DOI QR코드

DOI QR Code

Patterns of Health-related Quality of Life in Men Who Inject Drugs: A Survey in Southeast Iran

  • Marzieh Nojomi (Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences) ;
  • Maysam Rezapour (Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences) ;
  • Neda Soleimanvandi Azar (Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences) ;
  • Mehdi Darabi (Kermanshah University of Medical Sciences) ;
  • Mehran Asadi-Aliabadi (Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences)
  • 투고 : 2023.08.29
  • 심사 : 2023.12.29
  • 발행 : 2024.03.31

초록

Objectives: Understanding patterns of quality of life in people who inject drugs (PWID) can help healthcare providers plan and manage their health problems in a more focused manner. Therefore, the current study aimed to identify patterns of health-related quality of life in PWID in southeast Iran. Methods: This cross-sectional study was conducted in southeast Iran on men who had injected drugs at least once during the last year. We used convenience sampling in 2 drop-in centers and venue-based sampling at 85 venues. Demographic characteristics, high-risk behaviors, and health-related quality of life were evaluated using the 5-level EQ-5D version (EQ-5D-5L) questionnaire. Latent profile analysis was used to identify patterns of quality of life. Results: This study enrolled 398 PWID, who had a mean age of 34.1±11.4 years. About 47.9% reported a prison history in the last 10 years, 59.2% had injected drugs in the last month, and 31.6% had a history of sharing syringes. About 46.3% reported having 2 or more sexual partners in the last 6 months, and 14.7% had a history of sex with men. Out of the 5 EQ-5D-5L profiles, the fifth profile had the most people (36.6%). Most variations in quality of life were related to pain and discomfort. Conclusions: We showed that the pain and discomfort dimension of EQ-5D-5L had more variation in PWID. This finding will be useful for allocating appropriate interventions and resources to promote health-related quality of life in this population.

키워드

과제정보

The authors would like to thank the Vice-chancellors of Research and Technology at Iran University of Medical Sciences (Tehran, Iran), Iranshahr University of Medical Sciences (Iranshahr, Iran), and all participants in this study.

참고문헌

  1. United Nations Office on Drugs and Crime. Prevalence of drug use; 2020 [cited 2023 Aug 29]. Available from: https://www.unodc.org/unodc/en/data-and-analysis/wdr2021_annex.html
  2. Fauci AS, Folkers GK, Clifford Lane H. Chapter 197: human immunodeficiency virus disease: AIDS and related disorders. In: Kasper DL, Harrison TR, editors. Harrison's principles of internal medicine. 16th ed. New York: McGraw-Hill; 2005, p. 1076-1139.
  3. Grebely J, Larney S, Peacock A, Colledge S, Leung J, Hickman M, et al. Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs. Addiction 2019;114(1):150-166. https://doi.org/10.1111/add.14393
  4. Degenhardt L, Charlson F, Stanaway J, Larney S, Alexander LT, Hickman M, et al. Estimating the burden of disease attributable to injecting drug use as a risk factor for HIV, hepatitis C, and hepatitis B: findings from the Global Burden of Disease Study 2013. Lancet Infect Dis 2016;16(12):1385-1398. https://doi.org/10.1016/S1473-3099(16)30325-5
  5. Des Jarlais DC, Kerr T, Carrieri P, Feelemyer J, Arasteh K. HIV infection among persons who inject drugs: ending old epidemics and addressing new outbreaks. AIDS 2016;30(6):815-826. https://doi.org/10.1097/QAD.0000000000001039
  6. Larney S, Peacock A, Mathers BM, Hickman M, Degenhardt L. A systematic review of injecting-related injury and disease among people who inject drugs. Drug Alcohol Depend 2017;171:39-49. https://doi.org/10.1016/j.drugalcdep.2016.11.029
  7. McCarthy NL, Baggs J, See I, Reddy SC, Jernigan JA, Gokhale RH, et al. Bacterial infections associated with substance use disorders, large cohort of United States hospitals, 2012-2017. Clin Infect Dis 2020;71(7):e37-e44. https://doi.org/10.1093/cid/ciaa008
  8. Mackesy-Amiti ME, Donenberg GR, Ouellet LJ. Prevalence of psychiatric disorders among young injection drug users. Drug Alcohol Depend 2012;124(1-2):70-78. https://doi.org/10.1016/j.drugalcdep.2011.12.012
  9. Mwangi C, Karanja S, Gachohi J, Wanjihia V, Ngang'a Z. Depression, injecting drug use, and risky sexual behavior syndemic among women who inject drugs in Kenya: a cross-sectional survey. Harm Reduct J 2019;16(1):35. https://doi.org/10.1186/s12954-019-0307-5
  10. Williams SC, Davey-Rothwell MA, Tobin KE, Latkin C. People who inject drugs and have mood disorders-a brief assessment of health risk behaviors. Subst Use Misuse 2017;52(9):1181-1190. https://doi.org/10.1080/10826084.2017.1302954
  11. Lemstra M, Rogers M, Thompson A, Moraros J, Buckingham R. Risk indicators of depressive symptomatology among injection drug users and increased HIV risk behaviour. Can J Psychiatry 2011;56(6):358-366. https://doi.org/10.1177/070674371105600607
  12. Nikfarjam A, Shokoohi M, Shahesmaeili A, Haghdoost AA, Baneshi MR, Haji-Maghsoudi S, et al. National population size estimation of illicit drug users through the network scale-up method in 2013 in Iran. Int J Drug Policy 2016;31:147-152. https://doi.org/10.1016/j.drugpo.2016.01.013
  13. Shokoohi M, Karamouzian M, Osooli M, Sharifi H, Fahimfar N, Haghdoost A, et al. Low HIV testing rate and its correlates among men who inject drugs in Iran. Int J Drug Policy 2016;32:64-69. https://doi.org/10.1016/j.drugpo.2016.03.009
  14. Rahimi J, Gholami J, Amin-Esmaeili M, Fotouhi A, Rafiemanesh H, Shadloo B, et al. HIV prevalence among people who inject drugs (PWID) and related factors in Iran: a systematic review, meta-analysis and trend analysis. Addiction 2020;115(4):605-622. https://doi.org/10.1111/add.14853
  15. World Health Organization. Health topics: HIV/AIDS: 2020 [cited 2023 Jul 4]. Available from: https://www.who.int/europe/health-topics
  16. Sharifi H, Mirzazadeh A, Shokoohi M, Karamouzian M, Khajehkazemi R, Navadeh S, et al. Estimation of HIV incidence and its trend in three key populations in Iran. PLoS One 2018;13(11):e0207681. https://doi.org/10.1371/journal.pone.0207681
  17. Tran BX, Nguyen LH, Nong VM, Nguyen CT, Phan HT, Latkin CA. Behavioral and quality-of-life outcomes in different service models for methadone maintenance treatment in Vietnam. Harm Reduct J 2016;13:4. https://doi.org/10.1186/s12954-016-0091-4
  18. Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? Pharmacoeconomics 2016;34(7):645-649. https://doi.org/10.1007/s40273-016-0389-9
  19. Huang J, Zhu J, Ruan Y, Zhou H, Guo W, Dong A. Health-related quality of life in Chinese medical staff: a latent profile analysis. Front Public Health 2023;11:1183483. https://doi.org/10.3389/fpubh.2023.1183483
  20. Pinheiro LC, Tan X, Olshan AF, Wheeler SB, Reeder-Hayes KE, Samuel CA, et al. Examining health-related quality of life patterns in women with breast cancer. Qual Life Res 2017;26(7):1733-1743. https://doi.org/10.1007/s11136-017-1533-5
  21. Cheng Q, Bajis S, Cunningham E, Shih ST, Schulz M, Marshall AD, et al. Health-related quality of life among people who inject drugs in Australia. Qual Life Res 2023;32(11):3195-3207. https://doi.org/10.1007/s11136-023-03465-3
  22. Wikipedia. Iranshahr, Iran [cited 2023 Jul 18]. Available from: https://en.wikipedia.org/wiki/Iranshahr,_Iran
  23. Devlin N, Parkin D, Janssen B. An introduction to EQ-5D instruments and their applications. In: Devlin N, Parkin D, Janssen B, editors. Methods for analysing and reporting EQ-5D data. Cham: Springer; 2020. https://doi.org/10.1007/978-3-030-47622-9
  24. Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res 2011;20(10):1727-1736. https://doi.org/10.1007/s11136-011-9903-x
  25. Schwarz G. Estimating the dimension of a model. Ann Stat 1978;6(2):461-464. https://doi.org/10.1214/aos/1176344136
  26. Sclove SL. Application of model-selection criteria to some problems in multivariate analysis. Psychometrika 1987;52:333-343. https://doi.org/10.1007/BF02294360
  27. Nylund KL, Asparouhov T, Muthen BO. Deciding on the number of classes in latent class analysis and growth mixture modeling: a Monte Carlo simulation study. Struct Equ Modeling 2007;14(4):535-569. https://doi.org/10.1080/10705510701575396
  28. Armstrong G, Nuken A, Samson L, Singh S, Jorm AF, Kermode M. Quality of life, depression, anxiety and suicidal ideation among men who inject drugs in Delhi, India. BMC Psychiatry 2013;13:151. https://doi.org/10.1186/1471-244X-13-151
  29. Roshanfekr P, Khezri M, Karimi SE, Vameghi M, Ali D, Ahmadi S, et al. Lifetime and past-month substance use and injection among street-based female sex workers in Iran. Harm Reduct J 2021;18(1):33. https://doi.org/10.1186/s12954-021-00477-5
  30. Vasylyev M, Davtyan H, Denisiuk O, Chadwick Jayaraj J, Koval T, Piddubna A, et al. Anxiety, depression, and quality of life among HIV positive injection drug users in Ukraine, 2017. J Infect Dev Ctries 2019;13(7.1):111S-117S. https://doi.org/10.3855/jidc.11295
  31. Bielinska A, Wa Z P, Bielinska-Wa Z D. A computational model of similarity analysis in quality of life research: an example of studies in Poland. Life (Basel) 2022;12(1):56. https://doi.org/10.3390/life12010056
  32. Korthuis PT, Zephyrin LC, Fleishman JA, Saha S, Josephs JS, McGrath MM, et al. Health-related quality of life in HIV-infected patients: the role of substance use. AIDS Patient Care STDS 2008;22(11):859-867. https://doi.org/10.1089/apc.2008.0005
  33. Nikoo Seresht Z, Rimaz S, Nedjat S, Motevallian SA, Saeepour N. The relationship between quality of life and social capital amongst people living with HIV/AIDS attending the Imam Khomeini hospital consultation center for clients with risky behaviors in Tehran-2011. J Sch Public Health Inst Public Health Res 2011;11(3):17-28 (Persian).
  34. Yen YF, Chou P, Lin YS, Deng CY. Factors associated with health-related quality of life among injection drug users at methadone clinics in Taipei, Taiwan. J Chin Med Assoc 2015;78(5):292-298. https://doi.org/10.1016/j.jcma.2015.01.001
  35. Preau M, Protopopescu C, Spire B, Sobel A, Dellamonica P, Moatti JP, et al. Health related quality of life among both current and former injection drug users who are HIV-infected. Drug Alcohol Depend 2007;86(2-3):175-182. https://doi.org/10.1016/j.drugalcdep.2006.06.012
  36. Fischer JA, Conrad S, Clavarino AM, Kemp R, Najman JM. Quality of life of people who inject drugs: characteristics and comparisons with other population samples. Qual Life Res 2013;22(8):2113-2121. https://doi.org/10.1007/s11136-013-0350-8
  37. Costenbader EC, Zule WA, Coomes CM. The impact of illicit drug use and harmful drinking on quality of life among injection drug users at high risk for hepatitis C infection. Drug Alcohol Depend 2007;89(2-3):251-258. https://doi.org/10.1016/j.drugalcdep.2007.01.006