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State of the Art for Refractory Cough: Multidisciplinary Approach

  • Anne E. Vertigan (Department of Speech Pathology, John Hunter Hospital)
  • Received : 2023.03.17
  • Accepted : 2023.07.31
  • Published : 2023.10.31

Abstract

Chronic cough is a common problem that can be refractory to medical treatment. Nonpharmaceutical management of chronic cough has an important role in well selected patients. This review article outlines the history of chronic cough management, current approaches to speech pathology management of the condition and new modalities of nonpharmaceutical treatment. There is a need for further research into nonpharmaceutical options with well described randomised control trials.

Keywords

References

  1. Haque RA, Usmani OS, Barnes PJ. Chronic idiopathic cough: a discrete clinical entity? Chest 2005;127:1710-3.  https://doi.org/10.1378/chest.127.5.1710
  2. Song WJ, Chang YS, Faruqi S, Kim JY, Kang MG, Kim S, et al. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J 2015;45:1479-81.  https://doi.org/10.1183/09031936.00218714
  3. Jin HJ, Kim CW. Understanding the impact of chronic cough on the quality of life in the general population. Allergy Asthma Immunol Res 2020;12:906-9.  https://doi.org/10.4168/aair.2020.12.6.906
  4. Slovarp L, Loomis BK, Glaspey A. Assessing referral and practice patterns of patients with chronic cough referred for behavioral cough suppression therapy. Chron Respir Dis 2018;15:296-305.  https://doi.org/10.1177/1479972318755722
  5. Song WJ, Chang YS, Morice AH. Changing the paradigm for cough: does 'cough hypersensitivity' aid our understanding? Asia Pac Allergy 2014;4:3-13.  https://doi.org/10.5415/apallergy.2014.4.1.3
  6. Irwin RS, Corrao WM, Pratter MR. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis 1981;123:413-7. 
  7. Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990;141:640-7.  https://doi.org/10.1164/ajrccm/141.3.640
  8. Morice AH. The cough hypersensitivity syndrome: a novel paradigm for understanding cough. Lung 2010;188 Suppl 1:S87-90.  https://doi.org/10.1007/s00408-009-9185-z
  9. Vertigan AE, Gibson PG. Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers. J Voice 2011;25:596-601.  https://doi.org/10.1016/j.jvoice.2010.07.009
  10. Ryan NM, Gibson PG. TP93: Cough reflex hypersensitivity and upper airway hyperresponsiveness in vocal cord dysfunction with chronic cough. Respirology 2006;11(Suppl 2):A48. 
  11. Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL. Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement. J Voice 2007;21:361-83.  https://doi.org/10.1016/j.jvoice.2005.12.008
  12. Vertigan AE, Kapela SL, Gibson PG. Chronic cough in vocal cord dysfunction: description of a clinical entity. Respir Med 2020;168:105990. 
  13. Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet 2012;380:1583-9.  https://doi.org/10.1016/S0140-6736(12)60776-4
  14. Vertigan AE, Kapela SL, Ryan NM, Birring SS, McElduff P, Gibson PG. Pregabalin and speech pathology combination therapy for refractory chronic cough: a randomized controlled trial. Chest 2016;149:639-48.  https://doi.org/10.1378/chest.15-1271
  15. Cohen SM, Misono S. Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. Otolaryngol Head Neck Surg 2013;148:374-82.  https://doi.org/10.1177/0194599812471817
  16. McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, et al. Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet 2022;399:909-23.  https://doi.org/10.1016/S0140-6736(21)02348-5
  17. Ando A, Smallwood D, McMahon M, Irving L, Mazzone SB, Farrell MJ. Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control. Thorax 2016;71:323-9.  https://doi.org/10.1136/thoraxjnl-2015-207425
  18. Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL. Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy. Thorax 2006;61:1065-9.  https://doi.org/10.1136/thx.2006.064337
  19. Chamberlain Mitchell SA, Garrod R, Clark L, Douiri A, Parker SM, Ellis J, et al. Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial. Thorax 2017;72:129-36.  https://doi.org/10.1136/thoraxjnl-2016-208843
  20. Slinger C, Mehdi SB, Milan SJ, Dodd S, Matthews J, Vyas A, et al. Speech and language therapy for management of chronic cough. Cochrane Database Syst Rev 2019;7:CD013067. 
  21. Ilicic AM, Oliveira A, Habash R, Kang Y, Kho M, Goldstein R, et al. Non-pharmacological management of non-productive chronic cough in adults: a systematic review. Front Rehabil Sci 2022;3:905257. 
  22. Raj AA, Pavord DI, Birring SS. Clinical cough IV: what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol 2009:311-20. 
  23. Ryan NM, Vertigan AE, Bone S, Gibson PG. Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough. Cough 2010;6:5. 
  24. Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG. A comparison of two approaches to the treatment of chronic cough: perceptual, acoustic, and electroglottographic outcomes. J Voice 2008;22:581-9.  https://doi.org/10.1016/j.jvoice.2007.01.001
  25. Chamberlain Mitchell SA, Ellis J, Ludlow S, Pandyan A, Birring SS. Non-pharmacological interventions for chronic cough: the past, present and future. Pulm Pharmacol Ther 2019;56:29-38.  https://doi.org/10.1016/j.pupt.2019.02.006
  26. Ribeiro VV, Lopes LW, de Medeiros CM, da Silva ACF, de Medeiros Neto AH, Behlau M. Effectiveness of the therapy program for management of chronic cough: preliminary data from a randomized clinical trial. Am J Speech Lang Pathol 2022;31:1611-20.  https://doi.org/10.1044/2022_AJSLP-21-00381
  27. Chamberlain Mitchell SA, Garrod R, Clark L, Douiri A, Parker SM, Ellis J, et al. Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial. Thorax 2017;72:129-36.  https://doi.org/10.1136/thoraxjnl-2016-208843
  28. Shembel AC, Rosen CA, Zullo TG, Gartner-Schmidt JL. Development and validation of the cough severity index: a severity index for chronic cough related to the upper airway. Laryngoscope 2013;123:1931-6.  https://doi.org/10.1002/lary.23916
  29. Vertigan AE, Kapela SM, Kearney EK, Gibson PG. Laryngeal dysfunction in cough hypersensitivity syndrome: a cross-sectional observational study. J Allergy Clin Immunol Pract 2018;6:2087-95.  https://doi.org/10.1016/j.jaip.2018.04.015
  30. Singh N, Driessen AK, McGovern AE, Moe AA, Farrell MJ, Mazzone SB. Peripheral and central mechanisms of cough hypersensitivity. J Thorac Dis 2020;12:5179-93.  https://doi.org/10.21037/jtd-2020-icc-007
  31. Mannini C, Bernacchi G, Bonti V, Cinelli E, Mutolo D, Fontana GA, et al. Somatic points for cough and urge to cough in chronic coughers. Respir Med 2022;200:106929. 
  32. Gui P, Wang L, Guo L, Wu C, Zhang B, Chen C, et al. Effects of transcranial direct current stimulation on cough reflex and urge-to-cough in healthy young adults. Respir Res 2022;23:99. 
  33. Quibin K, Crawley BK, Saab R, Krishna P, Murry T. Expiratory muscle strength treatment for refractory chronic cough: a short-term single exercise program. J Voice 2002 Mar 5 [Epub]. https://doi.org/10.1016/j.jvoice.2022.01.011. 
  34. Slovarp L, Reynolds JE, Bozarth-Dailey E, Popp S, Campbell S, Morkrid P. Cough desensitization treatment: a randomized, sham-controlled pilot trial for patients with refractory chronic cough. Respir Med 2022;193:106739. 
  35. Kang Y, Kupfer RA, Ford-Baldner E, Kluin KJ, Hervey-Jumper SL, Morrison RJ. Management of intractable chronic cough during awake craniotomy: illustrative case. J Neurosurg Case Lessons 2021;2:CASE21480. 
  36. Weinberger M, Lockshin B. When is cough functional, and how should it be treated? Breathe (Sheff) 2017;13:22-30. https://doi.org/10.1183/20734735.015216