Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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A Case of Visceral T Cell Lymphoma with Prominent Histiocyte Infiltration in a Dog

  • Myung-Chul Kim (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Du-Min Go (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Sang-Ho Woo (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Jeong-Seop Oh (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Dae-Yong Kim (Laboratory of Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Na-Yon Kim (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Yeseul Yang (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Jae-Ha Jung (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Hwa-Young Youn (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Yongbaek Kim (Laboratory of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University)
  • Received : 2023.08.14
  • Accepted : 2023.09.25
  • Published : 2023.10.31
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Abstract

A 13-year-old intact male English Springer Spaniel presented with anorexia. Physical examination revealed a palpable abdominal mass without peripheral lymphadenopathy. Ultrasonography revealed hepatosplenomegaly and a markedly enlarged hepatic lymph node. Fine-needle aspiration of the splenic and nodal lesions revealed atypical round cells admixed with numerous histiocytes. The dog was euthanized owing to deteriorating condition despite a month of chemotherapy with lomustine. Histopathology revealed obliteration of the normal architecture of the liver, spleen, kidney, and hepatic and mesenteric lymph nodes by CD3+ neoplastic lymphocytes, accompanied by extensive F4/80+ histiocytic infiltration. This report describes a rare presentation of T-cell lymphoma with prominent histiocytic infiltration that may initially be misdiagnosed as histiocytic neoplasia in a dog.

Keywords

Acknowledgement

This study was supported by the Brain Korea 21 Program, Research Institute of Veterinary Sciences, College of Veterinary Medicine, and Seoul National University.

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