Pediatric Infection and Vaccine

The Korean Society of Pediatric Infectious Diseases (대한소아감염학회)
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Immune Reconstitution Inflammatory Syndrome-Like Reaction During the Treatment of Pneumocystis jirovecii Pneumonia in an Infant With Severe Combined Immunodeficiency

  • Ching-Yu Lin (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) ;
  • Sung-Min Lim (Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine) ;
  • Soo-Yeon Kim (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) ;
  • Seung-Min Hahn (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) ;
  • Jong-Gyun Ahn (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine) ;
  • Ji-Man Kang (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine)
  • Received : 2023.08.18
  • Accepted : 2023.12.20
  • Published : 2024.04.25
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Abstract

The effectiveness of corticosteroids in preventing immune reconstitution inflammatory syndrome in non-human immunodeficiency viruses Pneumocystis carinii pneumonia (PCP) patients, such as severe combined immunodeficiency (SCID) patients, is controversial. We experienced a paradoxical reaction during severe PCP treatment in a SCID infant, which responded well to adjuvant corticosteroids.

인체면역결핍바이러스 감염자의 페포자충폐렴 치료에 있어 보조적 스테로이드 치료의 효용성은 잘 알려진데 반해, 비인체면역결핍바이러스 면역저하자에서의 페포자충폐렴 치료에 있어서의 보조적 스테로이드 치료의 효용성은 논란의 여지가 있다. 본 연구자들은 비인체면역결핍바이러스 면역저하자인 중증복합면역결핍증 영아에서 이환된 중증페포자충폐렴를 치료하던 중 면역재구성염증증후군 유사현상을 관찰하였으며, 보조적 스테로이드 치료에 잘 반응하였기에 이를 보고하는 바이다.

Keywords

Acknowledgement

We wish to thank the patient and his family for their participation in this study.

References

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