Animal Bioscience

  • 제37권5호
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  • Pages.952-961
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  • 2024
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Effects of stocking density on the homeostasis of uric acid and related liver and kidney functions in ducks

  • Peiyi Lin (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Sui Liufu (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Jinhui Wang (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Zhanpeng Hou (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Yu Liang (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Haiyue Wang (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Bingxin Li (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Nan Cao (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Wenjun Liu (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Yunmao Huang (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Yunbo Tian (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Danning Xu (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Xiujin Li (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering) ;
  • Xinliang Fu (College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering)
  • 투고 : 2023.09.13
  • 심사 : 2023.12.07
  • 발행 : 2024.05.01
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초록

Objective: Stocking density (SD) is an important issue in the poultry industry, which is related to the production performance, intestinal health and immune status. In the present study, the effects of SD on the metabolism and homeostasis of uric acid as well as the related functions of the liver and kidney in ducks were examined. Methods: A total of 360 healthy 56-day-old Shan-ma ducks were randomly divided into the low stocking density (n = 60, density = 5 birds/m2), medium stocking density (n = 120, density = 10 birds/m2) and high stocking density groups (HSD; n = 180, density = 15 birds/m2). Samples were collected in the 3rd, 6th, and 9th weeks of the experiment for analysis. Results: The serum levels of uric acid, lipopolysaccharide and inflammatory cytokines (interleukin-1β [IL-1β], IL-8, and tumor necrosis factor-α [TNF-α]) were increased significantly in the HSD group. Serious histopathological lesions could be seen in both the livers and kidneys in the HSD group in the 9th week. The mRNA expression levels of inflammatory cytokines (IL-8 and TNF-α) and related pathway components (toll-like receptor 4, myeloid differentiation primary response gene 88, and nuclear factor-κB) were increased significantly in both the livers and kidneys in the HSD group. The mRNA expression levels of enzymes (adenosine deaminase, xanthine oxidase, phosphoribosyl pyrophosphate amidotransferase, and phosphoribosyl pyrophosphate synthetase 1) related to the synthesis of uric acid increased significantly in the livers in the HSD group. However, the mRNA expression level of solute carrier family 2 member 9, which plays an important role in the excretion of uric acid by the kidney, was decreased significantly in the kidneys in the HSD group. Conclusion: These results indicated that a higher SD could cause tissue inflammatory lesions in the liver and kidney and subsequently affect the metabolism and homeostasis of uric acid, and is helpful for guiding decisions related to the breeding and production of ducks.

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과제정보

This research was funded by the Guangdong Basic and Applied Basic Research Foundation (2021A1515111167); Modern Agriculture Waterfowl Industry Technology System Innovation Team of Guangdong (2022KJ137); and the APC was funded by 2021A1515111167.

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