대한수의학회지 (Korean Journal of Veterinary Research)

  • 제64권1호
  • /
  • Pages.4.1-4.5
  • /
  • 2024
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Notable mutations of porcine parvovirus 1 and 4 circulating in commercial pig farms in South Korea

  • Beomsu Park (College of Veterinary Medicine, Konkuk University) ;
  • Jihyeon Hong (College of Veterinary Medicine, Konkuk University) ;
  • Jongsu Jun (College of Veterinary Medicine, Konkuk University) ;
  • An Kook Choi (College of Veterinary Medicine, Konkuk University) ;
  • Choi Kyu Park (College of Veterinary Medicine, Kyungpook National University) ;
  • Young Soo Lyoo (College of Veterinary Medicine, Konkuk University)
  • 투고 : 2023.09.05
  • 심사 : 2024.02.23
  • 발행 : 2024.03.31
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초록

In this study, almost complete genomic sequences of porcine parvovirus (PPV)1 and PPV4 circulating in commercial pig farms in South Korea were obtained and analyzed. Important mutations that may be precursors to host changes, such as premature stop codons of PPV1 and frameshift mutations of PPV4, were observed in these sequences. A 27a-like strain of PPV1, known to show a lack of cross- neutralization against existing commercial vaccine strains, was identified by phylogenetic analysis. Given the active genetic evolution, the additional precursors to host changes and emerging new genotypes of PPVs need to be monitored through continuous sampling and genetic analysis.

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과제정보

This study was supported by Konkuk University's research support program for its faculty on sabbatical leave in 2022.

참고문헌

  1. Cotmore SF, Agbandje-McKenna M, Chiorini JA, Mukha DV, Pintel DJ, Qiu J, Soderlund-Venermo M, Tattersall P, Tijssen P, Gatherer D, Davison AJ. The family Parvoviridae. Arch Virol 2014;159:1239-1247. 
  2. Streck AF, Truyen U. Porcine parvovirus. Curr Issues Mol Biol 2020;37:33-46. 
  3. Meszaros I, Olasz F, Csagola A, Tijssen P, Zadori Z. Biology of porcine parvovirus (ungulate parvovirus 1). Viruses 2017;9:393. 
  4. Zeeuw EJL, Leinecker N, Herwig V, Selbitz HJ, Truyen U. Study of the virulence and cross-neutralization capability of recent porcine parvovirus field isolates and vaccine viruses in experimentally infected pregnant gilts. J Gen Virol 2007;88(Pt 2):420-427. 
  5. Cheung AK, Wu G, Wang D, Bayles DO, Lager KM, Vincent AL. Identification and molecular cloning of a novel porcine parvovirus. Arch Virol 2010;155:801-806. 
  6. Parrish CR, Kawaoka Y. The origins of new pandemic viruses: the acquisition of new host ranges by canine parvovirus and influenza A viruses. Annu Rev Microbiol 2005;59:553-586. 
  7. Lee H, Callaway HM, Cifuente JO, Bator CM, Parrish CR, Hafenstein SL. Transferrin receptor binds virus capsid with dynamic motion. Proc Natl Acad Sci U S A 2019;116:20462-20471. 
  8. Ma W, Kahn RE, Richt JA. The pig as a mixing vessel for influenza viruses: human and veterinary implications. J Mol Genet Med 2008;3:158-166. 
  9. Kim SC, Jeong CG, Nazki S, Lee SI, Baek YC, Jung YJ, Kim WI. Evaluation of a multiplex PCR method for the detection of porcine parvovirus types 1 through 7 using various field samples. PLoS One 2021;16:e0245699. 
  10. Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 2004;32:1792-1797. 
  11. Guindon S, Gascuel O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 2003;52:696-704. 
  12. Zimmermann P, Ritzmann M, Selbitz HJ, Heinritzi K, Truyen U. VP1 sequences of German porcine parvovirus isolates define two genetic lineages. J Gen Virol 2006;87(Pt 2):295-301. 
  13. Simpson AA, Hebert B, Sullivan GM, Parrish CR, Zadori Z, Tijssen P, Rossmann MG. The structure of porcine parvovirus: comparison with related viruses. J Mol Biol 2002;315:1189-1198. 
  14. Yoo SJ, Sunwoo SY, Ko SS, Je SH, Lee DU, Lyoo YS. A novel porcine bocavirus harbors a variant NP gene. Springerplus 2015;4:370. 
  15. Streck AF, Canal CW, Truyen U. Viral fitness and antigenic determinants of porcine parvovirus at the amino acid level of the capsid protein. J Virol 2022;96:e0119821. 
  16. Ji YF, Shao JW, Chen RX, Gong HY, Sun MH, Li GH, Chen JM. Frameshift mutations in the microevolution and macroevolution of viruses [Preprint]. Posted 2022 Jul 20. bioRxiv. https://doi.org/10.1101/2022.07.20.500745. 
  17. Cadar D, Csagola A, Lorincz M, Tombacz K, Kiss T, Spinu M, Tuboly T. Genetic detection and analysis of porcine bocavirus type 1 (PoBoV1) in European wild boar (Sus scrofa). Virus Genes 2011;43:376-379.