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Is conservative treatment (enucleation using modified Carnoy's solution) of odontogenic keratocyst in the maxilla good prognosis?

  • Woo Young Jeon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University) ;
  • Jung Ho Park (Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University) ;
  • Jeong-Kui Ku (Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University) ;
  • Jin-A Baek (Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University) ;
  • Seung-O Ko (Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University)
  • 투고 : 2023.06.05
  • 심사 : 2023.08.02
  • 발행 : 2023.10.31

초록

Odontogenic keratocysts (OKCs) located in the maxillae have rarely been reported in the literature. Standard treatment modalities for OKC range from marsupialization to marginal resection. However, most of the studies on OKC treatment have been related to mandibular OKCs. The anatomical structure and loose bone density of the maxillae and the empty space of the maxillary sinus could allow rapid growth of a lesion and the ability to tolerate tumor occupancy in the entire maxilla within a short period of time. Therefore, OKCs of the maxillae require more aggressive surgery, suchas resection. As an alternative, this report introduces a modified Carnoy's solution, a strong acid, as an adjuvant chemotherapy after cyst enucleation. This report describes the clinical outcomes of enucleation using a modified Carnoy's solution in patients with large OKCs on the posterior maxillae. In three cases, application of a modified Carnoy's solution had few side effects or morbidity. Each patient was followed for four to six years, and none showed any signs of recurrence. In conclusion, adjuvant treatment with a modified Carnoy's solution can be considered a treatment option capable of reducing the recurrence rate of OKC in the maxillae.

키워드

참고문헌

  1. Maurette PE, Jorge J, de Moraes M. Conservative treatment protocol of odontogenic keratocyst: a preliminary study. J Oral Maxillofac Surg 2006;64:379-83. https://doi.org/10.1016/j.joms.2005.11.007 
  2. Myoung H, Hong SP, Hong SD, Lee JI, Lim CY, Choung PH, et al. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:328-33. https://doi.org/10.1067/moe.2001.113109 
  3. Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:5-9; discussion 10. https://doi.org/10.1016/j.tripleo.2005.03.023 
  4. Khan AA, Qahtani SA, Dawasaz AA, Saquib SA, Asif SM, Ishfaq M, et al. Management of an extensive odontogenic keratocyst: a rare case report with 10-year follow-up. Medicine (Baltimore) 2019;98:e17987. https://doi.org/10.1097/md.0000000000017987 
  5. Kaczmarzyk T, Mojsa I, Stypulkowska J. A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities. Int J Oral Maxillofac Surg 2012;41:756-67. https://doi.org/10.1016/j.ijom.2012.02.008 
  6. Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:553-8. https://doi.org/10.1067/moe.2000.110814 
  7. Jo HJ, Kim HY, Kang DC, Leem DH, Baek JA, Ko SO. A clinical study of inferior alveolar nerve damage caused by Carnoy's solution used as a complementary therapeutic agent in a cystic lesion. Maxillofac Plast Reconstr Surg 2020;42:16. https://doi.org/10.1186/s40902-020-00257-4 
  8. Donnelly LA, Simmons TH, Blitstein BJ, Pham MH, Saha PT, Phillips C, et al. Modified Carnoy's compared to Carnoy's solution is equally effective in preventing recurrence of odontogenic keratocysts. J Oral Maxillofac Surg 2021;79:1874-81. https://doi.org/10.1016/j.joms.2021.03.010 
  9. Alchalabi NJ, Merza AM, Issa SA. Using Carnoy's solution in treatment of keratocystic odontogenic tumor. Ann Maxillofac Surg 2017;7:51-6. https://doi.org/10.4103/ams.ams_127_16 
  10. Lal B, Kumar RD, Alagarsamy R, Shanmuga Sundaram D, Bhutia O, Roychoudhury A. Role of Carnoy's solution as treatment adjunct in jaw lesions other than odontogenic keratocyst: a systematic review. Br J Oral Maxillofac Surg 2021;59:729-41. https://doi.org/10.1016/j.bjoms.2020.12.019 
  11. Altas E, Karasen RM, Yilmaz AB, Aktan B, Kocer I, Erman Z. A case of a large dentigerous cyst containing a canine tooth in the maxillary antrum leading to epiphora. J Laryngol Otol 1997;111:641-3. https://doi.org/10.1017/s0022215100138198 
  12. Albright CR, Hennig GH. Large dentigerous cyst of the maxilla near the maxillary sinus: report of case. J Am Dent Assoc 1971;83:1112-5. https://doi.org/10.14219/jada.archive.1971.0414 
  13. Cho JY, Nam KY. Expansile dentigerous cyst invading the entire maxillary sinus: a case report. J Korean Assoc Oral Maxillofac Surg 2012;38:245-8. https://doi.org/10.5125/jkaoms.2012.38.4.245