DOI QR코드

DOI QR Code

Consequence of Synthetic Bone Substitute Used for Alveolar Cleft Graft Reconstruction (Preliminary Clinical Study)

  • Rawaa Y. Al-Rawee (Department of Oral and Maxillofacial Surgery, Al-Salam Teaching Hospital) ;
  • Bashar Abdul-Ghani Tawfeeq (Department of Oral and Maxillofacial Surgery, Al-Noor University College) ;
  • Ahmed Mothafar Hamodat (Department of Pediatric Surgery, Al-Khansa Teaching Hospital) ;
  • Zaid Salim Tawfek (Paedo Ortho Prevention Department, Alnoor University College)
  • Received : 2022.04.28
  • Accepted : 2023.06.15
  • Published : 2023.09.15

Abstract

Background The outcome of alveolar grafting with synthetic bone substitute (Osteon III) in various bone defect volumes is highlighted. Methods A prospective study was accomplished on 55 patients (6-13 years of age) with unilateral alveolar bone cleft. Osteon III, consisting of hydroxyapatite and tricalcium phosphate, is used to reconstruct the defect. Alveolus defect diameter was calculated before surgery (V1), after 3 months (V2), and finally after 6 months (V3) postsurgery. In the t-test, a significant difference and correlation between V1, V2, and V3 are stated. A p-value of 0.01 is considered a significant difference between parameters. Results The degree of cleft is divided into three categories: small (9 cases), medium (20 patients), and large (26 cases).The bone volume of the clefted site is divided into three steps: volume 1: (mean 18.1091 mm3); step 2: after 3 months, volume 2 resembles the amount of unhealed defect (mean 0.5109 mm3); and the final bone volume assessment is made after 6 months (22.5455 mm3). Both show statistically significant differences in bone volume formation. Conclusion An alloplastic bone substitute can also be used as a graft material because of its unlimited bone retrieval. Osteon III can be used to reconstruct the alveolar cleft smoothly and effectively.

Keywords

Acknowledgement

The authors acknowledgein this article the Ethical Approval Committee and the surgical staff assist in surgeries.

References

  1. Kang NH. Current methods for the treatment of alveolar cleft. Arch Plast Surg 2017;44(03):188-193  https://doi.org/10.5999/aps.2017.44.3.188
  2. Lexer E. Die verwendung der freien knochenplastic nebst versuchen uber gelenkversteifung & gelenk-transplantation. Arth Klin Chir. 1908;86:939 
  3. Schmid E. Die aufbauende kieferkammplastik. Ost J Stomat. 1954;51:582-583 
  4. Eppley BL, van Aalst JA, Robey A, Havlik RJ, Sadove AM. The spectrum of orofacial clefting. Plast Reconstr Surg 2005;115(07):101e-114e  https://doi.org/10.1097/01.PRS.0000164494.45986.91
  5. Kyung H, Kang N. Management of alveolar cleft. Arch Craniofac Surg 2015;16(02):49-52  https://doi.org/10.7181/acfs.2015.16.2.49
  6. Cohen M, Polley JW, Figueroa AA. Secondary (intermediate) alveolar bone grafting. Clin Plast Surg 1993;20(04):691-705  https://doi.org/10.1016/S0094-1298(20)32408-1
  7. Ullah H, Qayyum Z, Jamal M, Asim M, Khan MW. Donor site morbidity after bone harvesting from iliac crest for maxillofacial region. Pak Oral Dent J 2018;38(01):21-25 
  8. Khan MS, Shuang M, Liu XL, Xu S, & Liang HF. Current concept in alveolar cleft management. Bangabandhu Sheikh Mujib Medical University Journal 2017;10(04):195 
  9. Rawashdeh MA, Telfah H. Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity. Br J Oral Maxillofac Surg 2008;46(08):665-670  https://doi.org/10.1016/j.bjoms.2008.07.184
  10. Santiago PE, Schuster LA, Levy-Bercowski D. Management of the alveolar cleft. Clin Plast Surg 2014;41(02):219-232  https://doi.org/10.1016/j.cps.2014.01.001
  11. Dalkyz M, Ozcan A, Yapar M, Gokay N, Yuncu M Evaluation of the effects of different biomaterials on bone defects. Implant Dent 2000;9(03):226-235  https://doi.org/10.1097/00008505-200009030-00008
  12. Lew D, Farrell B, Bardach J, Keller J. Repair of craniofacial defects with hydroxyapatite cement. J Oral Maxillofac Surg 1997;55(12):1441-1449, discussion 1449-1451  https://doi.org/10.1016/S0278-2391(97)90647-9
  13. Shirota T, Kurabayashi H, Ogura H, Seki K, Maki K, Shintani S. Analysis of bone volume using computer simulation system for secondary bone graft in alveolar cleft. Int J Oral Maxillofac Implants 2010;39(09):904-908  https://doi.org/10.1016/j.ijom.2010.04.050
  14. Abyholm FE, Bergland O, Semb G. Secondary bone grafting of alveolar clefts. A surgical/orthodontic treatment enabling a non-prosthodontic rehabilitation in cleft lip and palate patients. Scand J Plast Reconstr Surg 1981;15(02):127-140  https://doi.org/10.3109/02844318109103425
  15. Mahardawi B, Boonsiriseth K, Pairuchvej V, Wongsirichat N. Alveolar cleft bone grafting: factors affecting case prognosis. J Korean Assoc Oral Maxillofac Surg 2020;46(06):409-416  https://doi.org/10.5125/jkaoms.2020.46.6.409
  16. Yasar D. Bone Grafting - Recent Advances with Special References to Cranio-Maxillofacial Surgery. December 19, 2018. ISBN: 978-1-78984-883-0. PRINT ISBN: 978-1-78984-882-3 EBOOK ISBN: 978-1-83881-763-3 
  17. Sakkas A, Wilde F, Heufelder M, Winter K, Schramm A. Autogenous bone grafts in oral implantology-is it still a "gold standard"? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent 2017;3(01):23 
  18. Almaiman M, Al-Bargi HH, Manson P. Complication of anterior iliac bone graft harvesting in 372 adult patients from may 2006 to may 2011 and a literature review. Craniomaxillofac Trauma Reconstr 2013;6(04):257-266  https://doi.org/10.1055/s-0033-1357510
  19. de Rezende Barbosa GL, Wood JS, Pimenta LA, Maria de Almeida S, Tyndall DA. Comparison of different methods to assess alveolar cleft defects in cone beam CT images. Dentomaxillofac Radiol 2016;45(02):20150332 
  20. Elhaddaoui R, Bahije L, Zaoui F, Rerhrhaye W. Timing of alveolar bone graft and sequences of canine eruption in cases of cleft lip and palate: a systematic review [in French]. Orthod Fr 2017;88(02):193-198  https://doi.org/10.1051/orthodfr/2017011
  21. Du F, Wu H, Li H, et al. Bone marrow mononuclear cells combined with beta-tricalcium phosphate granules for alveolar cleft repair: a 12-month clinical study. Sci Rep 2017;7(01):13773 
  22. Shavit E, Shavit I, Pinchasov D, Shavit D, Pinchasov G, Juodzbalys G. The use of tooth derived bone graft materials in sinus augmentation procedures: a systematic review. J Oral Maxillofac Res 2019;10(02):e1-e1  https://doi.org/10.5037/jomr.2019.10201
  23. Goudy S, Lott D, Burton R, Wheeler J, Canady J. Secondary alveolar bone grafting: outcomes, revisions, and new applications. Cleft Palate Craniofac J 2009;46(06):610-612  https://doi.org/10.1597/08-126.1
  24. Cho-Lee G-Y, Garcia-Diez E-M, Nunes R-A, Marti-Pages C, SieiraGil R, Rivera-Baro A Review of secondary alveolar cleft repair. Ann Maxillofac Surg 2013;3(01):46-50  https://doi.org/10.4103/2231-0746.110083
  25. Jamjoom A, Cohen RE. Grafts for ridge preservation. J Funct Biomater 2015;6(03):833-848  https://doi.org/10.3390/jfb6030833
  26. Sheikh Z, Sima C, Glogauer M. Bone replasubstitute materials and techniques used for achieving vertical alveolar bone augmentation. Materials (Basel) 2015;8(06):2953-2993  https://doi.org/10.3390/ma8062953
  27. Han-Seung K, Sangwoon L, Jae J. Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity. Nanomaterials 2021;11:213. Accessed July 15, 2023 at: https://doi.org/10.3390/nano11010213 
  28. Wang M, Cheng X, Zhu W, Holmes B, Keidar M, Zhang LG. Design of biomimetic and bioactive cold plasma-modified nanostructured scaffolds for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Tissue Eng Part A 2014;20(5-6):1060-1071  https://doi.org/10.1089/ten.tea.2013.0235
  29. Perez RA, Ginebra MP. Injectable collagen/α-tricalcium phosphate cement: collagen-mineral phase interactions and cell response. J Mater Sci Mater Med 2013;24(02):381-393  https://doi.org/10.1007/s10856-012-4799-8
  30. Akkouch A, Zhang Z, Rouabhia M. Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold. J Biomater Appl 2014;28(06):922-936  https://doi.org/10.1177/0885328213486705
  31. Battafarano G., Rossi M, De Martino V, Marampon F, Borro L, Secinaro A, Del Fattore A. Strategies for Bone Regeneration: From Graft to Tissue Engineering. Int. J. Mol. Sci 2021;22:1128 
  32. Melilli G, Carmagnola I, Tonda-Turo C, Pirri F, Ciardelli G, Sangermano M, Hakkarainen M, Chiappone A. DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels. Polymers 2020;12(08):1655 
  33. Devi Y, Nagendra H, Shenoy S, Chatterjee K, Venkatesan J. Fucoidan-incorporated composite scaffold stimulates osteogenic differentiation of mesenchymal stem cells for bone tissue engineering. Drugs 2022;20:589 
  34. Velasquez P, Luklinska ZB, Meseguer-Olmo L, et al. αTCP ceramic doped with dicalcium silicate for bone regeneration applications prepared by powder metallurgy method: in vitro and in vivo studies. J Biomed Mater Res A 2013;101(07):1943-1954  https://doi.org/10.1002/jbm.a.34495
  35. Honma K, Kobayashi T, Nakajima T, Hayasi T. Computed tomographic evaluation of bone formation after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg 1999;57(10):1209-1213  https://doi.org/10.1016/S0278-2391(99)90488-3
  36. Trindade IK, Mazzottini R, Silva Filho OG, Trindade IEK, Deboni MCZ. Long-term radiographic assessment of secondary alveolar bone grafting outcomes in patients with alveolar clefts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100(03):271-277  https://doi.org/10.1016/j.tripleo.2005.03.012
  37. Tan AE, Brogan WF, McComb HK, Henry PJ. Secondary alveolar bone grafting-five-year periodontal and radiographic evaluation in 100 consecutive cases. Cleft Palate Craniofac J 1996;33(06):513-518
  38. Enemark H, Sindet-Pedersen S, Bundgaard M. Long-term results after secondary bone grafting of alveolar clefts. J Oral Maxillofac Surg 1987;45(11):913-919  https://doi.org/10.1016/0278-2391(87)90439-3
  39. Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 2014;9(01):18 
  40. Sohn HS, Oh JK. Review of bone graft and bone substitutes with an emphasis on fracture surgeries. Biomater Res 2019;23:9 
  41. Elsalanty ME, Genecov DG. Bone grafts in craniofacial surgery. Craniomaxillofac Trauma Reconstr 2009;2(03):125-134  https://doi.org/10.1055/s-0029-1215875
  42. Buser Z, Brodke DS, Youssef JA, et al. Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review. J Neurosurg Spine 2016;25(04):509-516  https://doi.org/10.3171/2016.1.SPINE151005
  43. Valtanen RS, Yang YP, Gurtner GC, Maloney WJ, Lowenberg DW. Synthetic and bone tissue engineering graft substitutes: what is the future? Injury 2021;52(Suppl 2):S72-S77  https://doi.org/10.1016/j.injury.2020.07.040
  44. Betz RR. Limitations of autograft and allograft: new synthetic solutions. Orthopedics 2002;25(05):s561-s570  https://doi.org/10.3928/0147-7447-20020502-04