Molecules and Cells

  • 제46권10호
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  • Pages.573-578
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  • 2023
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration

  • Chaeryeong Lim (Department of Life Sciences, Pohang University of Science and Technology (POSTECH)) ;
  • Jooyoung Lim (Department of Life Sciences, Pohang University of Science and Technology (POSTECH)) ;
  • Sekyu Choi (Department of Life Sciences, Pohang University of Science and Technology (POSTECH))
  • 투고 : 2023.04.29
  • 심사 : 2023.08.16
  • 발행 : 2023.10.31
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⟨ 이전 논문 다음 논문 ⟩

초록

The mammalian skin contains hair follicles, which are epidermal appendages that undergo periodic cycles and exhibit mini-organ features, such as discrete stem cell compartments and different cellular components. Wound-induced hair follicle neogenesis (WIHN) is the remarkable ability to regenerate hair follicles after large-scale wounding and occurs in several adult mammals. WIHN is comparable to embryonic hair follicle development in its processes. Researchers are beginning to identify the stem cells that, in response to wounding, develop into neogenic hair follicles, as well as to understand the functions of immune cells, mesenchymal cells, and several signaling pathways that are essential for this process. WIHN represents a promising therapeutic approach to the reprogramming of cellular states for promoting hair follicle regeneration and preventing scar formation. In the scope of this review, we investigate the contribution of several cell types and molecular mechanisms to WIHN.

키워드

과제정보

We thank the members of the Choi laboratory for their helpful discussions and comments on the manuscript. This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (NRF-2022R1C1C1011895 and NRF2022M3A9D3016848), Basic Science Research Institute Fund (NRF-2021R1A6A1A10042944), and Korea Basic Science Institute (National Research Facilities and Equipment Center) grant funded by the Ministry of Education (No. 2021R1A6C101A390). This research has been supported by a POSCO Science Fellowship of the POSCO TJ Park Foundation. This work was also supported by a BK21 FOUR Research Fellowship funded by the Ministry of Education, Republic of Korea.

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