Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Therapeutic Dose, Duration, and Efficacy of Bee Venom for Treating Clinical Mastitis in Dairy Cow

  • Seong-Min Kim (Laboratory of Veterinary Theriogenology, College of Veterinary Medicine, Chungbuk National University) ;
  • Kyung-Duk Min (Laboratory of Veterinary Theriogenology, College of Veterinary Medicine, Chungbuk National University) ;
  • Seon-Jong Yun (Veterinary Pharmaceutical Management Division, Animal and Plant Quarantine Agency) ;
  • Dae-Youn Hwang (Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University) ;
  • Hyun-Gu Kang (Laboratory of Veterinary Theriogenology, College of Veterinary Medicine, Chungbuk National University)
  • Received : 2024.01.23
  • Accepted : 2024.01.29
  • Published : 2024.02.28
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Abstract

This study was conducted to explore the efficacy of bee venom as a treatment for mastitis and to determine the optimal dosage and treatment period. When 6 mg or 12 mg of bee venom was administered to each experimental quarter of mastitis in dairy cow, the clinical symptoms in the 12 mg quarter were noticeably improved compared to those in the 6 mg quarter. There was no significant difference in the somatic cell count (SCC) in the milk between normal and mastitis quarters between the 6 and 12 mg doses, but there was a steady decrease in the 12 mg-treated quarter (p = 0.34). To determine the treatment period, bee venom was administered for 2, 4, and 7 days. After administering 12 mg of bee venom for 7 days, the SCC in the milk was compared before 6 days and after 7 days, and the SCC was significantly decreased to less than 100,000 SC/mL after 7 days (p = 0.01). In addition, to investigate the efficacy of bee venom, the minimum inhibitory concentration for S. aureus, E. coli, and coagulase negative staphylococci was measured, and the results showed that Gram-positive bacteria were more sensitive to bee venom than Gram-negative bacteria, and treatment for Gram-negative bacteria was limited. As a result of this study, it was confirmed that a dose of 12 mg of bee venom and a treatment period of more than 7 days were required to treat mastitis, and that treatment with bee venom alone against Gram-negative bacteria was negative.

Keywords

References

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