대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제44권5호
  • /
  • Pages.324-328
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  • 2023
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  • 1229-0807(pISSN)
  • /
  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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펄스자기장(PMF)을 이용한 대식세포와 T 세포의 염증활성도 변화추이에 대한 연구

A Study on the Change in Inflammatory Activity of Macrophages and T Cells Using Pulsed Magnetic Field

  • 김소진 (상지대학교 보건과학대학 디지털헬스케어학과) ;
  • 이현숙 (상지대학교 보건과학대학 디지털헬스케어학과)
  • Sojin Kim (Department of Digital Healthcare, Sangji University) ;
  • Hyunsook Lee (Department of Digital Healthcare, Sangji University)
  • 투고 : 2023.08.02
  • 심사 : 2023.10.13
  • 발행 : 2023.10.31
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초록

Excessive inflammation in the body causes immune cells to release cytokines that damage normal tissues and cells, leading to rheumatoid arthritis and sepsis. Pulsed magnetic field(PMF) stimulation has many applications in the treatment of neurological, muscular disorders and pain. Therefore, in this study, we aim to investigate the effect of PMF stimulation on the regulation of excessive inflammation in the overall immune system. Macrophages, a primary immune cell, and T cells, a secondary immune cell, were co-cultured in the insert wells under the same conditions, and then inflammation was artificially induced. The changes in inflammatory activity following PMF stimulation were measured by pH and IL-6 concentration. After inflammation induction, both cells became more acidic and increased IL-6 expression, but after PMF stimulation, we observed improved acidification of macrophages and T cells and decreased IL-6 expression. Our results showed that infected macrophages activated T cells and that the recovery of excessive inflammatory response regulation after PMF stimulation proceeded more rapidly in macrophages. Therefore, this study suggests that PMF has a positive anti-inflammatory effect on the overall immune system and thus has the potential to be used as a non-invasive therapy for the treatment of chronic inflammatory diseases.

키워드

과제정보

이 논문은 교육과학기술부의 재원으로 한국연구재단의 이공분야 기초 연구사업 (NRF-2021R1F1A1060167)의 지원으로 수행한 결과이다.

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