Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study

  • Andi Tajrin (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • M. Ruslin (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Muh. Irfan Rasul (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Nurwahida (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Hadira (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Husni Mubarak (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Katharina Oginawati (Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung) ;
  • Nurul Fahimah (Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung) ;
  • Ikeu Tanziha (Department of Community Nutrition, Faculty of Human Ecology, Bogor Institute of Agriculture) ;
  • Annisa Dwi Damayanti (Department of Environmental Engineering, Faculty of Engineering, Hasanuddin University) ;
  • Utriweni Mukhaiyar (Statistics Research Division, Institut Teknologi Bandung) ;
  • Asri Arumsari (Departement Oral and Maxillofacial Surgery, RSUP Dr Hasan Sadikin, Faculty of Dentistry, Padjajaran University Bandung) ;
  • Ida Ayu Astuti (Department of Oral and Maxillofacial Surgery, Padjadjaran University) ;
  • Farah Asnely Putri (Department of Oral and Maxillofacial Surgery, Padjadjaran University) ;
  • Shinta Silvia (Department of Environmental Engineering, Faculty of Engineering, Andalas University)
  • Received : 2023.10.16
  • Accepted : 2024.02.16
  • Published : 2024.02.20
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Abstract

Background: The pathogenesis of orofacial cleft (OFC) is multifactorial, involving both genetic and non-genetic factors, the latter of which play a key role in the development of these anomalies. This paper addresses the incidence of OFC in Indonesia, with a focus on identifying and examining the distribution of contributory factors, including parental medical history, pregnancy history, and environmental influences. Methods: The study was conducted through the collection of primary data. An interdisciplinary research team from Indonesia administered a standardized questionnaire to parents who had children with OFC and who had provided informed consent. The case group comprised 133 children born with cleft lip and/or palate, and the control was 133 noncleft children born full-term. The risk factors associated with OFC anomalies were analyzed using the chi-square test and logistic regression. All statistical analyses were performed using SPSS version 25. A p-value of 0.05 or less was considered to indicate statistical significance. Results: The study comprised 138 children, of whom 82 were boys (59.4%) and 56 were girls (40.6%). Among them, 45 patients (32.6%) presented with both cleft lip and cleft palate, 25 individuals (18.1%) had a cleft palate only, and 28 patients (20.3%) had a cleft lip only. OFC was found to be significantly associated with a maternal family history of congenital birth defects (p<0.05), complications during the first trimester (p<0.05), consumption of local fish (p<0.05), caffeine intake (p<0.05), prolonged medication use (p<0.05), immunization history (p<0.05), passive smoking (p<0.05), and X-ray exposure during pregnancy (p<0.05). Conclusion: The findings indicate close relationships between the incidence of OFC and maternal medical history, prenatal factors, and environmental influences.

Keywords

References

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