대한방사성의약품학회지 (Journal of Radiopharmaceuticals and Molecular Probes)

  • 제9권2호
  • /
  • Pages.101-105
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  • 2023
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  • 2384-1583(pISSN)
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  • 2508-3848(eISSN)
대한방사성의약품학회 (Korean Society of Radiopharmaceuticals and Molecular Probes)
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Controversies in the Hypoxic Uptake Mechanism of Copper(II) diacetyl-di(N4-methylthiosemicarbazone): An Updated Review

  • Thuy Tien Nguyen (Department of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) ;
  • Huu Bao Nguyen (Department of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) ;
  • Min-Kyoung Kang (Non-Clinical Evaluation Center, KBIO Health) ;
  • Jeongsoo Yoo (Department of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University)
  • 투고 : 2023.12.13
  • 심사 : 2023.12.22
  • 발행 : 2023.12.30
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초록

Cu(II) diacetyl-di(N4-methylthiosemicarbazone), also known as Cu(II)-ATSM, is a popular copper-complexed thiosemicarbazone derivative that has been widely studied for hypoxia. [64Cu]Cu-ATSM has emerged as an effective tracer for positron emission tomography imaging to functionally characterize hypoxic tumors. However, understanding the precise mechanism of cellular uptake and metabolism of Cu(II)-ATSM remains a controversial task in which different hypotheses have been proposed. Herein, we will elucidate the current findings regarding the hypoxic uptake mechanism of Cu(II)-ATSM. Particularly, we will investigate the cell internalization mechanism and intracellular reduction of Cu(II)-ATSM.

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과제정보

This work was supported by the R&D program of the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (No. RS-2023-00207942, and RS-2022-00197770). This research was also partially supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI22C1989).

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