Mycobiology

The Korean Society of Mycology (한국균학회)
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Comparative Analysis of Anticancer and Antibacterial Activities among Seven Trametes Species

  • Ha Thi Kim Nguyen (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Jiwon Lee (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Yejin Park (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Hyon Jin Park (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Soon Kil Ahn (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Jae Kwang Kim (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University) ;
  • Dong-Ku Kang (Department of Chemistry, College of Natural Sciences, Incheon National University) ;
  • Minkyeong Kim (Species Diversity Research Division, National Institute of Biological Resources) ;
  • Chorong Ahn (Species Diversity Research Division, National Institute of Biological Resources) ;
  • Changmu Kim (Species Diversity Research Division, National Institute of Biological Resources) ;
  • Jaehyuk Choi (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
  • Received : 2023.06.14
  • Accepted : 2023.08.08
  • Published : 2023.08.31
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Abstract

Species in the genus Trametes (Basidiomycota, Polyporales) have been used in natural medicine for a long time. Many studies reported that mycelia or fruiting bodies of Trametes spp. exhibited effects of antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, comparative analysis in this genus is scarce due to limitation of morphological identification and the sample number. In this study, the 19 strains of seven Trametes species were chosen to generate a five-gene-based phylogeny with the 31 global references. In addition, 39 culture extracts were prepared for 13 strains to test for anticancer and antibacterial activities. Strong anticancer activities were found in several extracts from T. hirsuta and T. suaveolens. Anticancer activities of T. suaveolens, T. cf. junipericola and T. trogii were first described here. The antibacterial ability of T. versicolor and T. hirsuta extracts has been confirmed. The antibacterial activities of T. suaveolens have been reported at the first time in this study. These results suggest an efficient application of the genus Trametes as the drug resources especially for anticancer agents.

Keywords

Acknowledgement

The authors thank to Dr. Young Won Lim (KMRB) for the support with the Trametes species strains.

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