Journal of Microbiology and Biotechnology

  • 제33권9호
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  • Pages.1250-1256
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  • 2023
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052

  • Dae-Hyun Cho (Cell Factory Research Center, KRIBB) ;
  • Jin-Ho Yun (Cell Factory Research Center, KRIBB) ;
  • Jina Heo (Cell Factory Research Center, KRIBB) ;
  • In-Kyoung Lee (Division of Biotechnology, Jeonbuk National University) ;
  • Yong-Jae Lee (Cell Factory Research Center, KRIBB) ;
  • Seunghee Bae (Korea Institute for Skin and Clinical Sciences, Konkuk University) ;
  • Bong-Sik Yun (Division of Biotechnology, Jeonbuk National University) ;
  • Hee-Sik Kim (Cell Factory Research Center, KRIBB)
  • 투고 : 2023.04.25
  • 심사 : 2023.05.25
  • 발행 : 2023.09.28
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초록

Herein, different extracts of Scenedesmus deserticola JD052, a green microalga, were evaluated in vitro as a potential anti-aging bioagent. Although post-treatment of microalgal culture with either UV irradiation or high light illumination did not lead to a substantial difference in the effectiveness of microalgal extracts as a potential anti-UV agent, the results indicated the presence of a highly potent compound in ethyl acetate extract with more than 20% increase in the cellular viability of normal human dermal fibroblasts (nHDFs) compared with the negative control amended with DMSO. The subsequent fractionation of the ethyl acetate extract led to two bioactive fractions with high anti-UV property; one of the fractions was further separated down to a single compound. While electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy analysis identified this single compound as loliolide, its identification has been rarely reported in microalgae previously, prompting thorough systematic investigations into this novel compound for the nascent microalgal industry.

키워드

과제정보

This work was supported by the Commercializations Promotion Agency for R&D Outcomes (COMPA) grant funded by the MSIT of Korea (No. 2023B100); by the Korea Innovation Foundation (INNOPOLIS) grant funded by the MSIT of Republic of Korea (2022-DD-RD-0067); and by KRIBB (Korea Research Institute of Bioscience and Biotechnology) Research Initiative Program (KGM5252221).

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