Journal of Veterinary Science

  • 제24권6호
  • /
  • Pages.86.1-86.14
  • /
  • 2023
  • /
  • 1229-845X(pISSN)
  • /
  • 1976-555X(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지
DOI QR코드

DOI QR Code

Comparison of the outcomes of phacoemulsification versus topical medication alone in canine diabetic cataracts: a retrospective study

  • Eunji Lee (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Seonmi Kang (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Seonmi Kang (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University) ;
  • Kangmoon Seo (Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University)
  • 투고 : 2023.06.21
  • 심사 : 2023.10.18
  • 발행 : 2023.11.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Long-term comparisons of phacoemulsification with topical medication are limited in canine diabetic cataracts. Objectives: To compare outcomes of eyes submitted to phacoemulsification with those of topical medication for canine diabetic cataracts and identify risk factors for complications. Methods: Through medical records review, 150 eyes (76 dogs) with diabetic cataracts were included; 58 eyes (31 dogs) underwent phacoemulsification (phaco-group) and 92 eyes (48 dogs) received ophthalmic solution alone (medication-group). The medication-group was divided into owner-led and vet-led groups depending on who elected not to perform surgery. Comparisons involved time-to-complications, vision, and the number and type of ophthalmic solutions administered. The association between complications and pretreatment clinical findings was investigated. Results: No difference was found in complication risk between the phaco and owner-led medication groups. Conversely, the vet-led medication-group had a higher complication risk than the other groups. At the last follow-up, 94.8% of the phaco-group had vision, whereas 7.6% of the medication-group restored some visual axis. Poor glycemic control in the medication-group and younger age in the phaco-group increased complication risk. At 1-year post-treatment, the average number of ophthalmic solutions administered was 1.7 and 2.6 in the phaco and medication groups, respectively. The medication-group used anti-inflammatories the most throughout the follow-up, whereas the phaco-group used anti-inflammatories the most until 1-year post-treatment and lacrimostimulants at 1.5-year post-treatment. Conclusions: For canine diabetic cataracts, phacoemulsification is recommended because it is superior to topical management alone in terms of maintaining vision and reducing the number of ophthalmic solutions required in the long term.

키워드

과제정보

This study was supported by the BK21 FOUR Future Veterinary Medicine Leading Education, Research Center and the Research Institute for Veterinary Science (RIVS), College of Veterinary Medicine, Seoul National University, and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1I1A1A01058695).

참고문헌

  1. Nelson RW. Canine diabetes mellitus. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, editors. Canine and Feline Endocrinology. 4th ed. Saint Louis: Saunders Elsevier; 2015, 213-253.
  2. Basher AW, Roberts SM. Ocular manifestations of diabetes mellitus: diabetic cataracts in dogs. Vet Clin North Am Small Anim Pract. 1995;25(3):661-676. https://doi.org/10.1016/S0195-5616(95)50061-0
  3. Kador PF, Webb TR, Bras D, Ketring K, Wyman M. Topical KINOSTATTM ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus. Vet Ophthalmol. 2010;13(6):363-368. https://doi.org/10.1111/j.1463-5224.2010.00826.x
  4. Leiva M, Pena T. Disease of the lens and cataract formation. In: Gelatt KN, Ben-Shlomo G, Gilger BC, Hendrix DVH, Kern TJ, Plummer CE, editors. Veterinary Ophthalmology. 6th ed. Hoboken: John Wiley & Sons; 2021, 1317-1358.
  5. Bagley LH 2nd, Lavach JD. Comparison of postoperative phacoemulsification results in dogs with and without diabetes mellitus: 153 cases (1991-1992). J Am Vet Med Assoc. 1994;205(8):1165-1169. https://doi.org/10.2460/javma.1994.205.08.1165
  6. Klein HE, Krohne SG, Moore GE, Stiles J. Postoperative complications and visual outcomes of phacoemulsification in 103 dogs (179 eyes): 2006-2008. Vet Ophthalmol. 2011;14(2):114-120. https://doi.org/10.1111/j.1463-5224.2010.00853.x
  7. Sigle KJ, Nasisse MP. Long-term complications after phacoemulsification for cataract removal in dogs: 172 cases (1995-2002). J Am Vet Med Assoc. 2006;228(1):74-79. https://doi.org/10.2460/javma.228.1.74
  8. Kronen P, Moon-Massat PF, Ludders JW, Gleed RD, Kern TJ, Randolph J, et al. Comparison of two insulin protocols for diabetic dogs undergoing cataract surgery. Vet Anaesth Analg. 2001;28(3):146-155. https://doi.org/10.1046/j.1467-2987.2001.00053.x
  9. Appel SL, Maggs DJ, Hollingsworth SR, Kass PH. Evaluation of client perceptions concerning outcome of cataract surgery in dogs. J Am Vet Med Assoc. 2006;228(6):870-875. https://doi.org/10.2460/javma.228.6.870
  10. Oliver JA, Clark L, Corletto F, Gould DJ, Gould DJ. A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study. Vet Ophthalmol. 2010;13(4):244-250. https://doi.org/10.1111/j.1463-5224.2010.00793.x
  11. Niessen SJ, Powney S, Guitian J, Niessen AP, Pion PD, Shaw JA, et al. Evaluation of a quality-of-life tool for dogs with diabetes mellitus. J Vet Intern Med. 2012;26(4):953-961. https://doi.org/10.1111/j.1939-1676.2012.00947.x
  12. Aptekmann KP, Schwartz DS. A survey of owner attitudes and experiences in managing diabetic dogs. Vet J. 2011;190(2):e122-e124. https://doi.org/10.1016/j.tvjl.2011.02.007
  13. Krishnan H, Hetzel S, McLellan GJ, Bentley E. Comparison of outcomes in cataractous eyes of dogs undergoing phacoemulsification versus eyes not undergoing surgery. Vet Ophthalmol. 2020;23(2):286-291. https://doi.org/10.1111/vop.12724
  14. Lim CC, Bakker SC, Waldner CL, Sandmeyer LS, Grahn BH. Cataracts in 44 dogs (77 eyes): a comparison of outcomes for no treatment, topical medical management, or phacoemulsification with intraocular lens implantation. Can Vet J. 2011;52(3):283-288.
  15. Wilkie DA, Gemensky-Metzler AJ, Colitz CM, Bras ID, Kuonen VJ, Norris KN, et al. Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18 dogs. Vet Ophthalmol. 2006;9(5):328-334. https://doi.org/10.1111/j.1463-5224.2006.00490.x
  16. Miller EJ, Brines CM. Canine diabetes mellitus associated ocular disease. Top Companion Anim Med. 2018;33(1):29-34. https://doi.org/10.1053/j.tcam.2018.03.001
  17. Pirie CG, Shelnutt LM, Langlois DK. Assessment of iris vasculature abnormalities in dogs with diabetes mellitus. Am J Vet Res. 2021;82(10):829-839. https://doi.org/10.2460/ajvr.82.10.829
  18. Zibura AE, Robertson JB, Westermeyer HD. Gonioscopic iridocorneal angle morphology and incidence of postoperative ocular hypertension and glaucoma in dogs following cataract surgery. Vet Ophthalmol. 2021;24 Suppl 1:50-62. https://doi.org/10.1111/vop.12802
  19. Hogan MJ, Kimura SJ, Thygeson P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959;47(5 Pt 2):155-170. https://doi.org/10.1016/S0002-9394(14)78239-X
  20. Pumphrey S. Canine secondary glaucomas. Vet Clin North Am Small Anim Pract. 2015;45(6):1335-1364. https://doi.org/10.1016/j.cvsm.2015.06.009
  21. Johnsen DA, Maggs DJ, Kass PH. Evaluation of risk factors for development of secondary glaucoma in dogs: 156 cases (1999-2004). J Am Vet Med Assoc. 2006;229(8):1270-1274. https://doi.org/10.2460/javma.229.8.1270
  22. Gelatt KN, MacKay EO. Secondary glaucomas in the dog in North America. Vet Ophthalmol. 2004;7(4):245-259. https://doi.org/10.1111/j.1463-5224.2004.04034.x
  23. Plummer CE, Komaromy AM, Gelatt KN. The canine glaucomas. In: Gelatt KN, Ben-Shlomo G, Gilger BC, Hendrix DVH, Kern TJ, Plummer CE, editors. Veterinary Ophthalmology. 6th ed. Hoboken: John Wiley & Sons; 2021, 1173-1240.
  24. Williams DL. Lens morphometry determined by B-mode ultrasonography of the normal and cataractous canine lens. Vet Ophthalmol. 2004;7(2):91-95. https://doi.org/10.1111/j.1463-5224.2004.04005.x
  25. Anthrayose CV, Shashidhar S. Studies on protein and taurine in normal, senile and diabetic cataractous human lenses. Indian J Physiol Pharmacol. 2004;48(3):357-360.
  26. Di Girolamo N, Verma MJ, McCluskey PJ, Lloyd A, Wakefield D. Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis. Curr Eye Res. 1996;15(10):1060-1068. https://doi.org/10.3109/02713689609017656
  27. Monteiro TP, Estrela Silva SE, Domingues M, Fernandes AV, Falcao-Reis F. Complete spontaneous posterior luxation of capsular bag-intraocular lens-capsular tension ring complex. J Cataract Refract Surg. 2009;35(12):2154-2156. https://doi.org/10.1016/j.jcrs.2009.05.062
  28. Zech JC, Tanniere P, Denis P, Trepsat C. Posterior chamber intraocular lens dislocation with the bag. J Cataract Refract Surg. 1999;25(8):1168-1169. https://doi.org/10.1016/S0886-3350(99)00124-8
  29. Fischer MC, Meyer-Lindenberg A. Progression and complications of canine cataracts for different stages of development and aetiologies. J Small Anim Pract. 2018;59(10):616-624. https://doi.org/10.1111/jsap.12910
  30. Moisseiev J, Bartov E, Schochat A, Blumenthal M. Long-term study of the prevalence of capsular opacification following extracapsular cataract extraction. J Cataract Refract Surg. 1989;15(5):531-533. https://doi.org/10.1016/S0886-3350(89)80110-5
  31. Jiang J, Shihan MH, Wang Y, Duncan MK. Lens epithelial cells initiate an inflammatory response following cataract surgery. Invest Ophthalmol Vis Sci. 2018;59(12):4986-4997. https://doi.org/10.1167/iovs.18-25067
  32. Tokko HA, Hussain F, Al-Awadi A, Mei F, Zeiter JH, Kim C, et al. Factors associated with the development of posterior capsule opacification requiring yttrium aluminum garnet capsulotomy. Optom Vis Sci. 2019;96(7):492-499. https://doi.org/10.1097/OPX.0000000000001396
  33. Bras ID, Colitz CM, Saville WJ, Gemensky-Metzler AJ, Wilkie DA. Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery. Vet Ophthalmol. 2006;9(5):317-327. https://doi.org/10.1111/j.1463-5224.2006.00458.x
  34. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, et al. Retinopathy in diabetes. Diabetes Care. 2004;27 Suppl 1:S84-S87. https://doi.org/10.2337/diacare.27.2007.S84
  35. Lannek EB, Miller PE. Development of glaucoma after phacoemulsification for removal of cataracts in dogs: 22 cases (1987-1997). J Am Vet Med Assoc. 2001;218(1):70-76. https://doi.org/10.2460/javma.2001.218.70
  36. Cullen CL, Ihle SL, Webb AA, McCarville C. Keratoconjunctival effects of diabetes mellitus in dogs. Vet Ophthalmol. 2005;8(4):215-224. https://doi.org/10.1111/j.1463-5224.2005.00389.x
  37. Yee RW, Matsuda M, Kern TS, Engerman RL, Edelhauser HF. Corneal endothelial changes in diabetic dogs. Curr Eye Res. 1985;4(7):759-766. https://doi.org/10.3109/02713688509020031