적 프로바이오틱스 복용을 통한 치주 병원성 세균 및 전신질환 지표 변화: 증례보고

  • Mu-Yeol Cho (Apple Tree Institute of Biomedical Science & Apple Tree Dental Hospital, Apple Tree Medical Foundation) ;
  • In-Seong Hwang (Apple Tree Institute of Biomedical Science & Apple Tree Dental Hospital, Apple Tree Medical Foundation) ;
  • Young-Yeon Kim (Apple Tree Institute of Biomedical Science & Apple Tree Dental Hospital, Apple Tree Medical Foundation) ;
  • Hye-Sung Kim (Apple Tree Institute of Biomedical Science & Apple Tree Dental Hospital, Apple Tree Medical Foundation)
  • 조무열 (사과나무의료재단 사과나무의생명연구소 & 사과나무치과병원) ;
  • 황인성 (사과나무의료재단 사과나무의생명연구소 & 사과나무치과병원) ;
  • 김영연 (사과나무의료재단 사과나무의생명연구소 & 사과나무치과병원) ;
  • 김혜성 (사과나무의료재단 사과나무의생명연구소 & 사과나무치과병원)
  • Received : 2024.03.08
  • Accepted : 2024.04.10
  • Published : 2024.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: This case study aimed to evaluate changes in periodontal pathogens and systemic disease indicators following the adjunctive use of probiotics for periodontal treatment. Methods: Two adults, a 64-year-old male and 71-year-old female, were selected with ethical approval and underwent comprehensive oral and systemic health assessments before and after probiotic intake with periodontal debridement. Results: There was a significant reduction in the periodontal pathogens, particularly Porphyromonas gingivalis and Treponema forsythia, and no adverse systemic indicators were observed. Moreover, a trend toward improved lipid profiles was noted, suggesting a potential positive impact on systemic health. Conclusions: This study shows the potential role of probiotics in enhancing oral health and preventing systemic diseases, thus highlighting the need for further research and clinical trials.

Keywords

References

  1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366(9499):1809-20. https://doi.org/10.1016/S0140-6736(05)67728-8
  2. Han YW, Wang X. Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res 2013;92(6):485-91. https://doi.org/10.1177/0022034513487559
  3. Ford PJ, Gemmell E, Chan A, Carter CL, Walker PJ, Bird PS, et al. Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study. Oral Microbiol Immunol 2006;21(4):206-11. https://doi.org/10.1111/j.1399-302X.2006.00276.x
  4. Gonzales-Marin C, Spratt DA, Allaker RP. Maternal oral origin of Fusobacterium nucleatum in adverse pregnancy outcomes as determined using the 16S-23S rRNA gene intergenic transcribed spacer region. J Med Microbiol 2013;62(Pt 1):133-44. https://doi.org/10.1099/jmm.0.049452-0
  5. Martinez-Martinez RE, Abud-Mendoza C, Patino-Marin N, Rizo-Rodriguez JC, Little JW, Loyola-Rodriguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol 2009;36(12):1004-10. https://doi.org/10.1111/j.1600-051X.2009.01496.x
  6. Cobb CM. Non-surgical pocket therapy: mechanical. Ann Periodontol 1996;1(1):443-90. https://doi.org/10.1902/annals.1996.1.1.443
  7. Heitz-Mayfield LJ. Systemic antibiotics in periodontal therapy. Aust Dent J 2009;54(S1):S96-101. https://doi.org/10.1111/j.1834-7819.2009.01147.x
  8. Teughels W, Feres M, Oud V, Martin C, Matesanz P, Herrera D. Adjunctive effect of systemic antimicrobials in periodontitis therapy: a systematic review and meta-analysis. J Clin Periodontol 2020;47(S22):257-81. https://doi.org/10.1111/jcpe.13264
  9. Gillam DG, Turner W. Antibiotics in the treatment of periodontal disease: a guide for the general dental practitioner. Prim Dent J 2014;3(3):43-7. https://doi.org/10.1308/205016814812736862
  10. Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, et al. An update on the use and investigation of probiotics in health and disease. Gut 2013;62(5):787-96. https://doi.org/10.1136/gutjnl-2012-302504
  11. Stamatova I, Meurman JH. Probiotics and periodontal disease. Periodontol 2000 2009;51(1):141-51. https://doi.org/10.1111/j.1600-0757.2009.00305.x
  12. Allaker RP, Stephen AS. Use of Probiotics and Oral Health. Curr Oral Health Rep 2017;4(4):309-18. https://doi.org/10.1007/s40496-017-0159-6
  13. Martin-Cabezas R, Davideau JL, Tenenbaum H, Huck O. Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis. J Clin Periodontol 2016;43(6):520-30. https://doi.org/10.1111/jcpe.12545
  14. Choi Y. Improvement of periodontal disease by novel probiotics Lactobacillus curvatus SMFM2016-NK[Doctoral dissertation]. Seoul: Sookmyung Women's University, 2020.
  15. Fleiss JL, Park MH, Chilton NW, Alman JE, Feldman RS, Chauncey HH. Representativeness of the "Ramfjord teeth" for epidemiologic studies of gingivitis and periodontitis. Community Dent Oral Epidemiol 1987;15(4):221-4. https://doi.org/10.1111/j.1600-0528.1987.tb00525.x
  16. Laitinen K, Poussa T, Isolauri E, Nutrition AMI, Intestinal Microbiota G. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomized controlled trial. Br J Nutr 2009;101(11):1679-87. https://doi.org/10.1017/S0007114508111461
  17. Hoppu U, Isolauri E, Koskinen P, Laitinen K. Maternal dietary counseling reduces total and LDL cholesterol postpartum. Nutrition 2014;30(2):159-64. https://doi.org/10.1016/j.nut.2013.07.009
  18. Canut-Delgado N, Giovannoni ML, Chimenos-Kustner E. Are probiotics a possible treatment of periodontitis? probiotics against periodontal disease: a systematic review. Br Dent J 2021:1-7. https://doi.org/10.1038/s41415-021-3624-5
  19. von Troil-Linden B, Torkko H, Alaluusua S, Jousimies-Somer H, Asikainen S. Salivary levels of suspected periodontal pathogens in relation to periodontal status and treatment. J Dent Res 1995;74(11):1789-95. https://doi.org/10.1177/00220345950740111201
  20. Invernici MM, Salvador SL, Silva PHF, Soares MSM, Casarin R, Palioto DB, et al. Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial. J Clin Periodontol 2018;45(10):1198-210. https://doi.org/10.1111/jcpe.12995
  21. Vivekananda MR, Vandana KL, Bhat KG. Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial. J Oral Microbiol 2010;2(1):5344. https://doi.org/10.3402/jom.v2i0.5344
  22. Park DY, Hwang JY, Kim YJ, Lee DH, Kim YY, Kim HS, Hwang IS. Antimicrobial activity of Limosilactobacillus fermentum strains isolated from The humanoral cavity against Streptococcus mutans. Sci Rep 2023;13(1):7969. https://doi.org/10.1038/s41598-023-35168-7
  23. Fiorillo L, Cervino G, Laino L, D'Amico C, Mauceri R, Tozum TF, et al. Porphyromonas gingivalis, periodontal and systemic implications: a systematic review. Dent J (Basel) 2019;7(4):114. https://doi.org/10.3390/dj7040114
  24. Fan Z, Tang P, Li C, Yang Q, Xu Y, Su C, Li L. Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms. J Oral Microbiol 2023;15(1):2145729. https://doi.org/10.1080/20002297.2022.2145729
  25. Sharma S, Kurpad AV, Puri S. Potential of probiotics in hypercholesterolemia: a meta-analysis. Indian J Public Health 2016;60(4):280-6. https://doi.org/10.4103/0019-557X.195859
  26. Wu Y, Zhang Q, Ren Y, Ruan Z. Effect of probiotic Lactobacillus on lipid profile: a systematic review and meta-analysis of randomized, Controlled trials. PLoS One 2017;12(6):e0178868. https://doi.org/10.1371/journal.pone.0178868
  27. Park DY, Hwang JY, Kim YJ, Kim YY, Kim HS, Hwang IS. Complete genome sequence of hydrogen peroxide-producing Limosilactobacillus fermentum DM072 isolated from the human oral cavity. Microbiol Resour Announc 2022;11(12):e0089722. https://doi.org/10.1128/mra.00897-22
  28. Park DY, Hwang JY, Kim YJ, Kim YY, Kim HS, Hwang IS. Complete genome sequence of Lactiplantibacillus plantarum strain DM083 isolated From human tongue coating. Microbiol Resour Announc 2022;11(10):e0067522. https://doi.org/10.1128/mra.00675-22
  29. Park DY, Hwang JY, Kim YJ, Kim YY, Kim HS, Hwang IS. Whole-genome sequence of Limosilactobacillus fermentum strain DM075, isolated from the humanoral cavity. Microbiol Resour Announc 2022;11(11):e0081922. https://doi.org/10.1128/mra.00819-22
  30. Szkaradkiewicz AK, Stopa J, Karpinski TM. Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis. Arch Immunol Ther Exp (Warsz) 2014;62(6):495-500. https://doi.org/10.1007/s00005-014-0277-y