DOI QR코드

DOI QR Code

악성 췌장 병변 진단에서 인공지능기술을 이용한 초음파내시경의 응용

Application of Endoscopic Ultrasound-based Artificial Intelligence in Diagnosis of Pancreatic Malignancies

  • 안재희 (한림대학교 의과대학 강남성심병원 소화기내과 ) ;
  • 정회훈 (한림대학교 의과대학 강남성심병원 소화기내과 ) ;
  • 박재근 (한림대학교 의과대학 강남성심병원 소화기내과 )
  • Jae Hee Ahn (Department of Gastroenterology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Hwehoon Chung (Department of Gastroenterology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jae Keun Park (Department of Gastroenterology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
  • 투고 : 2024.04.09
  • 심사 : 2024.04.19
  • 발행 : 2024.04.20

초록

Pancreatic cancer is a highly fatal malignancy with a 5-year survival rate of < 10%. Endoscopic ultrasound (EUS) is a useful noninvasive tool for differential diagnosis of pancreatic malignancy and treatment decision-making. However, the performance of EUS is suboptimal, and its accuracy for differentiating pancreatic malignancy has increased interest in the application of artificial intelligence (AI). Recent studies have reported that EUS-based AI models can facilitate early and more accurate diagnosis than other preexisting methods. This article provides a review of the literature on EUS-based AI studies of pancreatic malignancies.

키워드

참고문헌

  1. Goyal H, Sherazi SAA, Gupta S, et al. Application of artificial intelligence in diagnosis of pancreatic malignancies by endoscopic ultrasound: a systemic review. Therap Adv Gastroenterol 2022;15:17562848221093873. https://doi.org/10.1177/17562848221093873 
  2. Ang TL, Kwek ABE, Wang LM. Diagnostic endoscopic ultrasound: technique, current status and future directions. Gut Liver 2018;12:483-496. https://doi.org/10.5009/gnl17348 
  3. Harmsen FR, Domagk D, Dietrich CF, Hocke M. Discriminating chronic pancreatitis from pancreatic cancer: contrast-enhanced EUS and multidetector computed tomography in direct comparison. Endosc Ultrasound 2018;7:395-403. https://doi.org/10.4103/eus.eus_24_18 
  4. Singh S. Cousins of artificial intelligence. 2018. https://towardsdatascience.com/cousins-ofartificial-intelligencedda4edc27b55 (accessed October 19, 2023). 
  5. Tonozuka R, Mukai S, Itoi T. The role of artificial intelligence in endoscopic ultrasound for pancreatic disorders. Diagnostics (Basel) 2020;11:18. https://doi.org/10.3390/diagnostics11010018 
  6. Schmidhuber J. Deep learning in neural networks: an overview. Neural Netw 2015;61:85-117. https://doi.org/10.1016/j.neunet.2014.09.003 
  7. Xu W, Liu Y, Lu Z, et al. A new endoscopic ultrasonography image processing method to evaluate the prognosis for pancreatic cancer treated with interstitial brachytherapy. World J Gastroenterol 2013;19:6479-6484. https://doi.org/10.3748/wjg.v19.i38.6479 
  8. Zhu M, Xu C, Yu J, et al. Differentiation of pancreatic cancer and chronic pancreatitis using computer-aided diagnosis of endoscopic ultrasound (EUS) images: a diagnostic test. PLoS One 2013;8:e63820. https://doi.org/10.1371/journal.pone.0063820 
  9. Zhang MM, Yang H, Jin ZD, Yu JG, Cai ZY, Li ZS. Differential diagnosis of pancreatic cancer from normal tissue with digital imaging processing and pattern recognition based on a support vector machine of EUS images. Gastrointest Endosc 2010;72:978-985. https://doi.org/10.1016/j.gie.2010.06.042 
  10. Das A, Nguyen CC, Li F, Li B. Digital image analysis of EUS images accurately differentiates pancreatic cancer from chronic pancreatitis and normal tissue. Gastrointest Endosc 2008;67:861-867. https://doi.org/10.1016/j.gie.2007.08.036 
  11. Saftoiu A, Vilmann P, Gorunescu F, et al. Efficacy of an artificial neural network-based approach to endoscopic ultrasound elastography in diagnosis of focal pancreatic masses. Clin Gastroenterol Hepatol 2012;10:84-90.e1. https://doi.org/10.1016/j.cgh.2011.09.014 
  12. Saftoiu A, Vilmann P, Gorunescu F, et al. Neural network analysis of dynamic sequences of EUS elastography used for the differential diagnosis of chronic pancreatitis and pancreatic cancer. Gastrointest Endosc 2008;68:1086-1094. https://doi.org/10.1016/j.gie.2008.04.031 
  13. Ozkan M, Cakiroglu M, Kocaman O, et al. Age-based computer-aided diagnosis approach for pancreatic cancer on endoscopic ultrasound images. Endosc Ultrasound 2016;5:101-107. https://doi.org/10.4103/2303-9027.180473 
  14. Norton ID, Zheng Y, Wiersema MS, Greenleaf J, Clain JE, Dimagno EP. Neural network analysis of EUS images to differentiate between pancreatic malignancy and pancreatitis. Gastrointest Endosc 2001;54:625-629. https://doi.org/10.1067/mge.2001.118644 
  15. Kuwahara T, Hara K, Mizuno N, et al. Usefulness of deep learning analysis for the diagnosis of malignancy in intraductal papillary mucinous neoplasms of the pancreas. Clin Transl Gastroenterol 2019;10:e00045. https://doi.org/10.14309/ctg.0000000000000045 
  16. Marya NB, Powers PD, Chari ST, et al. Utilisation of artificial intelligence for the development of an EUS-convolutional neural network model trained to enhance the diagnosis of autoimmune pancreatitis. Gut 2021;70:1335-1344. https://doi.org/10.1136/gutjnl-2020-322821 
  17. Gu J, Pan J, Hu J, et al. Prospective assessment of pancreatic ductal adenocarcinoma diagnosis from endoscopic ultrasonography images with the assistance of deep learning. Cancer 2023;129:2214-2223. https://doi.org/10.1002/cncr.34772 
  18. Tonozuka R, Itoi T, Nagata N, et al. Deep learning analysis for the detection of pancreatic cancer on endosonographic images: a pilot study. J Hepatobiliary Pancreat Sci 2021;28:95-104. https://doi.org/10.1002/jhbp.825 
  19. Hsiao CY, Yang CY, Wu JM, Kuo TC, Tien YW. Utility of the 2006 Sendai and 2012 Fukuoka guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas: a single-center experience with 138 surgically treated patients. Medicine (Baltimore) 2016;95:e4922. https://doi.org/10.1097/MD.0000000000004922 
  20. Mendoza Ladd A, Diehl DL. Artificial intelligence for early detection of pancreatic adenocarcinoma: the future is promising. World J Gastroenterol 2021;27:1283-1295. https://doi.org/10.3748/wjg.v27.i13.1283 
  21. Price WN. Big data and black-box medical algorithms. Sci Transl Med 2018;10:eaao5333. https://doi.org/10.1126/scitranslmed.aao5333 
  22. Gerke S, Minssen T, Cohen G. Ethical and legal challenges of artificial intelligence-driven healthcare. In: Bohr A, Memarzadeh K, eds. Artificial intelligence in healthcare. London: Academic Press, 2020:295-336. 
  23. Lee JI. Application of artificial intelligence in gastric cancer. J Dig Cancer Res 2023;11:130-140. https://doi.org/10.52927/jdcr.2023.11.3.130