한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제47권1호
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  • Pages.9-17
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  • 2024
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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전북지역 돼지유행성설사 바이러스 Spike 유전자분석

Sequence analysis of spike genes of porcine epidemic diarrhea virus (PEDV) from Jeonbuk province

  • Mi Seon Kang (Jeollabuk-do Institute of Livestock & Veterinary Research) ;
  • Woo Ri Jung (Jeollabuk-do Institute of Livestock & Veterinary Research) ;
  • Seung Hyuck Yang (Jeollabuk-do Institute of Livestock & Veterinary Research) ;
  • Keum Suk Chu (Jeollabuk-do Institute of Livestock & Veterinary Research)
  • 투고 : 2023.11.23
  • 심사 : 2024.01.23
  • 발행 : 2024.03.30
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초록

Porcine epidemic diarrhea (PED) is a highly contagious enteric viral disease of pigs with watery diarrhea in piglets, which ultimately results in huge economic losses in the swine industry. The spike (S) protein plays an important role in viral pathogenicity, tissue tropism, infection, dissemination and the trypsin-dependent proliferation of the PED virus (PEDV). In the present study, we determined the full-length spike (S) gene sequences of twenty PEDV field strains detected in Jeonbuk province in 2022. Phylogenetic analysis showed that the twenty PEDV field strains were classified into G2b group and shared 98.6~100% of nucleotide homology and 97.4~100% of amino acid homology with each other. Mutations of amino acid sequences on the neutralizing epitope of S protein were observed in the twenty field strains compared to the previous vaccine strain SM-98-1 (G1a group). Therefore, these amino acid mutations in the PEDV S protein may result in a new genotype of the virus and highly pathogenic virus, so continuous monitoring is required.

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참고문헌

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