Genomics & Informatics

  • 제21권3호
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  • Pages.33.1-33.11
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  • 2023
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  • 1598-866X(pISSN)
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  • 2234-0742(eISSN)
한국유전체학회 (Korea Genome Organization)
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Association of CAPN10 gene (rs3842570) polymorphism with the type 2 diabetes mellitus among the population of Noakhali region in Bangladesh: a case-control study

  • Munia Sultana (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Md. Mafizul Islam (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Md. Murad Hossain (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Md. Anisur Rahman (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Shuvo Chandra Das (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Dhirendra Nath Barman (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Farhana Siddiqi Mitu (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University) ;
  • Shipan Das Gupta (Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University)
  • 투고 : 2023.03.30
  • 심사 : 2023.07.02
  • 발행 : 2023.09.30
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초록

Type 2 diabetes mellitus (T2DM) is a multifactorial, polygenic, and metabolically complicated disease. A large number of genes are responsible for the biogenesis of T2DM and calpain10 (CAPN10) is one of them. The association of numerous CAPN10 genetic polymorphisms in the development of T2DM has been widely studied in different populations and noticed inconclusive results. The present study is an attempt to evaluate the plausible association of CAPN10 polymorphism SNP-19 (rs3842570) with T2DM and T2DM-related anthropometric and metabolic traits in the Noakhali region of Bangladesh. This case-control study included 202 T2DM patients and 75 healthy individuals from different places in Noakhali. A significant association (p < 0.05) of SNP-19 with T2DM in co-dominant 2R/3R vs. 3R/3R (odds ratio [OR], 2.7; p=0.0014) and dominant (2R/3R) + (2R/2R) vs. 3R/3R (OR, 2.47; p=0.0011) genetic models was observed. High-risk allele 2R also showed a significant association with T2DM in the allelic model (OR, 1.67; p=0.0109). The genotypic frequency of SNP-19 variants showed consistency with Hardy-Weinberg equilibrium (p > 0.05). Additionally, SNP-19 genetic variants showed potential associations with the anthropometric and metabolic traits of T2DM patients in terms of body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, and triglycerides. Our approach identifies the 2R/3R genotype of SNP-19 as a significant risk factor for biogenesis of T2DM in the Noakhali population. Furthermore, a large-scale study could be instrumental to correlate this finding in overall Bangladeshi population.

키워드

과제정보

This work was supported by the 'Noakhali Science and Technology University- Research Cell' Teachers' grant of the budget year 2021-2022 (Project ID: NSTU/RC-BG-06/T-23/32). We are thankful to the director and all medical staffs of Al-Haj Sirajul Islam Diabetic Hospital in Maijdee, Noakhali for helping us sample and data collection.

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