Acknowledgement
This research was supported by the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2021R1A5A1033157).
References
- Gems, D. (2022). The hyperfunction theory: An emerging paradigm for the biology of aging. Ageing Res. Rev. 74, Article 101557.
- Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., and Li, J. (2022). Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct. Target Ther. 7, Article 391.
- Landry, D.A., Yakubovich, E., Cook, D.P., Fasih, S., Upham, J., and Vanderhyden, B.C. (2022). Metformin prevents age-associated ovarian fibrosis by modulating the immune landscape in female mice. Sci. Adv. 8, eabq1475.
- Nambiar, A., Kellogg, D., 3rd, Justice, J., Goros, M., Gelfond, J., Pascual, R., Hashmi, S., Masternak, M., Prata, L., LeBrasseur, N., et al. (2023). Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability. EBioMedicine, 90, Article 104481.
- Pereira, B.I., Devine, O.P., Vukmanovic-Stejic, M., Chambers, E.S., Subramanian, P., Patel, N., Virasami, A., Sebire, N.J., Kinsler, V., Valdovinos, A., et al. (2019). Senescent cells evade immune clearance via HLA-E-mediated NK and CD8(+) T cell inhibition. Nat. Commun. 10, 2387.
- Ryu, W., Park, C.W., Kim, J., Lee, H., and Chung, H. (2023). The Bcl-2/Bcl-xL inhibitor ABT-263 attenuates retinal degeneration by selectively inducing apoptosis in senescent retinal pigment epithelial cells. Mol. Cells, 46, 420-429. https://doi.org/10.14348/molcells.2023.2188
- Shi, D., Liu, W., Gao, Y., Li, X., Huang, Y., Li, X., James, T.D., Guo, Y., and Li, J. (2023). Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging, 3, 297-312. https://doi.org/10.1038/s43587-023-00360-x
- Wang, L., Wang, B., Gasek, N.S., Zhou, Y., Cohn, R.L., Martin, D.E., Zuo, W., Flynn, W.F., Guo, C., Jellison, E.R., et al. (2022). Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 34, 186.
- Wong, F., Omori, S., Donghia, N.M., Zheng, E.J., and Collins, J.J. (2023). Discovering small-molecule senolytics with deep neural networks. Nat. Aging, 3, 734-750. https://doi.org/10.1038/s43587-023-00415-z
- Yang, D., Sun, B., Li, S., Wei, W., Liu, X., Cui, X., Zhang, X., Liu, N., Yan, L., Deng, Y., et al. (2023). NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates. Sci. Transl. Med. 15, eadd1951.