한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제37권1호
  • /
  • Pages.1-8
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  • 2024
  • /
  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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Dextran Sodium Sulfate 유발 마우스 대장염에서 Lactiplantibacillus plantarum JSA22 쌀 발효물의 효과

Effect of Lactiplantibacillus plantarum JSA22-fermented Rice Drinks against Dextran Sodium Sulfate-induced Colitis in Mice

  • 유지송 (원광대학교 의과대학 생리학교실 ) ;
  • 선다현 (원광대학교 의과대학 생리학교실 ) ;
  • 최현석 (원광대학교 의과대학 생리학교실 ) ;
  • 김민섭 (원광대학교 의과대학 생리학교실 ) ;
  • 유명환 (원광대학교 의과대학 생리학교실 ) ;
  • 진종식 (전북대학교 한약자원학과) ;
  • 김동근 (전북대학교 한약자원학과 ) ;
  • 최혜선 (농촌진흥청 ) ;
  • 박정호 (강북삼성병원 소화기내과) ;
  • 김용성 (주식회사 것앤드푸드헬스케어 ) ;
  • 이문영 (원광대학교 의과대학 생리학교실)
  • Jisong You (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine) ;
  • Dahyun Seon (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine) ;
  • Hyun Seok Choi (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine) ;
  • Min Seob Kim (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine) ;
  • Myeong Hwan Yu (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine) ;
  • Jong Sik Jin (Dept. of Oriental Medicine Resources, Jeonbuk National University) ;
  • Dong Keun Kim (Dept. of Oriental Medicine Resources, Jeonbuk National University) ;
  • Hye Sun Choi (National Institute of Crop Science, Rural Development Administration) ;
  • Jung Ho Park (Dept. of Gastroenterology, Kangbuk Samsung Hospital) ;
  • Yong Sung Kim (Gut & Food Healthcare Co., Ltd.) ;
  • Moon Young Lee (Dept. of Physiology, Digestive Disease Research Institute, Wonkwang University School of Medicine)
  • 투고 : 2023.11.15
  • 심사 : 2024.01.15
  • 발행 : 2024.02.28
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초록

This study investigated the effect of Lactiplantibacillus plantarum JSA22-fermented rice drinks on dextran sodium sulfate (DSS)-induced colitis in mice. Twenty-four mice were randomly assigned; No colitis (Con), colitis with tap water (DSS-only), colitis with unfermented rice (DSS-UFR), and colitis with fermented rice (DSS-FR). After inducing colitis with 2% DSS for 5 days, they were given Tap water, UFR drink, or FR drink for an additional 6 days. The DSS-FR group had significantly lower Disease Activity Index (DAI) scores compared to the DSS-only group, but no significant difference with the DSS-UFR group. Colon length was reduced in the DSS-only group. The DSS-only group had significantly higher IL-6 mRNA levels compared to the Con group, while the DSS-FR groups showed significantly lower IL-6 mRNA levels compared to the DSS-only group. These results suggest that rice drinks fermented with Lactiplantibacillus Plantarum JSA22 ameliorate the severity of DSS-colitis, by potentially reducing proinflammatory cytokines.

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과제정보

본 논문은 농촌진흥청 연구개발사업(PJ016707)으로 수행된 결과입니다.

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