The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Current Trends of Traditional Herbal Medicine Research on Allergic Disease with Dysbiosis

알레르기 질환에서 장내미생물 조절을 통한 한약의 효과 연구동향

  • Yun-Jung Lee (Dep. of Clinical Korean Medicine, College of Korean Medicine, Graduate school, Kyung Hee University) ;
  • Min-Hee Kim (Dep. of Ophthalmology, Otolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
  • 이윤정 (경희대학교 대학원 한의과대학 임상한의학과) ;
  • 김민희 (경희대학교 한의과대학 안이비인후피부과)
  • Received : 2024.01.07
  • Accepted : 2024.01.31
  • Published : 2024.02.25
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Abstract

Objectives : The purpose of this study is to analyze the current trends of various herbal medicine research on allergic disease with dysbiosis. Methods : Electronic searches were performed using Pubmed, Research Information Sharing Service(RISS), Korean studies Information Service System(KISS), Oriental medicine Advanced Searching Integrated System(OASIS). Results : We analyzed ten studies on the effect of herbal medicine on allergic disease with dysbiosis. Eight studies were animal experimental studies, and two were randomized clinical trial(RCT) study and one-group pretest-posttest research, respectively. Among the studies, three studies were on atopic dermatitis, two on allergic rhinitis, and five on asthma. All different herbal medicines were used in the studies. Changes in gut microbiota composition were observed in nine studies except for 1 RCT study. In eight animal experimental studies, there was significant reduction in allergy-related inflammatory markers. Six studies evaluated the change of metabolites related to gut microbiota and three of them showed significant increase in short-chain fatty acids(SCFA). Conclusion : This study provides current trends of studies on herbal medicine research on allergic disease with dysbiosis. Most research is conducted using animal experiments, and this is a relatively recent trend. These studies offer basic knowledge on the correlation between herbal medicine, gut microbiota, and anti-inflammatory effects in allergic disease.

Keywords

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