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Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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A Randomized Trial Comparing the Effect of Unani Formulation with Metronidazole in Bacterial Vaginosis

  • Nazia Usmoni (Department of Niswan wa Qabalat, Luqman Unani, Medical College, Hospital and Research Centre) ;
  • Mariyam Roqaiya (Department of Niswan wa Qabalat, State Takmeel-ut-Tib College) ;
  • Mohd Aqil Quadri (Department of Niswan wa Qabalat, National Institute of Unani Medicine) ;
  • Arshiya Sultana (Department of Niswan wa Qabalat, National Institute of Unani Medicine) ;
  • Taseen Banu (GPHC) ;
  • Sumbul Alam (Department of Niswan wa Qabalat, State Takmeel-ut-Tib College)
  • Received : 2023.09.26
  • Accepted : 2023.11.22
  • Published : 2023.11.30
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Abstract

Background and objectives: Bacterial vaginosis (BV) is recognized as the most prevalent type of vaginal infection, impacting approximately 19-24% of women in their reproductive years. The recurrence rate of BV is significant, negatively impacting the well-being of affected women. This study aimed to compare the therapeutic effects of a polyherbal Unani formulation and metronidazole in treating bacterial vaginosis. Methodology: In this prospective patient blinded standard controlled trial, a total of 40 individuals with a clinical diagnosis of bacterial vaginosis were randomly assigned to receive either an active control treatment (n = 20) or a test drug (n = 20). In the test drug combination of Acacia catechu, Azadirachta indica and Quercus infectoria in tablet (1g) form in the dose of 2 tablets orally twice daily with water was administered for 3 weeks. In the active control standard drug, metronidazole 400 mg tablet, orally twice daily was given for one week. The primary outcome measure was clinical cure; H. negative Amsel's criteria and a reduction in subjective symptoms, while the secondary outcome measure was an improvement in SF-36 quality of life (QOL). Results and conclusion: Both the experimental treatment and the metronidazole demonstrated a significant clinical cure for bacterial vaginosis as well as an increase in health-related quality of life. Based on these findings, it appears that the test medication is a potent Unani formulation for the treatment of bacterial vaginosis. A well conducted trial with a bigger sample size is required to corroborate these findings.

Keywords

Acknowledgement

Authors are very much thankful to the management of this institute for providing all the infrastructures required for this study.

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