DOI QR코드

DOI QR Code

Mushroom consumption and cardiometabolic health outcomes in the general population: a systematic review

  • Jee Yeon Hong (Department of Preventive Medicine, College of Medicine, Hanyang University) ;
  • Mi Kyung Kim (Department of Preventive Medicine, College of Medicine, Hanyang University) ;
  • Narae Yang (Department of Preventive Medicine, College of Medicine, Hanyang University)
  • 투고 : 2023.09.18
  • 심사 : 2024.03.09
  • 발행 : 2024.04.01

초록

BACKGROUND/OBJECTIVES: Mushroom consumption, rich in diverse nutrients and bioactive compounds, is suggested as a potential significant contributor to preventing cardiometabolic diseases (CMDs). This systematic review aimed to explore the association between mushrooms and cardiometabolic health outcomes, utilizing data from prospective cohort studies and clinical trials focusing on the general population, with mushrooms themselves as a major exposure. SUBJECTS/METHODS: All original articles, published in English until July 2023, were identified through searches on PubMed, Ovid-Embase, and google scholar. Of 1,328 studies, we finally selected 5 prospective cohort studies and 4 clinical trials. RESULTS: Existing research is limited, typically consisting of 1 to 2 studies for each CMD and cardiometabolic condition. Examination of articles revealed suggestive associations in some cardiometabolic conditions including blood glucose (both fasting and postprandial), high-density lipoprotein cholesterol related indices, high-sensitivity C-reactive protein, and obesity indices (body weight, body mass index, and waist circumference). However, mushroom consumption showed no association with the mortality and morbidity of cardiovascular diseases, stroke, and type 2 diabetes, although there was a potentially beneficial connection with all cause-mortality, hyperuricemia, and metabolic syndrome. CONCLUSION: Due to the scarcity of available studies, drawing definitive conclusions is premature. Further comprehensive investigations are needed to clarify the precise nature and extent of this relationship before making conclusive recommendations for the general population.

키워드

참고문헌

  1. de Waard AM, Hollander M, Korevaar JC, Nielen MMJ, Carlsson AC, Lionis C, Seifert B, Thilsing T, de Wit NJ, Schellevis FG, et al. Selective prevention of cardiometabolic diseases: activities and attitudes of general practitioners across Europe. Eur J Public Health 2019;29:88-93. https://doi.org/10.1093/eurpub/cky112
  2. Han Y, Hu Y, Yu C, Guo Y, Pei P, Yang L, Chen Y, Du H, Sun D, Pang Y, et al. Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study. Eur Heart J 2021;42:3374-84. https://doi.org/10.1093/eurheartj/ehab413
  3. Sakakibara BM, Obembe AO, Eng JJ. The prevalence of cardiometabolic multimorbidity and its association with physical activity, diet, and stress in Canada: evidence from a population-based crosssectional study. BMC Public Health 2019;19:1361.
  4. Weigand-Heller AJ, Kris-Etherton PM, Beelman RB. The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. Prev Med 2012;54 Suppl:S75-8. https://doi.org/10.1016/j.ypmed.2011.12.028
  5. Gunawardena D, Bennett L, Shanmugam K, King K, Williams R, Zabaras D, Head R, Ooi L, Gyengesi E, Munch G. Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages. Food Chem 2014;148:92-6. https://doi.org/10.1016/j.foodchem.2013.10.015
  6. Guggenheim AG, Wright KM, Zwickey HL. Immune modulation from five major mushrooms: application to integrative oncology. Integr Med (Encinitas) 2014;13:32-44.
  7. Yoon KN, Lee JS, Kim HY, Lee KR, Shin PG, Cheong JC, Yoo YB, Alam N, Ha TM, Lee TS. Appraisal of antihyperlipidemic activities of Lentinus lepideus in hypercholesterolemic rats. Mycobiology 2011;39:283-9. https://doi.org/10.5941/MYCO.2011.39.4.283
  8. Kirbag S, Akyuz M. Nutritive value of edible wild and cultured mushrooms. Turk J Biol 2010;34:97-102. https://doi.org/10.3906/biy-0805-17
  9. Sahoo S, Gayakwad T, Shahi S. Medicinal value of edible mushrooms: a review. Int J Health Sci (Qassim) 2022;6:8760-7. https://doi.org/10.53730/ijhs.v6nS2.7263
  10. Muszynska B, Grzywacz-Kisielewska A, Kala K, Gdula-Argasinska J. Anti-inflammatory properties of edible mushrooms: a review. Food Chem 2018;243:373-81. https://doi.org/10.1016/j.foodchem.2017.09.149
  11. Yadav D, Negi PS. Bioactive components of mushrooms: Processing effects and health benefits. Food Res Int 2021;148:110599.
  12. Krittanawong C, Isath A, Hahn J, Wang Z, Fogg SE, Bandyopadhyay D, Jneid H, Virani SS, Tang WH. Mushroom consumption and cardiovascular health: a systematic review. Am J Med 2021;134:637-642.e2. https://doi.org/10.1016/j.amjmed.2020.10.035
  13. Uffelman CN, Chan NI, Davis EM, Wang Y, McGowan BS, Campbell WW. An assessment of mushroom consumption on cardiometabolic disease risk factors and morbidities in humans: a systematic review. Nutrients 2023;15:1079.
  14. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009;6:e1000100.
  15. Poddar KH, Ames M, Hsin-Jen C, Feeney MJ, Wang Y, Cheskin LJ. Positive effect of mushrooms substituted for meat on body weight, body composition, and health parameters. A 1-year randomized clinical trial. Appetite 2013;71:379-87. https://doi.org/10.1016/j.appet.2013.09.008
  16. Jayasuriya WJ, Wanigatunge CA, Fernando GH, Abeytunga DT, Suresh TS. Hypoglycaemic activity of culinary Pleurotus ostreatus and P. cystidiosus mushrooms in healthy volunteers and type 2 diabetic patients on diet control and the possible mechanisms of action. Phytother Res 2015;29:303-9. https://doi.org/10.1002/ptr.5255
  17. Harada E, Morizono T, Sumiya T, Kawagishi H. Effect of the medicinal mushroom, Grifola gargal (Agaricomycetes), on bone turnover markers and serum lipids in middle-aged and elderly Japanese women. Int J Med Mushrooms 2016;18:1-7. https://doi.org/10.1615/IntJMedMushrooms.v18.i1.10
  18. Cheraghi Z, Mirmiran P, Mansournia MA, Moslehi N, Khalili D, Nedjat S. The association between nutritional exposures and metabolic syndrome in the Tehran Lipid and Glucose Study (TLGS): a cohort study. Public Health 2016;140:163-71. https://doi.org/10.1016/j.puhe.2016.07.003
  19. Lee DH, Yang M, Giovannucci EL, Sun Q, Chavarro JE. Mushroom consumption, biomarkers, and risk of cardiovascular disease and type 2 diabetes: a prospective cohort study of US women and men. Am J Clin Nutr 2019;110:666-74. https://doi.org/10.1093/ajcn/nqz057
  20. Otsuka R, Tange C, Nishita Y, Kato Y, Tomida M, Imai T, Ando F, Shimokata H. Dietary diversity and all-cause and cause-specific mortality in Japanese community-dwelling older adults. Nutrients 2020;12:1052.
  21. Zhang T, Rayamajhi S, Meng G, Zhang Q, Liu L, Wu H, Gu Y, Wang Y, Zhang S, Wang X, et al. Edible mushroom consumption and incident hyperuricemia: results from the TCLSIH cohort study. Food Funct 2021;12:9178-87. https://doi.org/10.1039/D1FO00650A
  22. Ba DM, Gao X, Muscat J, Al-Shaar L, Chinchilli V, Zhang X, Ssentongo P, Beelman RB, Richie JP Jr. Association of mushroom consumption with all-cause and cause-specific mortality among American adults: prospective cohort study findings from NHANES III. Nutr J 2021;20:38.
  23. Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: a randomized dietary intervention in healthy young adults. J Am Coll Nutr 2015;34:478-87. https://doi.org/10.1080/07315724.2014.950391
  24. Pounis G, Costanzo S, Persichillo M, de Curtis A, Sieri S, Vinceti M, Zito F, Di Castelnuovo AF, Donati MB, de Gaetano G, et al. Mushroom and dietary selenium intakes in relation to fasting glucose levels in a freeliving Italian adult population: the Moli-sani Project. Diabetes Metab 2014;40:34-42. https://doi.org/10.1016/j.diabet.2013.09.007
  25. Food and Agriculture Organization. Total Production of Mushrooms and Truffles Worldwide from 2012 to 2022 (in Million Metric tons)*. New York (NY): Statista; 2023.
  26. SkyQuest Technology. Global Mushroom Market Regional Insights. Sanand: SkyQuest Technology; 2023.
  27. Ba DM, Ssentongo P, Beelman RB, Muscat J, Gao X, Richie JP Jr. Higher mushroom consumption is associated with lower risk of cancer: a systematic review and meta-analysis of observational studies. Adv Nutr 2021;12:1691-704.
  28. Li J, Zou L, Chen W, Zhu B, Shen N, Ke J, Lou J, Song R, Zhong R, Miao X. Dietary mushroom intake may reduce the risk of breast cancer: evidence from a meta-analysis of observational studies. PLoS One 2014;9:e93437.
  29. Shahin L, Patel KM, Heydari MK, Kesselman MM. Hyperuricemia and cardiovascular risk. Cureus 2021;13:e14855.
  30. Li C, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol 2013;25:210-6. https://doi.org/10.1097/BOR.0b013e32835d951e
  31. Jakse B, Jakse B, Pajek M, Pajek J. Uric acid and plant-based nutrition. Nutrients 2019;11:1736.
  32. Yu S, Wu X, Ferguson M, Simmen RC, Cleves MA, Simmen FA, Fang N. Diets containing shiitake mushroom reduce serum lipids and serum lipophilic antioxidant capacity in rats. J Nutr 2016;146:2491-6. https://doi.org/10.3945/jn.116.239806
  33. Petryn TS, Nagalievska MR, Wasser SP, Sybirna NO. Effect of the Lingzi or Reishi medicinal mushroom Ganoderma lucidum (Agaricomycetes) on hyperglycemia and dyslipidemia with experimental metabolic syndrome. Int J Med Mushrooms 2023;25:17-30. https://doi.org/10.1615/IntJMedMushrooms.2023047834
  34. Garcia-Cordero J, Mateos R, Gonzalez-Ramila S, Seguido MA, Sierra-Cinos JL, Sarria B, Bravo L. Dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention. Nutrients 2023;15:2223.
  35. Caussy C, Aubin A, Loomba R. The relationship between type 2 diabetes, NAFLD, and cardiovascular risk. Curr Diab Rep 2021;21:15.
  36. Gallego P, Luque-Sierra A, Falcon G, Carbonero P, Grande L, Bautista JD, Martin F, Del Campo JA. White button mushroom extracts modulate hepatic fibrosis progression, inflammation, and oxidative stress in vitro and in LDLR-/- mice. Foods 2021;10:1788.
  37. Arunachalam K, Sreeja PS, Yang X. The antioxidant properties of mushroom polysaccharides can potentially mitigate oxidative stress, beta-cell dysfunction and insulin resistance. Front Pharmacol 2022;13:874474.
  38. Sima P, Vannucci L, Vetvicka V. β-glucans and cholesterol (review). Int J Mol Med 2018;41:1799-808. https://doi.org/10.3892/ijmm.2018.3411
  39. Feeney MJ, Dwyer J, Hasler-Lewis CM, Milner JA, Noakes M, Rowe S, Wach M, Beelman RB, Caldwell J, Cantorna MT, et al. Mushrooms and Health Summit proceedings. J Nutr 2014;144:1128S-1136S. https://doi.org/10.3945/jn.114.190728