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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Memory allocation at the neuronal and synaptic levels

  • HyoJin Park (Center for Cognition and Sociality, Life Science Institute, Institute for Basic Science (IBS)) ;
  • Bong-Kiun Kaang (Center for Cognition and Sociality, Life Science Institute, Institute for Basic Science (IBS))
  • Received : 2023.09.15
  • Accepted : 2023.11.10
  • Published : 2024.04.30
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Abstract

Memory allocation, which determines where memories are stored in specific neurons or synapses, has consistently been demonstrated to occur via specific mechanisms. Neuronal allocation studies have focused on the activated population of neurons and have shown that increased excitability via cAMP response element-binding protein (CREB) induces a bias toward memory-encoding neurons. Synaptic allocation suggests that synaptic tagging enables memory to be mediated through different synaptic strengthening mechanisms, even within a single neuron. In this review, we summarize the fundamental concepts of memory allocation at the neuronal and synaptic levels and discuss their potential interrelationships.

Keywords

Acknowledgement

This work was supported by the Institute for Basic Science (IBS-R001-D3).

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