Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives

  • Fazila Sirajudeen (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Lara J. Bou Malhab (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Yasser Bustanji (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Moyad Shahwan (Centre of Medical and Bio-allied Health Sciences Research, Ajman University) ;
  • Karem H. Alzoubi (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Mohammad H. Semreen (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Jalal Taneera (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Waseem El-Huneidi (Research Institute for Medical and Health Sciences, University of Sharjah) ;
  • Eman Abu-Gharbieh (Research Institute for Medical and Health Sciences, University of Sharjah)
  • Received : 2023.03.13
  • Accepted : 2023.06.26
  • Published : 2024.01.01
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Abstract

Cancer is a global health challenge with high morbidity and mortality rates. However, conventional cancer treatment methods often have severe side effects and limited success rates. In the last decade, extensive research has been conducted to develop safe, and efficient alternative treatments that do not have the limitations of existing anticancer medicines. Plant-derived compounds have shown promise in cancer treatment for their anti-carcinogenic and anti-proliferative properties. Rosmarinic acid (RA) and carnosic acid (CA) are potent polyphenolic compounds found in rosemary (Rosmarinus officinalis) extract. They have been extensively studied for their biological properties, which include anti-diabetic, anti-inflammatory, antioxidant, and anticancer activities. In addition, RA and CA have demonstrated effective anti-proliferative properties against various cancers, making them promising targets for extensive research to develop candidate or leading compounds for cancer treatment. This review discusses and summarizes the anti-tumor effect of RA and CA against various cancers and highlights the involved biochemical and mechanistic pathways.

Keywords

Acknowledgement

The research was supported by a grant from the College of Research and Graduate Studies at the University of Sharjah (No.2001090185) and grant (No.2001090271).

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