Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity

  • Yang Xiang (Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University) ;
  • Xiaoshun Zhang (Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University) ;
  • Zhiling Tian (Shanghai Key Laboratory of Forensic Medicine, Ministry of Justice, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Academy of Forensic Science) ;
  • Yibin Cheng (Shanghai Key Laboratory of Forensic Medicine, Ministry of Justice, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Academy of Forensic Science) ;
  • Ningguo Liu (Shanghai Key Laboratory of Forensic Medicine, Ministry of Justice, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Academy of Forensic Science) ;
  • Xiaojing Meng (Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University)
  • Received : 2023.01.16
  • Accepted : 2023.06.07
  • Published : 2023.10.15
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Abstract

The production of industrial solvents and adhesives often utilizes 1,2-dichloroethane (1,2-DCE), a highly toxic halogenated hydrocarbon compound. Occupational 1,2-DCE poisoning occurs frequently and is a public health concern. Exposure to 1,2-DCE can damage the brain, liver, and kidneys. The main and most severe damage caused by exposure to 1,2-DCE is to the nervous system, especially the central nervous system. Current research on 1,2-DCE mainly focuses on the mechanism of brain edema. Several possible mechanisms of 1,2-DCE neurotoxicity have been proposed, including oxidative stress, calcium overload, blood-brain barrier damage, and neurotransmitter changes. This article reviews the research progress on 1,2-DCE neurotoxicity and the mechanism behind it to provide a scientific basis for the prevention and treatment of 1,2-DCE poisoning.

Keywords

Acknowledgement

This work was supported by grants from Central Research Institute Public Project (No. 2021G-4), National Key Research and Development Program of China (No.2022YFC3302002). The funding bodies have not participated in the design of the study and collection, analysis, interpretation of data, or in writing the manuscript. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

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