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만성 췌장염의 한약 치료에 대한 최근 중의 임상 연구 동향 고찰

A Review of Recent Chinese Clinical Studies on Herbal Medicine Treatments for Chronic Pancreatitis

  • 박채현 (강동경희대학교 한방병원 한방내과) ;
  • 김민정 (강동경희대학교 한방병원 한방내과) ;
  • 박재우 (강동경희대학교 한방병원 한방내과) ;
  • 고석재 (강동경희대학교 한방병원 한방내과)
  • Chae-hyun Park (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Min-jeong Kim (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Jae-woo Park (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Seok-jae Ko (Dept. of Internal Korean Medicine, Kyung Hee University Hospital at Gangdong)
  • 투고 : 2023.07.06
  • 심사 : 2023.09.26
  • 발행 : 2023.09.30

초록

Objectives: This study summarizes current trends and results in clinical studies on herbal medicine treatments for chronic pancreatitis. Methods: Studies published from 2014 to 2023 were searched for on the China National Knowledge Infrastructure (CNKI), PubMed, and KMbase using the keywords "chronic pancreatitis", "herbal medicine", "herb", "만성 췌장염", and "한약". The studies were analyzed according to year, study design, characteristics of the patients, and traditional Chinese medicine (TCM) intervention. Results: In total, 23 studies were selected. There were 21 randomized controlled trials and 2 case-control studies. The most common herbal prescriptions were Qingyi-tang (淸胰湯), Radix Bupleuri (柴胡), Radix Paeoniae Alba (白芍藥), Radix Glycyrrhizae (甘草), Radix Scutellariae (黃芩), and Rhei Rhizoma (大黃). In all the studies, herbal medicine treatments were effective in the treatment of chronic pancreatitis, and efficacy was assessed using clinical symptoms, physicochemical examination, radiological examination, and relapse. Conclusions: Herbal medicine treatment can be an effective treatment for chronic pancreatitis and has potential in clinical practice.

키워드

과제정보

이 성과는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2022R1C1C1004937).

참고문헌

  1. Whitcomb DC, Frulloni L, Garg P, Greer JB, Schneider A, Yadav D, et al. Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition. Pancreatology 2016;16(2):218-24.  https://doi.org/10.1016/j.pan.2016.02.001
  2. Jeon TJ. Management of Pain, Exocrine and Endocrine Insufficiency in Chronic Pancreatitis. Korean J Pancreas Biliary Tract 2020;25(1):5-10.  https://doi.org/10.15279/kpba.2020.25.1.5
  3. Kim HW, Kim J. Etiology and Diagnosis of Chronic Pancreatitis. Korean J Pancreas Biliary Tract 2017;22(2):57-62.  https://doi.org/10.15279/kpba.2017.22.2.57
  4. Park SM. Recent Advances in Management of Chronic Pancreatitis. Korean J Gastroenterol 2015;66(3):144-9.  https://doi.org/10.4166/kjg.2015.66.3.144
  5. Hwang YK, Kim GS, Kim WI. Review of Clinical Research about Herbal Medicine Treatment on Chronic Pancreatitis - Research on CNKI. J Int Korean Med 2017;38(1):48-63.  https://doi.org/10.22246/jikm.2017.38.1.48
  6. 高新建, 杜璞, 赵秋升. 清热行气消胀法治疗肝郁化火型慢性胰腺炎临床研究. 新中医 2022;54(13):55-9. 
  7. 鲁兰波. 自拟中药汤剂在慢性胰腺炎急性发作治疗中的应用效果观察. 中国中医药科技 2020;27(06):950-2. 
  8. 高强, 彭文梅. 中西医结合治疗慢性胰腺炎脾胃湿热证临床观察. 中西医结合心血管病电子杂志 2020;8(17):157-63. 
  9. 段文飞. 柴芍六君子汤合膈下逐瘀汤联合常规疗法治疗慢性胰腺炎术后临床研究. 新中医 2020;52(12):25-8. 
  10. 王丽林. 健脾化湿法治疗急慢性胰腺炎的临床分析. 中医临床研究 2020;12(11):66-8. 
  11. 李雪梅. 胰胆舒颗粒治疗慢性胰腺炎32例的临床观察. 中国社区医师 2020;36(04):116-8. 
  12. 路毅, 张勤生. 柴芩双术汤联合胰酶肠溶胶囊对慢性胰腺炎患者血清sICAM-1, sVCAM-1水平的影响. 世界中西医结合杂志 2019;14(09):1319-23. 
  13. 高西绪, 闫春妮, 赵建民. 中西医结合治疗慢性胰腺炎脾胃湿热证临床观察. 四川中医 2019;37(06):97-9. 
  14. 李春颖, 张永华. 中西医结合治疗慢性胰腺炎疗效分析. 现代医药卫生 2017;33(15):2324-5. 
  15. 杨记康, 邢志芳. 清胰汤加减治疗慢性胰腺炎胰腺囊肿患者31例. 光明中医 2017;32(15):2210-2. 
  16. 王建军, 孙玫. 柴胡疏肝散治疗慢性胰腺炎40例. 光明中医 2017;32(10):1422-4. 
  17. 肖克臣, 邹江. 中西医结合治疗肝胆湿热型慢性胰腺炎32例. 江西中医药 2017;48(01):34-6. 
  18. 赵永祥, 吴向铭, 张建国, 张瑞敏, 刘锵, 姜海山. 中药清胰汤合剂对慢性胰腺炎中炎症因子IL-6的影响. 内蒙古医学杂志 2016;48(04):430-1. 
  19. 王燕平. 柴胡疏肝散联合保和汤加减治疗慢性胰腺炎疗效观察. 中国处方药 2016;14(02):99-100. 
  20. 侯泽军. 中西医结合治疗慢性胰腺炎的疗效观察. 中西医结合心血管病电子杂志 2015;3(18):152-3. 
  21. 肖保增. 中西医结合治疗慢性胰腺炎的疗效观察. 中西医结合心血管病电子杂志 2015;3(17):73-4. 
  22. 张玉洁. 中西医结合治疗慢性胰腺炎40例临床观察. 新中医 2015;47(06):83-5. 
  23. 高丽娟, 郑南, 刘华生. 胰泰复方治疗脾虚型慢性胰腺炎的临床观察. 中医药学报 2015;43(02):122-4. 
  24. 郭洁丽. 清胰汤加胰酶治疗慢性胰腺炎疗效观察. 陕西中医学院学报 2015;38(02):54-5. 
  25. 刘福军. 中西医结合治疗慢性胰腺炎167例临床报告. 中国社区医师 2014;30(36):123-4.  https://doi.org/10.14725/gjicmwm.v2n2a550
  26. 于丹丹, 骆丽媛. 自拟清胰汤治疗慢性胰腺炎40例. 现代养生 2014(18):233. 
  27. 吴德正. 加味血府逐淤汤治疗慢性胰腺炎的临床效果分析. 慢性病学杂志 2014;15(03):218-9. 
  28. 李卓洲, 甘志远. 颈型颈椎病326例小针刀治疗临床观察. 基层医学论坛 2014;18(04):510. 
  29. Ryu JK, Lee JK, Kim YT, Lee DK, Seo DW, Lee KT, et al. Clinical features of chronic pancreatitis in Korea: a multicenter nationwide study. Digestion 2005;72(4):207-11.  https://doi.org/10.1159/000089414
  30. Layer P, Yamamoto H, Kalthoff L, Clain JE, Bakken LJ, DiMagno EP. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology 1994;107(5):1481-7.  https://doi.org/10.1016/0016-5085(94)90553-3
  31. Olesen SS, Juel J, Nielsen AK, Frokjaer JB, Wilder-Smith OHG, Drewes AM. Pain severity reduces life quality in chronic pancreatitis: Implications for design of future outcome trials. Pancreatology 2014;14(6):497-502.  https://doi.org/10.1016/j.pan.2014.09.009
  32. Dominguez-Munoz JE, Phillips M. Nutritional Therapy in Chronic Pancreatitis. Gastroenterol Clin North Am 2018;47(1):95-106.  https://doi.org/10.1016/j.gtc.2017.09.004
  33. Duggan SN, Smyth ND, Murphy A, MacNaughton D, O'Keefe SJD, Conlon KC. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2014;12(2):219-28.  https://doi.org/10.1016/j.cgh.2013.06.016
  34. Ewald N, Kaufmann C, Raspe A, Kloer HU, Bretzel RG, Hardt PD. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes Metab Res Rev 2012;28(4):338-42.  https://doi.org/10.1002/dmrr.2260
  35. Choo JW, Moon SH. Clinical Features, Natural History, and Complications of Chronic Pancreatitis. Korean J Pancreas Biliary Tract 2017;22(2):63-71.  https://doi.org/10.15279/kpba.2017.22.2.63
  36. Braganza JM, Lee SH, McCloy RF, McMahon MJ. Chronic pancreatitis. Lancet 2011;377(9772):1184-97.  https://doi.org/10.1016/S0140-6736(10)61852-1
  37. Lee KH. Medical Management of Chronic Pancreatitis: What Can Physicians Do? Korean J Pancreas Biliary Tract 2017;22(2):72-6.  https://doi.org/10.15279/kpba.2017.22.2.72
  38. Medicine SSI, The National College of Korean Medicine Spleen System International Medicine classroom. Seoul: Koonja; 2009. 
  39. Song CH, Lee SH, Oh SW, Jeong JJ, Kim SY, Lee SM, et al. A Case Report of Chronic Pancreatitis. Korean J Orient Int Med 2007;28(2):391-8. 
  40. Kwak MA, Hwang HJ, Byun JS, Park SD. A Case of Suspicious Chronic Pancreatitis with Abdominal Pain and Coldness. J Int Korean Med 2002;23(3):471-8.