Safety and Health at Work

  • 제14권3호
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  • Pages.279-286
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  • 2023
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  • 2093-7911(pISSN)
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  • 2093-7997(eISSN)
산업안전보건연구원 (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
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Association with Combined Occupational Hazards Exposure and Risk of Metabolic Syndrome: A Workers' Health Examination Cohort 2012-2021

  • Dongmug Kang (Department of Preventive, and Occupational & Environmental Medicine, School of Medicine, Pusan National University) ;
  • Eun-Soo Lee (Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital) ;
  • Tae-Kyoung Kim (Medical Research Institute, Pusan National University) ;
  • Yoon-Ji Kim (Department of Preventive, and Occupational & Environmental Medicine, School of Medicine, Pusan National University) ;
  • Seungho Lee (Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital) ;
  • Woojoo Lee (Department of Public Health Science, Graduate School of Public Health) ;
  • Hyunman Sim (Department of Public Health Science, Graduate School of Public Health) ;
  • Se-Yeong Kim (Department of Preventive, and Occupational & Environmental Medicine, School of Medicine, Pusan National University)
  • 투고 : 2023.04.06
  • 심사 : 2023.08.14
  • 발행 : 2023.09.30
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초록

Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors. Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios. Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio = 1.45: 95% confidence interval = 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects. Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.

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과제정보

The authors thank the department of occupational and Environmental Medicine, Pusan National University Yangsan Hospital for providing raw Y-HEC data. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official opinions of PNUYH.

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